{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:00:46Z","timestamp":1753891246246,"version":"3.41.2"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Synchronous neoplasms of the stomach are uncommon. Here we presented an unusual case with coexistence of neuroendocrine tumor and signet ring cell carcinoma in the stomach. Gastroscopic examination of a 66-year-old male patient showed a submucosal tumor-like mass with an ulcer on the surface located in the anterior wall of the lower segment of gastric body, confirmed by subsequent biopsy as a signet ring cell carcinoma. Moreover, we also found a slightly yellowish 6-mm protrusion simulating a polyp located in the lesser curvature of the upper segment of gastric body, and biopsy revealed it was a neuroendocrine tumor. The patient underwent a total gastrectomy with a standard D2 lymph node dissection. Pathohistological results led to the final diagnosis of synchronous neoplasms in the stomach, including a signet ring cell carcinoma and a neuroendocrine tumor.<\/jats:p>","DOI":"10.3389\/fmed.2025.1561231","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T05:26:40Z","timestamp":1746682000000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Synchronous neuroendocrine tumor and signet ring cell carcinoma in the stomach: a case report and review of literature"],"prefix":"10.3389","volume":"12","author":[{"given":"Jian","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanlin","family":"Mu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingmei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"26","DOI":"10.5114\/pg.2018.80001","article-title":"Epidemiology of gastric cancer: global trends, risk factors and prevention","volume":"14","author":"Rawla","year":"2019","journal-title":"Prz Gastroenterol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e29304","DOI":"10.1097\/MD.0000000000029304","article-title":"The current management and biomarkers of immunotherapy in advanced gastric cancer","volume":"101","author":"Chang","year":"2022","journal-title":"Medicine"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.21147\/j.issn.1000-9604.2018.01.01","article-title":"Cancer incidence and mortality in China, 2014","volume":"30","author":"Chen","year":"2018","journal-title":"Chin J Cancer Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s10120-013-0234-1","article-title":"Clinicopathological characteristics and prognosis of signet ring cell carcinoma of the stomach","volume":"17","author":"Kwon","year":"2014","journal-title":"Gastric Cancer"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1245\/s10434-023-14712-9","article-title":"Management of Gastric Neuroendocrine Tumors: a review","volume":"31","author":"Sok","year":"2024","journal-title":"Ann Surg Oncol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"7216","DOI":"10.3748\/wjg.v12.i44.7216","article-title":"Synchronous occurrence of carcinoid, signet-ring cell carcinoma and heterotopic pancreatic tissue in stomach: a case report and literature review","volume":"12","author":"Yang","year":"2006","journal-title":"World J Gastroenterol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.clinre.2018.11.012","article-title":"Synchronous neuroendocrine tumor and signet-ring cell carcinoma in the stomach","volume":"43","author":"He","year":"2019","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"188","DOI":"10.3390\/nu17010188","article-title":"Progress and challenges in integrating nutritional care into oncology practice: results from a National Survey on behalf of the Nutri Onc research group","volume":"17","author":"De Felice","year":"2025","journal-title":"Nutrients"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1007\/s10555-020-09925-3","article-title":"Gastric cancer: a comprehensive review of current and future treatment strategies","volume":"39","author":"Sexton","year":"2020","journal-title":"Cancer Metastasis Rev"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1038\/ajg.2009.736","article-title":"A cohort study of missed and new cancers after esophagogastroduodenoscopy","volume":"105","author":"Raftopoulos","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1111\/j.1445-2197.2009.05108.x","article-title":"Missed lesions in synchronous multiple gastric cancer","volume":"80","author":"Ha","year":"2010","journal-title":"ANZ J Surg"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1443-1661.2012.01339.x","article-title":"Missed synchronous gastric neoplasm with endoscopic submucosal dissection for gastric neoplasm: experience in our hospital","volume":"25","author":"Kim","year":"2013","journal-title":"Dig Endosc"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s101200050045","article-title":"Gastric carcinoma resembling submucosal tumor","volume":"2","author":"Umehara","year":"1999","journal-title":"Gastric Cancer"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.4251\/wjgo.v14.i8.1406","article-title":"Poorly cohesive cells gastric carcinoma including signet-ring cell cancer: updated review of definition, classification and therapeutic management","volume":"14","author":"Drubay","year":"2022","journal-title":"World J Gastrointest Oncol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s00423-021-02314-6","article-title":"Signet ring cell cancer of stomach and gastro-esophageal junction: molecular alterations, stage-stratified treatment approaches, and future challenges","volume":"407","author":"Kumar","year":"2022","journal-title":"Langenbeck's Arch Surg"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"741","DOI":"10.4253\/wjge.v7.i7.741","article-title":"Endoscopic features of early-stage signet-ring-cell carcinoma of the stomach","volume":"7","author":"Phalanusitthepha","year":"2015","journal-title":"World J Gastrointest Endosc"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1159\/000524792","article-title":"Three types of subepithelial lesion-like gastric Cancer including a new entity of gastric adenocarcinoma","volume":"16","author":"Yamamoto","year":"2022","journal-title":"Case Rep Gastroenterol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"421","DOI":"10.5946\/ce.2012.45.4.421","article-title":"Signet-ring cell carcinoma mimicking gastric gastrointestinal stromal tumor confirmed by endoscopic ultrasound-guided tru-cut biopsy","volume":"45","author":"Kim","year":"2012","journal-title":"Clin Endosc"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1159\/000506448","article-title":"Signet ring cell carcinoma mimicking gastric gastrointestinal stromal tumor: a case report","volume":"13","author":"Lee","year":"2020","journal-title":"Case Rep Oncol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.3390\/medicina59101757","article-title":"Therapeutic challenges for gastric neuroendocrine neoplasms: take it or leave it?","volume":"59","author":"Cavalcoli","year":"2023","journal-title":"Medicina"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"5489","DOI":"10.7150\/thno.42814","article-title":"Molecular characteristics of synchronous multiple gastric cancer","volume":"10","author":"Wang","year":"2020","journal-title":"Theranostics"},{"key":"ref22","first-page":"1855","article-title":"Synchronous large gastrointestinal stromal tumor and adenocarcinoma in the stomach treated with Imatinib Mesylate followed by Total gastrectomy","volume":"36","author":"Namikawa","year":"2016","journal-title":"Anticancer Res"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1177\/1066896907302369","article-title":"Synchronous gastric gastrointestinal stromal tumor and signet-ring cell adenocarcinoma: a case report","volume":"15","author":"Lee","year":"2007","journal-title":"Int J Surg Pathol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1097\/00007611-199704000-00014","article-title":"Gastric adenocarcinoma and low-grade B-cell lymphoma of mucosa-associated lymphoid tissue","volume":"90","author":"Hardman","year":"1997","journal-title":"South Med J"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1055\/s-2007-1018130","article-title":"Gastroscopic screening for gastric carcinoids and carcinoma in pernicious anemia","volume":"20","author":"Sj\u00f6blom","year":"1988","journal-title":"Endoscopy"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1080\/00365521.2022.2081061","article-title":"Gastric lesions in patients with autoimmune metaplastic atrophic gastritis: a retrospective study in a single center","volume":"57","author":"Hu","year":"2022","journal-title":"Scand J Gastroenterol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1007\/s10120-014-0393-8","article-title":"Gastric cancer in patients with type I gastric carcinoids","volume":"18","author":"Lahner","year":"2015","journal-title":"Gastric Cancer"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.2169\/internalmedicine.2679-19","article-title":"Synchronous early gastric Cancer\/neuroendocrine tumor associated with autoimmune gastritis completely resected with endoscopic submucosal dissection","volume":"58","author":"Kubo","year":"2019","journal-title":"Intern Med"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"3378","DOI":"10.1210\/jc.2007-0283","article-title":"Carcinogenic hypergastrinemia: signet-ring cell carcinoma in a patient with multiple endocrine neoplasia type 1 with Zollinger-Ellison's syndrome","volume":"92","author":"Schott","year":"2007","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1561231\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T05:26:41Z","timestamp":1746682001000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1561231\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,8]]},"references-count":29,"alternative-id":["10.3389\/fmed.2025.1561231"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1561231","relation":{},"ISSN":["2296-858X"],"issn-type":[{"type":"electronic","value":"2296-858X"}],"subject":[],"published":{"date-parts":[[2025,5,8]]},"article-number":"1561231"}}