{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T19:56:12Z","timestamp":1772567772948,"version":"3.50.1"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Primary cardiac synovial sarcoma (PCSS) most commonly originates in the right atrium of the heart and is exceptionally rare. Although biomarkers of autoimmune diseases, such as antinuclear antibodies (ANAs), have been reported as potential indicators of certain tumors, the association between PCSS and ANAs remains unclear. Herein, we describe a case of pleural effusion that was initially considered to be due to connective tissue disease (CTD) but was finally diagnosed as PCSS through endobronchial ultrasound-guided transbronchial mediastinum biopsy (EBUS-TBMB). Clinicians need to update their knowledge regarding the potential association between PCSS and ANAs. This case report also emphasizes the importance of EBUS-TBMB, under the guidance of positron emission tomography\/computed tomography (PET\/CT), in the diagnosis of this rare tumor in an unusual location.<\/jats:p>","DOI":"10.3389\/fmed.2025.1515233","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T07:38:00Z","timestamp":1738741080000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case report: Primary cardiac synovial sarcoma with suspected connective tissue disease diagnosed by EBUS-TBMB"],"prefix":"10.3389","volume":"12","author":[{"given":"Yanmei","family":"Feng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Chi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2202","DOI":"10.1016\/j.athoracsur.2013.01.030","article-title":"Primary cardiac synovial sarcoma","volume":"95","author":"Wang","year":"2013","journal-title":"Ann Thorac Surg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.21873\/invivo.11633","article-title":"Pericardial synovial sarcoma: case report, literature review and pooled analysis","volume":"33","author":"Duran-Moreno","year":"2019","journal-title":"In Vivo"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"7192347","DOI":"10.1155\/2020\/7192347","article-title":"Diagnostic value of TLE1 in synovial sarcoma: a systematic review and Meta-analysis","volume":"2020","author":"El Beaino","year":"2020","journal-title":"Sarcoma"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.3390\/curroncol28030177","article-title":"Synovial sarcoma: a clinical review","volume":"28","author":"Gazendam","year":"2021","journal-title":"Curr Oncol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3389\/fmed.2020.00165","article-title":"Antinuclear antibodies with a homogeneous and speckled immunofluorescence pattern are associated with lack of Cancer while those with a nucleolar pattern with the presence of Cancer","volume":"7","author":"Gauderon","year":"2020","journal-title":"Front Med (Lausanne)"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"320","DOI":"10.3390\/diagnostics14030320","article-title":"Comprehensive exploration of antinuclear antibodies (ANAs): unveiling clinical significance, associations with Cancer, and the nuances of differential diagnosis in positive ANA patients","volume":"14","author":"Kraev","year":"2024","journal-title":"Diagnostics (Basel)"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"A2840","DOI":"10.1164\/ajrccm-conference.2022.205.1_MeetingAbstracts.A2840","article-title":"Cardiac arrest after Valsalva from an occlusive primary cardiac synovial sarcoma in the right atrium","volume-title":"B42. 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(Basel)."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"7407","DOI":"10.3390\/app11167407","article-title":"Synovial sarcoma of the extremities: a literature review","volume":"11","author":"Faur","year":"2021","journal-title":"Appl Sci"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"03000605211037839","DOI":"10.1177\/03000605211037839","article-title":"A rare case of synovial sarcoma with lung, heart and adrenal gland metastasis: a caution for patients and clinicians","volume":"49","author":"Jiang","year":"2021","journal-title":"J Int Med Res"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.critrevonc.2018.05.002","article-title":"Antinuclear antibodies and cancer: a literature review","volume":"127","author":"Vlagea","year":"2018","journal-title":"Crit Rev Oncol Hematol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"36","DOI":"10.4103\/jpo.jpo_11_22","article-title":"Detection of antinuclear antibodies in 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