{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:06:58Z","timestamp":1756253218894,"version":"3.44.0"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This case report describes a rare instance of human immunodeficiency virus (HIV)-positive, human herpesvirus-8 (HHV-8)-negative, and Epstein-Barr virus (EBV)-negative primary effusion lymphoma (PEL) associated with pulmonary effusions likely caused by congestive heart failure (CHF). The new classification added in the fifth edition of the World Health Organization\u2019s lymphoma classification is named \u201cFluid Overload-Associated Large B-Cell Lymphoma.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The diagnosis and treatment of a 71-years-old male patient with acquired immune deficiency syndrome (AIDS) and PEL admitted to the Department of Infectious Diseases in Chongqing Public Health Medical Center in March 2022 were detailed, and relevant literature was reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patient had been receiving antiretroviral therapy (ART) with lamivudine (3TC) + tenofovir (TDF) + efavirenz (EFV) for 17 years. The primary clinical manifestations were large pericardial and pleural effusions. Pathological examination confirmed HHV-8 and EBV-negative large B-cell lymphoma. The effusions were drained effectively, and the patient received ART and two cycles of R-CDOP chemotherapy. Atrial fibrillation and coronary heart disease (CHD) were diagnosed during the course of the disease. After 2 years of follow-up, no recurrence of symptoms was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case highlights the importance of recognizing rare HHV-8 negative PELs and the need to monitor underlying conditions such as CHD that may contribute to effusion formation. It underscores the diagnostic challenges and the necessity of a multidisciplinary approach in managing such cases.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1527960","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T06:43:57Z","timestamp":1756190637000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["HIV-positive and HHV-8-negative primary effusion lymphoma complicated with coronary heart disease: a Case Report and literature review"],"prefix":"10.3389","volume":"12","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","article-title":"The 5th edition of the world health organization classification of haematolymphoid tumours: lymphoid neoplasms.","volume":"36","author":"Alaggio","year":"2022","journal-title":"Leukemia."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1182\/blood.2020005470","article-title":"KSHV\/HHV8-mediated hematologic diseases.","volume":"139","author":"Cesarman","year":"2022","journal-title":"Blood."},{"key":"B3","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1097\/CCO.0000000000000884","article-title":"HHV-8 associated lymphoma.","volume":"34","author":"Oksenhendler","year":"2022","journal-title":"Curr Opin Oncol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-030-03502-0_1","article-title":"AIDS-associated malignancies.","volume":"177","author":"Vangipuram","year":"2019","journal-title":"Cancer Treat Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2689","DOI":"10.1002\/cncr.30112","article-title":"Human immunodeficiency virus-associated lymphomas in the antiretroviral therapy era: analysis of the national cancer data base.","volume":"122","author":"Olszewski","year":"2016","journal-title":"Cancer."},{"key":"B6","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1051\/medsci\/20183401017","article-title":"Co-infection EBV\/KSHV \u2013 Une alliance efficace [EBV\/KSHV co-infection: an effective partnership].","volume":"34","author":"Gruffat","year":"2018","journal-title":"Med Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1182\/blood-2018-03-791426","article-title":"Biology and management of primary effusion lymphoma.","volume":"132","author":"Shimada","year":"2018","journal-title":"Blood."},{"key":"B8","doi-asserted-by":"publisher","first-page":"343","DOI":"10.3892\/ol.2020.12206","article-title":"Human herpesvirus 8-negative effusion-based lymphoma with indolent clinical behavior in an elderly patient: a case report and literature review.","volume":"20","author":"Kim","year":"2020","journal-title":"Oncol Lett."},{"key":"B9","doi-asserted-by":"publisher","first-page":"4442","DOI":"10.1182\/bloodadvances.2020002293","article-title":"Primary human herpesvirus 8-negative effusion-based lymphoma: a large B-cell lymphoma with favorable prognosis.","volume":"4","author":"Kaji","year":"2020","journal-title":"Blood Adv."},{"key":"B10","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1182\/blood-2003-05-1545","article-title":"Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray.","volume":"103","author":"Hans","year":"2004","journal-title":"Blood."},{"key":"B11","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1111\/his.13428","article-title":"Lymphoproliferative disorders with concurrent HHV8 and EBV infection: beyond primary effusion lymphoma and germinotropic lymphoproliferative disorder.","volume":"72","author":"Wang","year":"2018","journal-title":"Histopathology."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1038\/s41379-022-01091-x","article-title":"Human herpesvirus 8-negative effusion-based large B-cell lymphoma: a distinct entity with unique clinicopathologic characteristics.","volume":"35","author":"Gisriel","year":"2022","journal-title":"Mod Pathol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1111\/ejh.13082","article-title":"Malignant lymphoma in the HIV-positive patient.","volume":"101","author":"Meister","year":"2018","journal-title":"Eur J Haematol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/ajh.24251","article-title":"Classic and extracavitary primary effusion lymphoma in 51 HIV-infected patients from a single institution.","volume":"91","author":"Guillet","year":"2016","journal-title":"Am J Hematol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1002\/cncy.22344","article-title":"Human herpesvirus-8-positive primary effusion lymphoma in HIV-negative patients: single institution case series with a multidisciplinary characterization.","volume":"129","author":"Rossi","year":"2021","journal-title":"Cancer Cytopathol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3143\/geriatrics.58.284","article-title":"[Human herpesvirus 8-unrelated primary effusion lymphoma-like lymphoma that developed during myelodysplastic syndrome].","volume":"58","author":"Aota","year":"2021","journal-title":"Nihon Ronen Igakkai Zasshi."},{"key":"B17","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1093\/qjmed\/hcu232","article-title":"Primary effusion lymphoma in the absence of HIV infection\u2013clinical presentation and management.","volume":"108","author":"Klepfish","year":"2015","journal-title":"QJM."},{"key":"B18","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1002\/dc.23638","article-title":"EBV-associated but HHV8-unrelated double-hit effusion-based lymphoma.","volume":"45","author":"Chen","year":"2017","journal-title":"Diagn Cytopathol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1002\/cncy.21311","article-title":"Kaposi sarcoma herpesvirus\/human herpesvirus-8-negative effusion-based lymphoma: report of 3 cases and review of the literature.","volume":"121","author":"Xiao","year":"2013","journal-title":"Cancer Cytopathol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.11406\/rinketsu.56.1082","article-title":"[Human herpesvirus 8-negative primary effusion lymphoma-like lymphoma with t(8;14)(q24;q32)].","volume":"56","author":"Ogasawara","year":"2015","journal-title":"Rinsho Ketsueki."},{"key":"B21","doi-asserted-by":"publisher","first-page":"e8010","DOI":"10.1097\/MD.0000000000008010","article-title":"Human herpes virus 8-unrelated primary effusion lymphoma-like lymphoma presenting with cardiac tamponade: a case report.","volume":"96","author":"Kim","year":"2017","journal-title":"Medicine."},{"key":"B22","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3960\/jslrt.17020","article-title":"Human herpesvirus 8-unrelated primary effusion lymphoma-like lymphoma following tyrosine kinase inhibitor treatment for chronic myelogenous leukemia.","volume":"57","author":"Kojima","year":"2017","journal-title":"J Clin Exp Hematop."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2647","DOI":"10.1007\/s00277-020-04211-2","article-title":"HHV-8 negative PEL-like lymphoma follicular helper T type in a non-HIV infected elderly.","volume":"100","author":"Kidoguchi","year":"2021","journal-title":"Ann Hematol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"218","DOI":"10.11406\/rinketsu.60.218","article-title":"[Human herpes virus 8-negative primary effusion lymphoma-like lymphoma recurring as a tumor adjacent to theleft atrium].","volume":"60","author":"Horiuchi","year":"2019","journal-title":"Rinsho Ketsueki."},{"key":"B25","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1159\/000350482","article-title":"Self-limited effusion large B-cell lymphoma: two cases of effusion lymphoma maintaining remission after drainage alone.","volume":"130","author":"Nakatsuka","year":"2013","journal-title":"Acta Haematol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"274","DOI":"10.4143\/crt.2016.076","article-title":"Human herpesvirus 8-unrelated primary effusion lymphoma-like lymphoma in an elderly korean patient with a good response to rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone.","volume":"49","author":"Shin","year":"2017","journal-title":"Cancer Res Treat."},{"key":"B27","first-page":"815","article-title":"[Successful treatment with oral low-dose sobuzoxane and etoposide combined with rituximab in an elderly patient with HHV-8-negative primary effusion lymphoma-like lymphoma].","volume":"55","author":"Toyoda","year":"2014","journal-title":"Rinsho Ketsueki."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1527960\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T06:43:59Z","timestamp":1756190639000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1527960\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,26]]},"references-count":27,"alternative-id":["10.3389\/fmed.2025.1527960"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1527960","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,26]]},"article-number":"1527960"}}