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Med."],"abstract":"<jats:p>Traditional Chinese medicine (TCM) has seen a surge in interest in acupuncture as a treatment for polycystic ovary syndrome (PCOS), a condition marked by hyperandrogenism, irregular ovulation, and polycystic ovaries. Acupuncture has been shown to dramatically lower androgen levels in PCOS patients; this effect may be achieved by reducing the secretion of neurotransmitters in the hypothalamic-pituitary-gonadal (HPG) axis and interfering with the hypothalamic-pituitary-adrenal (HPA) axis and its cortisol release. Furthermore, by enhancing glucose metabolism, decreasing inflammation in adipose tissue, and enhancing intercellular communication pathways, acupuncture may indirectly address hyperandrogenemia. Although acupuncture has the potential to treat PCOS, further research is necessary to fully understand its mechanism. It is advised that more clinical research integrating molecular biology and biochemical methods be conducted in the future to determine the precise mechanism of acupuncture's effects on PCOS and to offer new suggestions for managing the condition's symptoms.<\/jats:p>","DOI":"10.3389\/fmed.2025.1531506","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T05:33:50Z","timestamp":1753335230000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Experimental analysis of acupuncture's effects on hyperandrogenemia and related symptoms in PCOS patients"],"prefix":"10.3389","volume":"12","author":[{"given":"Yu-Xiao","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Hua","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue-Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e1071","DOI":"10.1210\/clinem\/dgaa839","article-title":"Update on PCOS: consequences, challenges, and guiding treatment","volume":"106","author":"Hoeger","year":"2021","journal-title":"J Clin Endocrinol Metab."},{"key":"B2","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/S2213-8587(22)00163-2","article-title":"Polycystic ovary syndrome","volume":"10","author":"Joham","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.fertnstert.2018.05.004","article-title":"Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"110","author":"Teede","year":"2018","journal-title":"Fertil Steril."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2206912","DOI":"10.1080\/09513590.2023.2206912","article-title":"Mutational analysis of minichromosome maintenance complex component (MCM) family genes in Chinese Han women with polycystic ovarian syndrome","volume":"39","author":"Zhou","year":"2023","journal-title":"Gynecol Endocrinol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1164186","DOI":"10.3389\/fendo.2023.1164186","article-title":"Gut microbiome and reproductive endocrine diseases: a Mendelian randomization study","volume":"14","author":"Liang","year":"2023","journal-title":"Front Endocrinol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.3390\/antiox12081490","article-title":"The silent threat to women's fertility: uncovering the devastating effects of oxidative stress","volume":"12","author":"Kaltsas","year":"2023","journal-title":"Antioxidants"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1210\/clinem\/dgad463","article-title":"Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome\u2020","volume":"38","author":"Teede","year":"2023","journal-title":"Hum Reprod."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1016\/S0140-6736(85)92552-8","article-title":"Multifollicular ovaries: clinical and endocrine features and response to pulsatile gonadotropin releasing hormone","volume":"326","author":"Adams","year":"1985","journal-title":"Lancet"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1007\/s11011-024-01393-w","article-title":"Stress, hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-gonadal axis, and aggression","volume":"39","author":"Mbiydzenyuy","year":"2024","journal-title":"Metab Brain Dis"},{"key":"B10","doi-asserted-by":"publisher","first-page":"374","DOI":"10.7326\/0003-4819-136-5-200203050-00010","article-title":"Acupuncture: theory, efficacy, and practice","volume":"136","author":"Kaptchuk","year":"2002","journal-title":"Ann Intern Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s40659-023-00441-6","article-title":"Acupuncture regulates the apoptosis of ovarian granulosa cells in polycystic ovarian syndrome-related abnormal follicular development through LncMEG3-mediated inhibition of miR-21-3p","volume":"56","author":"Chen","year":"2023","journal-title":"Biol Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2357737","DOI":"10.1080\/07853890.2024.2357737","article-title":"Dudzi\u0144ska EJ. 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