{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T05:33:04Z","timestamp":1783747984149,"version":"3.55.0"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the surgical effect and safety of a novel technique for the excision of intraocular choroidal melanoma in order to reduce the risk of serious adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study analyzed 23 patients with choroidal melanoma (23 eyes) from January 2016 to December 2022. Instead of the standard peripheral retina incision and subsequent tumor removal, we performed phacoemulsification and complete vitrectomy with tumor and overlying retina removal under high intraocular pressure. Without further retinal reattachment, the basal sclera is preserved. The tumor was resected, leaving 1\u20132 mm of the surrounding normal retina and choroid. The resection edge was further treated with laser therapy, which was followed by the replacement of heavy water with silicone oil. Finally, the vitreous cavity was filled with silicone oil. The median operation time was 1.5 h (1.2\u20132.5 h). Complete ophthalmic examinations were performed 1 day, 1 week, and 1, 3, and 6 months postoperatively. Systemic examination was conducted every 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median duration for all surgeries was 1.5 h (range: 1.2\u20132.5 h). Minor bleeding occurred at the mass resection margin intraoperatively, and the minimal-to-little hyphema observed on postoperative day 1 in all patients was absorbed 3\u20137 days later. No retinal detachment was noted at a mean follow-up of 42.5 \u00b1 6.9 (range, 36\u201360) months. The best-corrected visual acuity at the last follow-up was lower than that before surgery (<jats:italic>P<\/jats:italic> = 0.001), One patient required enucleation due to intraocular recurrence, and one patient died from metastatic choroidal melanoma. The remaining patients remained healthy during the follow-up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maintaining a vitreous cavity filled with half air and half heavy water while excising the choroidal tumor and the overlying retina is a simple, effective, and safe surgical approach.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1554581","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T05:47:09Z","timestamp":1748584029000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The surgical effect and safety of a novel intraocular choroidal melanoma resection"],"prefix":"10.3389","volume":"12","author":[{"given":"Yulun","family":"Ou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianfen","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1136\/jmedgenet-2011-100156","article-title":"Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers.","volume":"48","author":"Abdel-Rahman","year":"2011","journal-title":"J Med Genet."},{"key":"B2","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.ophtha.2003.05.007","article-title":"Histopathology of eyes enucleated after endoresection of choroidal melanoma.","volume":"111","author":"Hadden","year":"2004","journal-title":"Ophthalmology."},{"key":"B3","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/S0161-6420(03)00078-2","article-title":"Incidence of uveal melanoma in the United States: 1973-1997.","volume":"110","author":"Singh","year":"2003","journal-title":"Ophthalmology."},{"key":"B4","doi-asserted-by":"publisher","first-page":"153","DOI":"10.2147\/OPTH.S120530","article-title":"Ocular melanoma-when you have seen one, you have not seen them all: A clinical outcome study from the Surveillance, Epidemiology and End Results (SEER) database (1973-2012).","volume":"11","author":"Mahendraraj","year":"2017","journal-title":"Clin Ophthalmol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1097\/IIO.0000000000000057","article-title":"Uveal melanoma: Evidence for adjuvant therapy.","volume":"55","author":"Choudhary","year":"2015","journal-title":"Int Ophthalmol Clin."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1002\/(sici)1097-0142(19981015)83:8&<1664::aid-cncr23&>3.0.co;2-g","article-title":"The National Cancer Data Base report on cutaneous and noncutaneous melanoma: A summary of 84,836 cases from the past decade. 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