{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T09:30:06Z","timestamp":1773480606365,"version":"3.50.1"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the factors associated with the recurrence of colorectal polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on polyp recurrence and related factors, including gender, age, BMI, family history, smoking history, alcohol consumption history, gallbladder disease history, food allergy, polyp size, number, and pathological classification, <jats:italic>Helicobacter pylori<\/jats:italic> (Hp) infection, parathyroid hormone, gastrin, and blood lipid levels, were collected as exposure factors. Polyp recurrence was used as the outcome measure. Logistic regression analysis was used to evaluate risk and protective factors for colorectal polyp recurrence. The diagnostic performance of the identified risk factor model was assessed using ROC curve analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 318 patients, 170 experienced polyp recurrence, while 148 did not. Logistic regression analysis revealed that gender (OR = 1.927, 95% CI = 1.134\u20133.276, <jats:italic>P<\/jats:italic> = 0.015), age<jats:sub>60\u201380<\/jats:sub><jats:sub>years<\/jats:sub> (OR = 3.228, 95% CI = 1.846\u20135.647, <jats:italic>P<\/jats:italic> &amp;lt; 0.001), history of gallbladder disease (OR = 2.011, 95% CI = 1.147\u20133.523, <jats:italic>P<\/jats:italic> = 0.015), food allergy (OR = 2.246, 95% CI = 1.211\u20134.545, <jats:italic>P<\/jats:italic> = 0.012), pathological classification (OR = 5.023, 95% CI = 2.932\u20138.606, <jats:italic>P<\/jats:italic> &amp;lt; 0.001), and Hp infection (OR = 1.970, 95% CI = 1.171\u20133.312, <jats:italic>P<\/jats:italic> = 0.011) were positively associated with polyp recurrence. Conversely, polyp size (OR = 0.324, 95% CI = 0.127\u20130.827, <jats:italic>P<\/jats:italic> = 0.018) was negatively associated with recurrence. Logit(p) = \u22122.459 + 0.656 \u00d7 Gender + 1.172 \u00d7 Age 61\u201380 years + 0.698 \u00d7 Gallbladder Disease + 0.853 \u00d7 Food Allergy\u22121.127 \u00d7 Polyp Size + 1.164 \u00d7 Pathological Classification + 0.678 \u00d7 Hp Infection. The risk prediction model can be used to predict post-surgical recurrence of colorectal polyps with a sensitivity of 0.88 and specificity of 0.56. The cutoff value for this odds prediction model is 0.44.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elderly (61\u201380 years old) male patients with adenomatous colorectal cancer and the history of <jats:italic>Helicobacter pylori<\/jats:italic> (Hp) infection, gallbladder disease and food allergy have higher odds to experience recurrence after surgical resection. On the contrary, those patients with a larger polyp size (\u22652 cm) are less odds to experience recurrence. Patients with a risk prediction model value greater than or equal to 0.44 have increased odds to experience postoperative recurrence.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1553194","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T05:47:25Z","timestamp":1750225645000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Study on the risk factors for colorectal polyp recurrence: a cross-sectional retrospective cohort study"],"prefix":"10.3389","volume":"12","author":[{"given":"Fang","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengge","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boran","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuewei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongrong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Xin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianbo","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanqin","family":"Bian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.1053\/j.gastro.2020.08.050","article-title":"Endoscopic recognition and management strategies for malignant colorectal polyps: Recommendations of the US multi-society task force on colorectal cancer.","volume":"159","author":"Shaukat","year":"2020","journal-title":"Gastroenterology."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1056\/NEJM199312303292701","article-title":"Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup.","volume":"329","author":"Winawer","year":"1993","journal-title":"N Engl J Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/S2468-1253(22)00090-5","article-title":"Serrated polyp detection and risk of interval post-colonoscopy colorectal cancer: A population-based study.","volume":"7","author":"van Toledo","year":"2022","journal-title":"Lancet Gastroenterol Hepatol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3322\/caac.21166","article-title":"Cancer statistics, 2013.","volume":"63","author":"Siegel","year":"2013","journal-title":"CA Cancer J Clin."},{"key":"B5","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s10350-003-0054-1","article-title":"Colorectal adenoma characteristics as predictors of recurrence.","volume":"47","author":"Bonithon-Kopp","year":"2004","journal-title":"Dis Colon Rectum."},{"key":"B6","doi-asserted-by":"publisher","first-page":"goab038","DOI":"10.1093\/gastro\/goab038","article-title":"Risk factors for recurrence of colorectal conventional adenoma and serrated polyp.","volume":"10","author":"Chi","year":"2022","journal-title":"Gastroenterol Rep."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e50990","DOI":"10.1371\/journal.pone.0050990","article-title":"Predictors of colorectal polyp recurrence after the first polypectomy in private practice settings: A cohort study.","volume":"7","author":"Viel","year":"2012","journal-title":"PLoS One."},{"key":"B8","doi-asserted-by":"publisher","first-page":"823263","DOI":"10.3389\/fonc.2022.823263","article-title":"Risk of adenoma recurrence after polypectomy in patients younger than 50 years vs. 50 years old and over with diminutive or small adenomas.","volume":"12","author":"Cai","year":"2022","journal-title":"Front Oncol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.cgh.2022.12.006","article-title":"Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines.","volume":"21","author":"Cavestro","year":"2023","journal-title":"Clin Gastroenterol Hepatol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1053\/j.gastro.2020.01.004","article-title":"Risk factors for early-onset colorectal cancer.","volume":"159","author":"Low","year":"2020","journal-title":"Gastroenterology."},{"key":"B11","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1053\/j.gastro.2019.07.055","article-title":"Epidemiology and mechanisms of the increasing incidence of colon and rectal cancers in young adults.","volume":"158","author":"Stoffel","year":"2020","journal-title":"Gastroenterology."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e2130433","DOI":"10.1001\/jamanetworkopen.2021.30433","article-title":"Trends in the incidence of early-onset colorectal adenocarcinoma among black and white US Residents Aged 40 to 49 Years, 2000-2017.","volume":"4","author":"Montminy","year":"2021","journal-title":"JAMA Netw Open."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1136\/gutjnl-2020-323450","article-title":"Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women.","volume":"70","author":"Hur","year":"2021","journal-title":"Gut."},{"key":"B14","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1053\/j.gastro.2021.03.028","article-title":"Simple sugar and sugar-sweetened beverage intake during adolescence and risk of colorectal cancer precursors.","volume":"161","author":"Joh","year":"2021","journal-title":"Gastroenterology."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1080\/01635581.2020.1804951","article-title":"Excessive body fat at a young age increases the risk of colorectal cancer: A systematic review and meta-analysis.","volume":"73","author":"Lei","year":"2021","journal-title":"Nutr Cancer."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1053\/j.gastro.2021.12.239","article-title":"Associations of body mass index at different ages with early-onset colorectal cancer.","volume":"162","author":"Li","year":"2022","journal-title":"Gastroenterology."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.cgh.2021.01.037","article-title":"Risk factors for early-onset colorectal cancer: A systematic review and meta-analysis.","volume":"20","author":"O\u2019Sullivan","year":"2022","journal-title":"Clin Gastroenterol Hepatol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1159\/000521932","article-title":"Diet and lifestyle habits in early-onset colorectal cancer: A pilot case-control study.","volume":"40","author":"Puzzono","year":"2022","journal-title":"Dig Dis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1038\/s41416-021-01665-7","article-title":"Oral antibiotic use and early-onset colorectal cancer: Findings from a case-control study using a national clinical database.","volume":"126","author":"McDowell","year":"2022","journal-title":"Br J Cancer."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1053\/j.gastro.2021.07.002","article-title":"Total vitamin D intake and risks of early-onset colorectal cancer and precursors.","volume":"161","author":"Kim","year":"2021","journal-title":"Gastroenterology."},{"key":"B21","doi-asserted-by":"publisher","first-page":"458","DOI":"10.14309\/ajg.0000000000001122","article-title":"ACG Clinical Guidelines: Colorectal Cancer Screening 2021.","volume":"116","author":"Shaukat","year":"2021","journal-title":"Am J Gastroenterol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1055\/a-2304-3219","article-title":"Colorectal polypectomy and endoscopic mucosal resection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2024.","volume":"56","author":"Ferlitsch","year":"2024","journal-title":"Endoscopy."},{"key":"B23","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1136\/gutjnl-2013-306503","article-title":"An updated Asia Pacific Consensus Recommendations on colorectal cancer screening.","volume":"64","author":"Sung","year":"2015","journal-title":"Gut."},{"key":"B24","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1136\/gutjnl-2017-315131","article-title":"Management of patients on antithrombotic agents undergoing emergency and elective endoscopy: Joint Asian Pacific Association of Gastroenterology (APAGE) and Asian Pacific Society for Digestive Endoscopy (APSDE) practice guidelines.","volume":"67","author":"Chan","year":"2018","journal-title":"Gut."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2992","DOI":"10.1002\/ijc.32055","article-title":"Global trends in colorectal cancer mortality: Projections to the year 2035.","volume":"144","author":"Araghi","year":"2019","journal-title":"Int J Cancer."},{"key":"B26","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/0092-8674(90)90186-i","article-title":"A genetic model for colorectal tumorigenesis.","volume":"61","author":"Fearon","year":"1990","journal-title":"Cell."},{"key":"B27","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1053\/j.gastro.2012.06.001","article-title":"Guidelines for colonoscopy surveillance after screening and polypectomy: A consensus update by the US Multi-Society Task Force on Colorectal Cancer.","volume":"143","author":"Lieberman","year":"2012","journal-title":"Gastroenterology."},{"key":"B28","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s10620-015-3600-5","article-title":"The impact of screening on colorectal cancer mortality and incidence: Has it really made a difference?","volume":"60","author":"Zauber","year":"2015","journal-title":"Dig Dis Sci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer.","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature."},{"key":"B30","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.ijsu.2016.06.048","article-title":"Can gallbladder polyps predict colorectal adenoma or even neoplasia? A systematic review.","volume":"33","author":"Stergios","year":"2016","journal-title":"Int J Surg."},{"key":"B31","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.jaci.2013.11.020","article-title":"Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment.","volume":"133","author":"Sicherer","year":"2014","journal-title":"J Allergy Clin Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3322\/canjclin.56.3.143","article-title":"Guidelines for colonoscopy surveillance after polypectomy: A consensus update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society.","volume":"56","author":"Winawer","year":"2006","journal-title":"CA Cancer J Clin."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.4240\/wjgs.v16.i4.1008","article-title":"Relationship between Helicobacter pylori infection and colorectal polyp\/colorectal cancer.","volume":"16","author":"Liu","year":"2024","journal-title":"World J Gastrointest Surg."},{"key":"B34","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/nrc2857","article-title":"Helicobacter pylori: Gastric cancer and beyond.","volume":"10","author":"Polk","year":"2010","journal-title":"Nat Rev Cancer."},{"key":"B35","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1001\/jama.291.2.187","article-title":"Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: A randomized controlled trial.","volume":"291","author":"Wong","year":"2004","journal-title":"JAMA."},{"key":"B36","doi-asserted-by":"publisher","first-page":"8182","DOI":"10.3748\/wjg.v27.i47.8182","article-title":"Real-world local recurrence rate after cold polypectomy in colorectal polyps less than 10 mm using propensity score matching.","volume":"27","author":"Saito","year":"2021","journal-title":"World J Gastroenterol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1002\/mc.22387","article-title":"Calcium\/magnesium intake ratio, but not magnesium intake, interacts with genetic polymorphism in relation to colorectal neoplasia in a two-phase study.","volume":"55","author":"Zhu","year":"2016","journal-title":"Mol Carcinog."},{"key":"B38","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.bbamcr.2009.01.004","article-title":"Expression of gastrin precursors by CD133-positive colorectal cancer cells is crucial for tumour growth.","volume":"1793","author":"Ferrand","year":"2009","journal-title":"Biochimica Biophy Acta."},{"key":"B39","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1186\/s12944-020-01388-3","article-title":"Elevated serum triglyceride predicts recurrence of colorectal polyps in patients with advanced adenomas.","volume":"19","author":"Liu","year":"2020","journal-title":"Lipids Health Dis."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1553194\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T05:47:26Z","timestamp":1750225646000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1553194\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,18]]},"references-count":39,"alternative-id":["10.3389\/fmed.2025.1553194"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1553194","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,18]]},"article-number":"1553194"}}