{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:39:58Z","timestamp":1787319598221,"version":"build-2736575974"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the efficacy and safety of 650-nm low-level red light (RL) and distant-image therapy (DIT) for myopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A randomized clinical trial. Children aged 8\u201310\u202fyears with a spherical equivalent error (SER) ranging from \u22121 to \u22121.5 diopters (D) were enrolled, and were randomly allocated to the following group: RL, DIT, RL\u202f+\u202fDIT, and control in a 1:1:1:1 ratio. The primary outcomes were changes in SER and axial length (AL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred and sixteen children randomized, girls accounted for 45.69% (53\/116). The median one-year changes in SER were 0.21D (inter-quartile range, IQR: \u22120.03D to 0.46D), \u22120.06D (\u22120.32D to 0.19D), \u22120.08D (\u22120.31D to 0.14D), and \u22120.30D (\u22120.51D to \u22120.09D), respectively, for the RL\u202f+\u202fDIT, RL, DIT, and the control group. The median one-year changes in AL were 0.04\u202fmm (\u22120.03\u202fmm to 0.13\u202fmm), 0.05\u202fmm (\u22120.03\u202fmm to 0.14\u202fmm), 0.30\u202fmm (0.22\u202fmm to 0.37\u202fmm), and 0.42\u202fmm (0.35\u202fmm to 0.49\u202fmm), respectively, for the RL\u202f+\u202fDIT, RL, DIT, and the control group. Fundus photographs revealed no retinal changes across all groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Participants who underwent daily 650-nm low-level red light therapy combined with distant-image screen intervention for 12\u202fmonths demonstrated a significant deceleration in myopia progression, with 79.3% exhibiting potential for reversal of myopia. No safety concerns were identified through OCT and fundus photography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>ClinicalTrials.gov<\/jats:ext-link>\n                      , NCT06683287.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1542620","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T23:01:41Z","timestamp":1742943701000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["One-year changes in axial length and refraction in children using low-level red light and distant-image screen for myopia control: a randomized controlled trial"],"prefix":"10.3389","volume":"12","author":[{"given":"Ke","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1136\/bjo.85.7.855","article-title":"Academic 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