{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:19:16Z","timestamp":1782958756278,"version":"3.54.5"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This study aims to analyzing scientific publications related to necrotizing pancreatitis and its mortality, identifying key areas and trends, and determining the leading research institutions, authors, countries, and journals actively working in this field.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Web of Science and Scopus databases were searched for articles on NP published between January 1, 2013, and April 22, 2024. Articles published before 2013, conference abstracts, and case reports were excluded. The articles were assessed based on various metrics, including the number of citations, publication dates, countries of origin, institutions, journals, and authors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 929 articles were identified, of which 251 were deemed suitable for analysis after duplicates were removed. China contributed the most articles, followed by the United States and India. The most frequent publications appeared in specialized journals such as \u201cPancreatology\u201d and \u201cJournal of Gastrointestinal Surgery.\u201d The primary research institutions were universities and medical centers. The highest-impact articles focused on minimally invasive treatment methods for NP. There has been a growing body of research in NP over the past decade, particularly in China and the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite advancements in medical science, the mortality rate associated with pancreatic necrosis remains high. This highlights the continued challenge in effectively addressing complications of acute pancreatitis. Researchers worldwide are actively exploring alternative therapeutic approaches to mitigate these complications and improve patient outcomes.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1515418","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T16:09:07Z","timestamp":1737562147000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Global research trends in necrotizing pancreatitis: a bibliometric analysis from 2013 to 2024"],"prefix":"10.3389","volume":"12","author":[{"given":"Gulnur G.","family":"Gainollina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat K.","family":"Jakanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bazylbek S.","family":"Zhakiev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uteugaly G.","family":"Karsakbayev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kairat R.","family":"Taishibayev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bulat A.","family":"Kurmanbayev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/s41575-019-0158-2","article-title":"New insights into acute pancreatitis","volume":"16","author":"Lee","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1053\/j.gastro.2021.09.043","article-title":"Global incidence of acute pancreatitis is increasing over time: a systematic review and Meta-analysis","volume":"162","author":"Iannuzzi","year":"2022","journal-title":"Gastroenterology"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.hpb.2018.08.003","article-title":"A systematic review and meta-analysis of the aetiology of acute pancreatitis","volume":"21","author":"Zilio","year":"2019","journal-title":"HPB"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"16106","DOI":"10.3748\/wjg.v20.i43.16106","article-title":"Surgical management of necrotizing pancreatitis: an overview","volume":"20","author":"Kokosis","year":"2014","journal-title":"World J Gastroenterol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/s0140-6736(14)60649-8","article-title":"Acute pancreatitis","volume":"386","author":"Lankisch","year":"2015","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"24","DOI":"10.5152\/turkjsurg.2017.3820","article-title":"Management of iatrogenic injuries due to endoscopic sphincterotomy: surgical or conservative approaches","volume":"34","author":"Bostanc\u0131","year":"2018","journal-title":"Turk J Surg"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1053\/j.gastro.2018.12.041","article-title":"Organ failure due to systemic injury in acute pancreatitis","volume":"156","author":"Garg","year":"2019","journal-title":"Gastroenterology"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e000248","DOI":"10.1136\/bmjgast-2018-000248","article-title":"Moderately severe and severe acute pancreatitis: a systematic review of the outcomes in the USA and European Union-5","volume":"6","author":"Sarri","year":"2019","journal-title":"BMJ Open Gastroenterol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1159\/000506830","article-title":"Management of Severe Acute Pancreatitis: an update","volume":"102","author":"Gliem","year":"2021","journal-title":"Digestion"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"198","DOI":"10.4240\/wjgs.v11.i4.198","article-title":"Pancreatic necrosis: complications and changing trend of treatment","volume":"11","author":"Rashid","year":"2019","journal-title":"World J Gastrointest Surg"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.cmi.2019.06.017","article-title":"Management of infected pancreatic necrosis in the intensive care unit: a narrative review","volume":"26","author":"Wolbrink","year":"2020","journal-title":"Clin Microbiol Infect"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"S163","DOI":"10.1016\/j.ijsu.2015.12.038","article-title":"Necrotizing pancreatitis: a review of the interventions","volume":"28","author":"Bugiantella","year":"2016","journal-title":"Int J Surg"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1097\/01.sla.0000250414.09255.84","article-title":"Early antibiotic treatment for severe acute necrotizing pancreatitis: a randomized, double-blind, placebo-controlled study","volume":"245","author":"Dellinger","year":"2007","journal-title":"Ann Surg"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"723605","DOI":"10.3389\/fsurg.2021.723605","article-title":"Comparison of different surgical methods for necrotizing pancreatitis: a Meta-analysis","volume":"8","author":"Xiao","year":"2021","journal-title":"Front Surg"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s12876-023-02651-4","article-title":"Clinical characteristics and risk factors of organ failure and death in necrotizing pancreatitis","volume":"23","author":"Yu","year":"2023","journal-title":"BMC Gastroenterol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1097\/mpa.0000000000000200","article-title":"Nationwide epidemiological survey of acute pancreatitis in Japan","volume":"43","author":"Hamada","year":"2014","journal-title":"Pancreas"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.diii.2013.12.018","article-title":"Imaging of acute pancreatitis and its complications. Part 2: complications of acute pancreatitis. Diagnostic and interventional","volume":"96","author":"T\u00fcrkvatan","year":"2015","journal-title":"Imaging"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"13879","DOI":"10.3748\/wjg.v20.i38.13879","article-title":"Treatment of severe acute pancreatitis and its complications","volume":"20","author":"Zerem","year":"2014","journal-title":"World J Gastroenterol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1097\/MPA.0b013e318269c660","article-title":"Interventions for necrotizing pancreatitis summary of a multidisciplinary consensus conference","volume":"41","author":"Freeman","year":"2012","journal-title":"Pancreas"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"184","DOI":"10.5152\/tjg.2018.17542","article-title":"Role of percutaneous catheter drainage as primary treatment of necrotizing pancreatitis","volume":"30","author":"Mehta","year":"2019","journal-title":"Turk J Gastroenterol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1002\/bjs.7304","article-title":"Systematic review of percutaneous catheter drainage as primary treatment for necrotizing pancreatitis","volume":"98","author":"van Baal","year":"2011","journal-title":"Br J Surg"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1089\/lap.2011.0248","article-title":"Short-term outcomes from a multicenter retrospective study in China comparing laparoscopic and open surgery for the treatment of infected pancreatic necrosis","volume":"22","author":"Tan","year":"2012","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"126","DOI":"10.4103\/0972-9941.134875","article-title":"Laparoscopic necrosectomy in acute necrotizing pancreatitis: our experience","volume":"10","author":"Mathew","year":"2014","journal-title":"J Minim Access Surg"},{"key":"ref24","first-page":"115","article-title":"Infected necrotizing pancreatitis. Video-assisted retroperitoneal debridement","volume":"81","author":"Revoredo Rego","year":"2021","journal-title":"Medicina (B Aires)"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1001\/jama.2012.276","article-title":"Endoscopic transgastric vs surgical necrosectomy for infected necrotizing pancreatitis: a randomized trial","volume":"307","author":"Bakker","year":"2012","journal-title":"JAMA"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"980415","DOI":"10.3389\/fonc.2022.980415","article-title":"The global research status and trends of the application of endoscopic ultrasonography in pancreatic tumors over the last decades: a bibliometric study","volume":"12","author":"Xia","year":"2022","journal-title":"Front Oncol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"810774","DOI":"10.3389\/fonc.2022.810774","article-title":"Emerging trends and research foci in tumor microenvironment of pancreatic cancer: a bibliometric and visualized study","volume":"12","author":"Wu","year":"2022","journal-title":"Front Oncol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/JP9.0000000000000015","article-title":"A bibliometric study on pancreatic cystic disease research","volume":"2","author":"Cui","year":"2019","journal-title":"J Pancreatol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.pan.2022.01.009","article-title":"Twenty-year span of global acute pancreatitis trends: a bibliometric analysis","volume":"22","author":"Luo","year":"2022","journal-title":"Pancreatology"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"e23208","DOI":"10.1097\/md.0000000000023208","article-title":"Bibliometric analysis of acute pancreatitis in web of science database based on CiteSpace software","volume":"99","author":"Sun","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0140-6736(17)32404-2","article-title":"Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial","volume":"391","author":"van Brunschot","year":"2018","journal-title":"Lancet"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1053\/j.gastro.2019.07.064","article-title":"American Gastroenterological Association clinical practice update: management of pancreatic necrosis","volume":"158","author":"Baron","year":"2020","journal-title":"Gastroenterology"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1097\/SLA.0000000000000264","article-title":"The role of organ failure and infection in necrotizing pancreatitis: a prospective study","volume":"259","author":"Guo","year":"2014","journal-title":"Ann Surg"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1053\/j.gastro.2018.11.031","article-title":"An endoscopic transluminal approach, compared with minimally invasive surgery, reduces complications and costs for patients with necrotizing pancreatitis","volume":"156","author":"Bang","year":"2019","journal-title":"Gastroenterology"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/jrsm.1530","article-title":"Bibliometric study of 'overviews of systematic reviews' of health interventions: evaluation of prevalence, citation and journal impact factor","volume":"13","author":"Lunny","year":"2022","journal-title":"Res Synth Methods"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1001\/jama.290.12.1624","article-title":"Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy","volume":"290","author":"Tunis","year":"2003","journal-title":"JAMA"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"943932","DOI":"10.3389\/frma.2022.943932","article-title":"Choices of immediate open access and the relationship to journal ranking and publish-and-read deals","volume":"7","author":"Wenaas","year":"2022","journal-title":"Front Res Metr Anal"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/ueg2.12353","article-title":"Prediction of infected pancreatic necrosis in acute necrotizing pancreatitis by the modified pancreatitis activity scoring system","volume":"11","author":"Mao","year":"2023","journal-title":"United European Gastroenterol J"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1007\/s00134-022-06745-7","article-title":"Immune enhancement in patients with predicted severe acute necrotising pancreatitis: a multicentre double-blind randomised controlled trial","volume":"48","author":"Ke","year":"2022","journal-title":"Intensive Care Med"},{"key":"ref40","volume-title":"Bid farewell to the old year and usher in the new","year":"2024"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"104039","DOI":"10.1109\/ACCESS.2020.2999501","article-title":"Coupling coordination degree of government support, financial support and innovation and its impact on economic development","volume":"8","author":"Liu","year":"2020","journal-title":"IEEE Access"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/S0140-6736(20)31310-6","article-title":"Acute pancreatitis","volume":"396","author":"Boxhoorn","year":"2020","journal-title":"Lancet"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1056\/NEJMoa2100826","article-title":"Immediate versus postponed intervention for infected necrotizing pancreatitis","volume":"385","author":"Boxhoorn","year":"2021","journal-title":"N Engl J Med"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"89","DOI":"10.21037\/hbsn-23-132","article-title":"International consensus guidelines on robotic pancreatic surgery in 2023","volume":"13","author":"Liu","year":"2024","journal-title":"Hepatobiliary Surg Nutr"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1038\/s41395-018-0232-3","article-title":"Early (<4 Weeks) Versus Standard (\u22654 Weeks) Endoscopically Centered Step-Up Interventions for Necrotizing Pancreatitis","volume":"113","author":"Trikudanathan","year":"2018","journal-title":"Am J Gastroenterol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1053\/j.gastro.2019.01.269","article-title":"Current Concepts in Severe Acute and Necrotizing Pancreatitis: An Evidence-Based Approach","volume":"156","author":"Trikudanathan","year":"2019","journal-title":"Gastroenterology."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1515418\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T16:09:10Z","timestamp":1737562150000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1515418\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,22]]},"references-count":46,"alternative-id":["10.3389\/fmed.2025.1515418"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1515418","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,22]]},"article-number":"1515418"}}