{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:01:20Z","timestamp":1753891280144,"version":"3.41.2"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Kyrieleis plaques are a rare retinal manifestation that has rarely been reported in Behcet's disease uveitis. We report the case of a 41-year-old man who presented with Beh\u00e7et's disease uveitis combined with central serous chorioretinopathy. Laboratory studies showed positive for human leukocyte antigen B51. Polymerase chain reaction analysis of aqueous humor excluded infectious uveitis. Kyrieleis plaques were observed in the bilateral retinal arteries. These plaques persisted in both eyes after half a year of immunosuppressive treatments. Kyrieleis plaques are not limited to infectious uveitis; they can also be associated with Beh\u00e7et's disease uveitis.<\/jats:p>","DOI":"10.3389\/fmed.2025.1544319","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T05:27:44Z","timestamp":1747891664000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Kyrieleis plaques in an unusual Behcet's disease uveitis"],"prefix":"10.3389","volume":"12","author":[{"given":"Jiani","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tantai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangyan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.sjopt.2016.02.005","article-title":"Kyrieleis plaques associated with Herpes Simplex Virus type 1 acute retinal necrosis","volume":"30","author":"Goel","year":"2016","journal-title":"Saudi J Ophthalmol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1080\/08164622.2023.2298793","article-title":"Kyrieleis plaques: recognising a rare presentation of ocular inflammation","volume":"107","author":"Tadepalli","year":"2024","journal-title":"Clini Exp Optomet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1136\/annrheumdis-2018-213225","article-title":"2018 update of the EULAR recommendations for the management of Beh\u00e7et's syndrome","volume":"77","author":"Hatemi","year":"2018","journal-title":"Ann Rheum Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"101216","DOI":"10.1016\/j.preteyeres.2023.101216","article-title":"Risk factors, clinical features and treatment of Beh\u00e7et's disease uveitis","volume":"97","author":"Zhong","year":"2023","journal-title":"Prog Retin Eye Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"383","DOI":"10.22336\/rjo.2021.75","article-title":"Kyrieleis like plaques - atypical presentation of ocular Behcet's disease","volume":"65","author":"Kumar","year":"2021","journal-title":"Romanian J Ophthalmol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/0140-6736(90)92643-V","article-title":"International study group for Beh\u00e7et's disease","volume":"335","year":"1990","journal-title":"Lancet"},{"key":"B7","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s12348-011-0033-y","article-title":"Kyrieleis plaques in cytomegalovirus retinitis","volume":"1","author":"Patel","year":"2011","journal-title":"J Ophthalmic Inflamm Infect."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1001\/archopht.1952.00920010004001","article-title":"Ocular periarteritis nodosa; report of two cases","volume":"48","author":"Wise","year":"1952","journal-title":"AMA Arch Ophthalmol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1136\/bjo.2007.124693","article-title":"Atypical presentation of syphilitic uveitis associated with Kyrieleis plaques","volume":"92","author":"Krishnamurthy","year":"2008","journal-title":"Br J Ophthalmol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1136\/bjophthalmol-2015-308246","article-title":"New appraisals of Kyrieleis plaques: a multimodal imaging study","volume":"101","author":"Pichi","year":"2017","journal-title":"Br J Ophthalmol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"884","DOI":"10.3390\/jcm12030884","article-title":"Adaptive optics of kyrieleis plaques in varicella zoster virus-associated posterior uveitis: a multimodal imaging analysis","volume":"12","author":"Milella","year":"2023","journal-title":"J Clini Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1206959","DOI":"10.3389\/fimmu.2023.1206959","article-title":"Advances in pathogenesis and treatment of ocular involvement in Behcet's disease","volume":"14","author":"Lin","year":"2023","journal-title":"Front Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1097\/MD.0b013e318211bf28","article-title":"Beh\u00e7et disease: evolution of clinical manifestations","volume":"90","author":"Ideguchi","year":"2011","journal-title":"Medicine."},{"key":"B14","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1097\/BOR.0000000000000846","article-title":"The association of Beh\u00e7et's syndrome with HLA-B51 as understood in 2021","volume":"34","author":"Takeno","year":"2022","journal-title":"Curr Opin Rheumatol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3109\/09273948.2015.1136422","article-title":"HLA-B51 Carriers are susceptible to ocular symptoms of Beh\u00e7et disease and the association between the two becomes stronger towards the east along the silk road: a literature survey","volume":"25","author":"Horie","year":"2017","journal-title":"Ocul Immunol Inflamm."},{"key":"B16","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1080\/14397595.2019.1649103","article-title":"The influence of HLA-B51 on clinical manifestations among Japanese patients with Beh\u00e7et's disease: a nationwide survey","volume":"30","author":"Mizuki","year":"2020","journal-title":"Modern Rheumatol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"e47060","DOI":"10.7759\/cureus.47060","article-title":"Atypical Ocular Toxoplasmosis: Multifocal Segmental Retinal Arteritis (Kyrieleis Arteritis) and Peripheral Choroidal Leision","volume":"15","author":"Khadamy","year":"2023","journal-title":"Cureus."},{"key":"B18","doi-asserted-by":"publisher","first-page":"609148","DOI":"10.3389\/fphar.2021.609148","article-title":"The efficacy of adalimumab as an initial treatment in patients with Beh\u00e7et's retinal vasculitis","volume":"12","author":"Yang","year":"2021","journal-title":"Front Pharmacol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.ophtha.2018.12.048","article-title":"Long-term visual outcomes and causes of vision loss in chronic central serous chorioretinopathy","volume":"126","author":"Mrejen","year":"2019","journal-title":"Ophthalmology."},{"key":"B20","doi-asserted-by":"publisher","first-page":"100865","DOI":"10.1016\/j.preteyeres.2020.100865","article-title":"Central serous chorioretinopathy: an update on risk factors, pathophysiology and imaging modalities","volume":"79","author":"Kaye","year":"2020","journal-title":"Prog Retin Eye Res."},{"key":"B21","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s12886-022-02330-0","article-title":"577 nm subthreshold micropulse laser treatment for acute central serous chorioretinopathy: a comparative study","volume":"22","author":"Long","year":"2022","journal-title":"BMC Ophthalmol."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1544319\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T05:27:45Z","timestamp":1747891665000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1544319\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,22]]},"references-count":21,"alternative-id":["10.3389\/fmed.2025.1544319"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1544319","relation":{},"ISSN":["2296-858X"],"issn-type":[{"type":"electronic","value":"2296-858X"}],"subject":[],"published":{"date-parts":[[2025,5,22]]},"article-number":"1544319"}}