{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T19:07:08Z","timestamp":1754161628292,"version":"3.41.2"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>A 47-year-old married woman presented with abdominal discomfort, distension, and nausea following a two-day episode of constipation accompanied by reduced urine output. Upon her admission, a physical assessment indicated tachycardia and abdominal sensitivity, while imaging examinations corroborated gastrointestinal perforation along with signs of acute diffuse peritonitis. The patient had a prior history of Crohn's disease and had been off medication for over a year. The initial surgical intervention entailed bowel resection and adhesiolysis; however, postoperative complications arose, prompting a second operation due to suspected anastomotic leakage and a severe infection. In spite of these challenges, the patient received intensive care, nutritional support, and treatment for short bowel syndrome. Over span of a month, her health significantly improved, and she was ultimately discharged with ongoing management for her Crohn's disease. This case underscores the intricacies involved in addressing intestinal perforations in patients with pre-existing Crohn's disease and highlights the imperative for prompt surgical action and comprehensive postoperative care.<\/jats:p>","DOI":"10.3389\/fmed.2025.1557305","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T05:20:56Z","timestamp":1753766456000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: A female patient with gastrointestinal perforation, acute diffuse peritonitis, and Crohn's disease needs homeostasis management"],"prefix":"10.3389","volume":"12","author":[{"given":"Dai-Liang","family":"Fei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan-Neng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Liang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41572-020-0156-2","article-title":"Crohn's disease","volume":"6","author":"Roda","year":"2020","journal-title":"Nat Rev Dis Primers."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1016\/S0140-6736(23)02586-2","article-title":"Crohn's disease","volume":"403","author":"Dolinger","year":"2024","journal-title":"Lancet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"268","DOI":"10.3760\/cma.j.cn441530-20221123-00487","article-title":"Diagnostic value of identifying location and amount of free gas in the abdominal cavity by multidetector computed tomography in patients with acute gastrointestinal perforation","volume":"27","author":"Liang","year":"2024","journal-title":"Zhonghua Wei Chang Wai Ke Za Zhi."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1007\/s10637-021-01135-0","article-title":"Gastrointestinal perforation following dabrafenib and trametinib administration in non-small cell lung carcinoma with BRAF V600E mutation: a case report and literature review","volume":"39","author":"Shimada","year":"2021","journal-title":"Invest New Drugs."},{"key":"B5","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1093\/aje\/kwae448","article-title":"Assessing the risk of gastrointestinal perforation associated with COVID-19: a self-controlled case series study","author":"Okura","year":"2024","journal-title":"Am J Epidemiol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1097\/RCT.0000000000000955","article-title":"Multidetector computed tomography findings of adhesive internal hernias","volume":"44","author":"Zhang","year":"2020","journal-title":"J Comput Assist Tomogr."},{"key":"B7","doi-asserted-by":"publisher","first-page":"665022","DOI":"10.3389\/fped.2021.665022","article-title":"Jejunoileal atresia: a national cohort study","volume":"9","author":"Schmedding","year":"2021","journal-title":"Front Pediatr."},{"key":"B8","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1186\/s12893-022-01849-9","article-title":"Outcome of Santulli enterostomy in patients with immaturity of ganglia: single institutional experience from a case series","volume":"22","author":"Lin","year":"2022","journal-title":"BMC Surg."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.12688\/f1000research.140021.1","article-title":"Case report: acute peritonitis inaugurating Crohn's disease with spontaneous perforation in the peritoneal cavity","volume":"12","author":"Belhadj","year":"2023","journal-title":"F1000Research"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1557305\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T05:21:18Z","timestamp":1753766478000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1557305\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,29]]},"references-count":9,"alternative-id":["10.3389\/fmed.2025.1557305"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1557305","relation":{},"ISSN":["2296-858X"],"issn-type":[{"type":"electronic","value":"2296-858X"}],"subject":[],"published":{"date-parts":[[2025,7,29]]},"article-number":"1557305"}}