{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:00:39Z","timestamp":1753891239374,"version":"3.41.2"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Waldenstr\u00f6m\u2019s Macroglobulinemia (WM) is a rare lymphoproliferative disorder characterized by the proliferation of lymphoplasmacytic cells producing monoclonal immunoglobulin M (IgM). Extra-hematopoietic involvement, although rare, can affect the gastrointestinal tract in approximately 4% of cases and the lungs in 3\u20135% of cases. This case highlights the diversity of extramedullary manifestations in WM and underscores the importance of performing pulmonary and gastrointestinal endoscopies with systematic biopsies for optimal disease management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>We report the case of a 60-year-old Haitian man diagnosed with WM in January 2023 following an episode of acute respiratory failure. Biopsies revealed lymphoplasmacytic infiltration in both the bronchial and gastrointestinal mucosa. Biopsies revealed lymphoplasmacytic infiltration in both the bronchial and gastrointestinal mucosa, despite normal macroscopic findings during gastrointestinal endoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case emphasizes the importance of systematic biopsies during endoscopic examinations, even in the absence of visible lesions, to detect lymphoplasmacytic infiltration in WM. These findings could help in changing the approach to disease management and improving patient outcomes.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1551600","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T05:13:31Z","timestamp":1746594811000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Pulmonary and gastrointestinal involvement in a rare case of Waldenstr\u00f6m\u2019s Macroglobulinemia in French Guiana"],"prefix":"10.3389","volume":"12","author":[{"given":"Houari","family":"Aissaoui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Gaudard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghazi","family":"Hadj Amara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alolia","family":"Aboikoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanna","family":"Lingibe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Louvel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e7566","DOI":"10.7759\/cureus.7566","article-title":"Chylothorax as an initial manifestation of Waldenstr\u00f6m macroglobulinemia.","volume":"12","author":"Rodriguez Botero","year":"2020","journal-title":"Cureus."},{"key":"B2","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1097\/00007611-199807000-00017","article-title":"The lung and Waldenstr\u00f6m\u2019s macroglobulinemia.","volume":"91","author":"Fadil","year":"1998","journal-title":"South Med J."},{"key":"B3","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1111\/j.0954-6820.1944.tb03955.x","article-title":"Incipient myelomatosis or \u201cessential\u201d hyperglobulinemia with fibrinogen peia-\u201dnew syndrome\u201d?","volume":"117","author":"Waldenstr\u00f6m","year":"1944","journal-title":"Acta Med Scandinav."},{"key":"B4","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.bulcan.2022.08.012","article-title":"[Waldenstr\u00f6m disease: News and perspectives in 2022].","volume":"110","author":"Bouclet","year":"2023","journal-title":"Bull Cancer."},{"key":"B5","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/s1470-2045(03)01246-4","article-title":"Waldenstr\u00f6m macroglobulinaemia.","volume":"4","author":"Ghobrial","year":"2003","journal-title":"Lancet Oncol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.6004\/jnccn.2012.0128","article-title":"Waldenstr\u00f6m\u2019s macroglobulinemia\/lymphoplasmacytic lymphoma, version 2.2013.","volume":"10","author":"Anderson","year":"2012","journal-title":"J Natl Compr Canc Netw."},{"key":"B7","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.blre.2015.03.001","article-title":"Waldenstr\u00f6m macroglobulinemia: What a hematologist needs to know.","volume":"29","author":"Kapoor","year":"2015","journal-title":"Blood Rev."},{"key":"B8","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1002\/ajh.23880","article-title":"Extramedullary Waldenstr\u00f6m macroglobulinemia.","volume":"90","author":"Banwait","year":"2015","journal-title":"Am J Hematol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/0002-9343(72)90163-5","article-title":"Waldenstr\u00f6m\u2019s macroglobulinemia. 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