{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:00:17Z","timestamp":1753891217455,"version":"3.41.2"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Endosalpingiosis, a rare benign condition characterized by ectopic fallopian tube-like epithelium, often coexists with endometriosis. This case report presents a unique instance of florid cystic endosalpingiosis confined to the uterine myometrium\u2014marking the first documented case without associated pelvic pathology. Using multimodal imaging and histopathological analysis, we highlight key diagnostic approaches to distinguish this condition from malignant mimics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 47-year-old woman with a 2-year history of chronic pelvic pain and recent irregular bleeding underwent surgical exploration after imaging revealed isolated, non-communicating cystic lesions within the myometrium. Histopathological examination identified cyst walls lined with ciliated pseudostratified epithelium, confirmed as benign through immunohistochemistry. A 6-year follow-up showed no evidence of recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Florid cystic endosalpingiosis should be considered in the differential diagnosis of cystic uterine lesions. Establishing standardized imaging criteria and adopting fertility-preserving management strategies can help avoid unnecessary radical interventions, optimizing outcomes for premenopausal women.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1537986","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T04:11:00Z","timestamp":1744690260000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Postoperative diagnosis of uterine florid cystic endosalpingiosis: a case report emphasizing diagnostic challenges and multimodal imaging correlation"],"prefix":"10.3389","volume":"12","author":[{"given":"Yanli","family":"Hao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiajing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuni","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"868","DOI":"10.20344\/amp.14292","article-title":"Hysteroscopic findings related with the assessment and treatment of uterine florid cystic endosalpingiosis: a case report and review of all the published cases","volume":"34","author":"Peixinho","year":"2021","journal-title":"Acta Medica Port"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.fertnstert.2011.05.087","article-title":"Incidence of endometriosis by study population and diagnostic method: the ENDO study","volume":"96","author":"Buck Louis","year":"2011","journal-title":"Fertil Steril"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"361","DOI":"10.12659\/AJCR.890921","article-title":"Endosalpingiosis in conjunction with ovarian serous cystadenoma mimicking metastatic ovarian malignancy","volume":"15","author":"Singhania","year":"2014","journal-title":"Am J Case Rep"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1016\/j.ultrasmedbio.2018.03.030","article-title":"Use of contrast-enhanced ultrasound in the assessment of uterine fibroids: a feasibility study","volume":"44","author":"Stoelinga","year":"2018","journal-title":"Ultrasound Med Biol"},{"volume-title":"Ultrasound in obstetrics and gynecology: a practical approach","year":"2014","author":"Abuhamad","key":"ref5"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.ijscr.2015.01.005","article-title":"Cystic adenomyosis spreading into subserosal-peduncolated myoma: how to explain it?","author":"Calagna","year":"2015","journal-title":"Int J Surg Case Rep"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.tjog.2014.11.011","article-title":"Intramural florid cystic endosalpingiosis of the uterus: a case report and review of the literature","volume":"54","author":"Im","year":"2015","journal-title":"Taiwan J Obstet Gynecol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/S0002-9378(16)42561-5","article-title":"Postsalpingectomy endometriosis (Endosalpingiosis)","volume":"20","author":"Sampson","year":"1930","journal-title":"Am J Obstet Gynecol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.humpath.2016.07.003","article-title":"Benign m\u00fcllerian glandular inclusions in men undergoing pelvic lymph node dissection","volume":"57","author":"Gallan","year":"2016","journal-title":"Hum Pathol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.ygyno.2013.12.007","article-title":"Endosalpingiosis as it relates to tubal, ovarian and serous neoplastic tissues: an immunohistochemical study of tubal and M\u00fcllerian antigens","volume":"132","author":"Esselen","year":"2014","journal-title":"Gynecol Oncol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/j.1600-0463.2004.apm1120108.x","article-title":"Tumor-like cystic endosalpingiosis of the uterus with florid epithelial proliferation. 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