{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:53:46Z","timestamp":1792803226745,"version":"4.5.0"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The incidence of hyperlipidemic acute pancreatitis (HLAP) has been increasing yearly, presenting a younger demographic and high mortality rates. Early assessment of severity is essential for improving treatment strategies and outcomes. Various serum biomarkers, including neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), have shown prognostic value in inflammatory conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to evaluate NLR, PLR, procalcitonin (PCT), and D-dimer (D-D) as biomarkers in assessing HLAP severity, identify independent predictors factors for moderate-to-severe HLAP, and provide evidence for tailored therapeutic interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on 145 HLAP patients admitted between mid-2021 and mid-2023 at Jining No. 1 People's Hospital. Patients were categorized into mild HLAP and moderate-to-severe HLAP groups based on severity. Clinical and biochemical data were analyzed using SPSS 26.0, and the diagnostic efficacy of NLR, PLR, PCT, and D-D was evaluated via Receiver Operating Characteristic (ROC) curve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Elevated levels of NLR, PLR, PCT, and D-D were identified as independent predictors for moderate-to-severe HLAP. The combined ROC curve for these biomarkers yielded an area under the curve (AUC) of 0.898 (95% CI: 0.841\u20130.956), with sensitivity and specificity of 0.818 and 0.892, respectively, outperforming individual biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The combined assessment of NLR, PLR, PCT, and D-D is a simple, efficient, and cost-effective method for early HLAP severity evaluation. Further large-scale studies are warranted to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1561255","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T01:13:30Z","timestamp":1746580410000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["The value of NLR, PLR, PCT, and D-D levels in assessing the severity of hyperlipidemic acute 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