{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T20:27:11Z","timestamp":1793737631723,"version":"4.6.1"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Chronic atrophic gastritis (CAG) is considered to be closely related to <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) infection and characterized by the atrophy and\/or intestinal metaplasia (IM) of the gastric mucosa in pathology. CAG is often regarded as the precancerous lesion of gastric cancer and <jats:italic>H. pylori<\/jats:italic> infection stimulates the development of atrophy and IM and the progression of gastric cancer through the persistent effect acting on the gastric mucosa, including releasing inflammatory factors such as Interleukin-8(IL-8). From the molecular biology perspective, growing evidence shows that <jats:italic>H. pylori<\/jats:italic> probably induce the expression of NF-\u03baB, miR-204, miR-27a, hnRNPA2B1, and JARID1B, which play crucial roles in the progression of CAG into gastric cancer. In addition, <jats:italic>H. pylori<\/jats:italic> can increase Epstein-Barr virus (EBV) infection, and the co-infection will jointly increase gastric cancer risk. Furthermore, <jats:italic>H. pylori<\/jats:italic> induces cellular senescence and promotes atrophy progression and finally increases the gastric cancer risk. This review aims to explore the carcinogenic mechanisms of <jats:italic>H. pylori<\/jats:italic> related CAG in order to provide theoretical foundations for the pathogenesis mechanism and early detection and prevention of gastric cancer.<\/jats:p>","DOI":"10.3389\/fmed.2025.1504749","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T06:37:32Z","timestamp":1740033452000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Association of Helicobacter pylori related chronic atrophic gastritis and gastric cancer risk: a literature 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