{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:07:35Z","timestamp":1758701255831,"version":"3.44.0"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Urinary bladder paragangliomas (UBPs) are rare tumors of chromaffin tissue originating from the sympathetic innervation of the bladder wall. It constitutes less than 0.05% of bladder tumors and 0.7% of all paragangliomas. The occurrence of UBP during pregnancy is extremely rare. Hypertensive disorders of pregnancy due to paraganglioma significantly increase the risk of adverse maternal and fetal outcomes. Herein, we report the case of UBP in a 28-year-old woman at 34\u202fweeks\u2019 gestation. The baby was successfully delivered, and bladder tumor was excised via partial cystectomy during the same surgical procedure. In addition, we conducted a literature review of paragangliomas during pregnancy, as there are only a few case reports of such diseases and there is no consensus on standard treatment. This study aims to contribute to the enhancement of the diagnosis and treatment of UBP during pregnancy.<\/jats:p>","DOI":"10.3389\/fmed.2025.1527778","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T05:34:10Z","timestamp":1755149650000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Urinary bladder paraganglioma in pregnancy: a case report and literature review"],"prefix":"10.3389","volume":"12","author":[{"given":"Yadong","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongxiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1097\/HJH.0000000000002438","article-title":"Genetics, diagnosis, management and future directions of research of phaeochromocytoma and paraganglioma: a position statement and consensus of the working group on endocrine hypertension of the European Society of Hypertension","volume":"38","author":"Lenders","year":"2020","journal-title":"J Hypertens"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1136\/jmedgenet-2015-103218","article-title":"Recommendations for somatic and germline genetic testing of single pheochromocytoma and paraganglioma based on findings from a series of 329 patients","volume":"52","author":"Curras-Freixes","year":"2015","journal-title":"J Med Genet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"5210","DOI":"10.1210\/jcem.86.11.8034","article-title":"Benign paragangliomas: clinical presentation and treatment outcomes in 236 patients","volume":"86","author":"Erickson","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"457.e9","DOI":"10.1016\/j.urolonc.2017.02.006","article-title":"Genitourinary paraganglioma: demographic, pathologic, and clinical characteristics in the surveillance, epidemiology, and end results database (2000-2012)","volume":"35","author":"Purnell","year":"2017","journal-title":"Urol Oncol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"4479","DOI":"10.2147\/CMAR.S175286","article-title":"Clinicopathological characteristics and survival outcomes of bladder neuroendocrine carcinomas: a population-based study","volume":"10","author":"Niu","year":"2018","journal-title":"Cancer Manag Res"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1007\/PL00013159","article-title":"Adrenal tumors and pregnancy","volume":"23","author":"Harrington","year":"1999","journal-title":"World J Surg"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1111\/1471-0528.16635","article-title":"Pregnancy and phaeochromocytoma\/paraganglioma: clinical clues affecting diagnosis and outcome - 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