{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T01:26:01Z","timestamp":1784251561535,"version":"3.55.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Traditional Chinese medicine has great advantages in improving symptoms of CHF such as chest tightness, shortness of breath, and fatigue. In addition, some traditional Chinese medicines can be used as both medicine and food, which have good effects on the prevention and treatment of CHF patients at home.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A comprehensive search across China National Knowledge Infrastructure (CNKI), Wanfang, and Wei Pu (VIP) databases was conducted to retrieve pre-2022 literature related to CHF. After standardization, frequency analysis and Apriori algorithm were used to analyze these data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Among 626 effective medical records, Fuling, Huangqi, and Danshen are the most commonly used herbs; The medication for chest tightness is closely related to Tinglizi; The medication for palpitations is closely related to Guizhi, Fuzi, Zhigancao, and Wuweizi; The medication of fatigue and poor appetite is closely related to Huangqi and Baizhu; The medication for lower limb edema is closely related to Fuling and Tinglizi; The medication for coughing is closely related to the use of Tinglizi, Wuweizi, Kuxingren, and Sangbaipi; Insomnia is closely related to Suanzaoren and Dazao.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The components in traditional Chinese medicine that have anti heart failure effects and reliable evidence can be potential candidates for drug discovery, while dietary therapeutic herbs such as Fuling, Huangqi, Danshen, and Zhigancao can be developed as health products.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1522163","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T15:12:09Z","timestamp":1744125129000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploring natural therapy for chronic heart failure: experience in traditional Chinese medicine treatment before 2022"],"prefix":"10.3389","volume":"12","author":[{"given":"Li-Ping","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanxin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-Xue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Qi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui Hui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/nrcardio.2016.25","article-title":"Epidemiology and aetiology of heart failure","volume":"13","author":"Ziaeian","year":"2016","journal-title":"Nat Rev Cardiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"Mcdonagh","year":"2021","journal-title":"Eur Heart J"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 19902019: a systematic analysis for the global burden of disease study 2019","volume":"396","year":"2020","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e254","DOI":"10.1161\/CIR.0000000000000950","article-title":"Heart disease and stroke statistics-2021 update: a report from the American Heart Association","volume":"143","author":"Virani","year":"2021","journal-title":"Circulation"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart disease and stroke statistics-2020 update: a report from the American Heart Association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"760","DOI":"10.3760\/cma.j.issn.0253-3758.2018.10.004","article-title":"Chinese guidelines for diagnosis and treatment of heart failure 2018","volume":"46","year":"2018","journal-title":"Chinese J Cardiovasc Dis"},{"key":"ref7","first-page":"38","volume-title":"Diabetes","author":"Zhimin","year":"2021"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart disease and stroke statistics-2019 update: a report from the American Heart Association","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circulation"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21654","article-title":"Cancer statistics, 2021","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"449","DOI":"10.13288\/j.11-2166\/r","article-title":"Advantages, disadvantages, and trends of integrated traditional Chinese and Western medicine in the treatment of heart failure","volume":"55","author":"Peiying","year":"2014","journal-title":"J Tradit Chin Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/j.jacc.2013.05.035","article-title":"A multicenter, randomized, double-blind, parallel-group, placebo-controlled study of the effects of qili qiangxin capsules in patients with chronic heart failure","volume":"62","author":"Li","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"85","DOI":"10.13729\/j.issn.1671-7813","article-title":"Meta analysis of the effectiveness and safety of traditional Chinese medicine in improving hemodynamics in chronic heart failure [J]","author":"Bin","year":"2024","journal-title":"J. Pract. Chin. Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"182","DOI":"10.19540\/j.cnki.cjcmm.20161222.040","article-title":"Analysis of on medication rules for Qi-deficiency and blood-stasis syndrome of chronic heart failure based on data mining technology","volume":"42","author":"Wang","year":"2017","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1007\/s11655-022-2892-5","article-title":"A data mining-based study on medication rules of Chinese herbs to treat heart failure with preserved ejection fraction","volume":"28","author":"Guo","year":"2022","journal-title":"Chin J Integr Med"},{"key":"ref15","volume-title":"A retrospective case series study on professor Guo Weiqin's experience in treating chronic heart failure","author":"Qianqian","year":"2021"},{"key":"ref16","first-page":"54","volume-title":"Research on the medication pattern of traditional Chinese medicine in the treatment of chronic heart failure based on data mining [J]","author":"Chen","year":"2023"},{"key":"ref17","first-page":"20","volume-title":"Exploring the prescription rules of traditional Chinese medicine for treating coronary heart disease and heart failure based on data mining [J]Chin. Med. Bull.","author":"Yang","year":"2023"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"718","DOI":"10.13375\/j.cnki.wcjps.2023.06.023","article-title":"Research progress on the medicinal and edible homology of Huangqi","volume":"38","author":"Xi","year":"2023","journal-title":"West China J Pharm"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"594","DOI":"10.3867\/j.issn.1000-3002.2014.04.24","article-title":"Research progress on the chemical composition and diuretic mechanism of diuretics such as Poria cocos, Poria cocos skin, Poria cocos, and Alisma [J]","volume":"28","author":"Zhao","year":"2014","journal-title":"Chin J Pharmacol Toxicol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.jep.2013.03.027","article-title":"Mycology, cultivation, traditional uses, phytochemistry and pharmacology of Wolfi poria cocos (Schwein.) Ryvarden et Gilb: a review","volume":"147","author":"Wang","year":"2013","journal-title":"J Ethnopharmacol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1080\/10286020802133597","article-title":"Poriacosones A and B: two new lanostane triterpenoids from Poria cocos","volume":"10","author":"Zheng","year":"2008","journal-title":"J Asian Nat Prod Res"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e18331","DOI":"10.1111\/jcmm.18331","article-title":"Mechanism of Astragalus membranaceus (Huangqi, HQ) for treatment of heart failure based on network pharmacology and molecular docking","volume":"28","author":"Chen","year":"2024","journal-title":"J Cell Mol Med"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"94","DOI":"10.19664\/j.cnki.1002-2392.210147","article-title":"Research progress on Huangqi and its preparations for the treatment of heart failure [J]","volume":"49","author":"Yu","year":"2021","journal-title":"J. Tradit. Chin. 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