{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:02:18Z","timestamp":1753891338283,"version":"3.41.2"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the effects of general and regional anesthesia on clinical outcomes following primary total hip arthroplasty (THA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study using data from the Korean National Health Insurance Research Database included 1,522 patients who underwent THA under general anesthesia (<jats:italic>n<\/jats:italic>\u202f=\u202f640) or regional anesthesia (<jats:italic>n<\/jats:italic>\u202f=\u202f882) between 2002 and 2015. We compared the mortality and complication rates within 30\u202fdays after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prosthesis failure (1.56% vs. 0.45%, <jats:italic>p<\/jats:italic>\u202f=\u202f0.025), admission to the intensive care unit (9.53 vs. 5.44%, <jats:italic>p\u202f=<\/jats:italic> 0.0023), and total cost (\u20a97,332,515 vs. \u20a96,833,295, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.0001) were higher in the general anesthesia group than in the regional anesthesia group. No significant differences were observed in mortality (0.94% vs. 0.57%, <jats:italic>p<\/jats:italic>\u202f=\u202f0.54), transfusion rate (81.1% vs. 80.9%<jats:italic>, p<\/jats:italic>\u202f=\u202f0.94), length of hospital stay (45 vs. 45\u202fdays, <jats:italic>p<\/jats:italic>\u202f=\u202f0.23), or other complications between the groups. Similar results were observed in propensity-score matched analysis (<jats:italic>n<\/jats:italic>\u202f=\u202f640 patients per group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study showed that both anesthesia types resulted in comparable mortality and complication rates in patients who underwent THA, but the costs differed.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1557053","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T07:19:44Z","timestamp":1742195984000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparing general and regional anesthesia in patients undergoing primary total hip arthroplasty: analysis of national health insurance data in Korea"],"prefix":"10.3389","volume":"12","author":[{"given":"Seungyoung","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunjin","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Kyoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fletcher A.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Euiheon","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YongHun","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e99804","DOI":"10.1371\/journal.pone.0099804","article-title":"Total hip replacement for the treatment of end stage arthritis of the hip: a systematic review and meta-analysis","volume":"9","author":"Tsertsvadze","year":"2014","journal-title":"PLoS One"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1177\/2151458515583515","article-title":"The effect of advancing age on total joint replacement 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