{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T08:11:38Z","timestamp":1759133498311,"version":"3.41.2"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:italic>Elizabethkingia miricola<\/jats:italic> is a rarely encountered pathogen in clinical settings, predominantly causing infections in immunocompromised individuals. To advance the understanding of <jats:italic>E. miricola<\/jats:italic> infection, we present a case of <jats:italic>E. miricola<\/jats:italic> infection and conduct a literature review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report a case of pulmonary infection caused by <jats:italic>E. miricola<\/jats:italic> in a 90-year-old trauma patient, marking the first documented instance of treatment with eravacycline. We also conducted a systematic review of the relevant literature. A comprehensive search was performed using the PubMed and Web of Science databases up to November 2024. A qualitative synthesis was conducted on all available case reports and case series related to <jats:italic>E. miricola<\/jats:italic> infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 63 cases from 21 studies were included in this systematic review. According to these case reports, infections caused by <jats:italic>E. miricola<\/jats:italic> most commonly occur in the lungs (34\/63), bloodstream (6\/63), and urinary tract (4\/63). Risk factors for <jats:italic>E. miricola<\/jats:italic> infection include immunodeficiency, prolonged hospitalization in the intensive care unit (ICU), prolonged mechanical ventilation, and the use of broad-spectrum antibiotics. Notably, a considerable proportion of cases (17\/63) are hospital-acquired.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>Elizabethkingia miricola<\/jats:italic> represents a rare but highly lethal opportunistic pathogen. Early identification and treatment with sensitive antibiotics are required to improve the prognosis of patients. The present case and literature review provide options for the diagnosis and treatment of similar cases in the future and serve as a reference for preventing and controlling the occurrence and spread of nosocomial infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic review registration<\/jats:title><jats:p><jats:uri>https:\/\/pubmed.ncbi.nlm.nih.gov\/<\/jats:uri>, <jats:uri>https:\/\/www.webofscience.com\/wos\/<\/jats:uri>.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1561379","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T17:22:03Z","timestamp":1746638523000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Septic shock caused by Elizabethkingia miricola in an elderly trauma patient: a case report and systematic literature review"],"prefix":"10.3389","volume":"12","author":[{"given":"Xiaoxiao","family":"Mao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiupeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqing","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1078\/072320203770865828","article-title":"Chryseobacterium miricola sp. nov., a novel species isolated from condensation water of space station Mir","volume":"26","author":"Li","year":"2003","journal-title":"Syst Appl Microbiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.diagmicrobio.2008.07.015","article-title":"Sepsis caused by Elizabethkingia miricola successfully treated with tigecycline and levofloxacin","volume":"62","author":"Green","year":"2008","journal-title":"Diagn Microbiol Infect Dis"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.diagmicrobio.2018.11.025","article-title":"Elizabethkingia miricola: discrepancies in identification and antimicrobial susceptibilities","volume":"94","author":"Rahim","year":"2019","journal-title":"Diagn Microbiol Infect Dis"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.ijantimicag.2016.09.031","article-title":"Genome of the carbapenemase-producing clinical isolate Elizabethkingia miricola EM_CHUV and comparative genomics with Elizabethkingia meningoseptica and Elizabethkingia anophelis: evidence for intrinsic multidrug resistance trait of emerging pathogens","volume":"49","author":"Opota","year":"2017","journal-title":"Int J Antimicrob Agents"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1128\/JCM.01637-16","article-title":"Relative prevalence and antimicrobial susceptibility of clinical isolates of Elizabethkingia species based on 16S rRNA gene sequencing","volume":"55","author":"Han","year":"2016","journal-title":"J Clin Microbiol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"187","DOI":"10.12998\/wjcc.v5.i5.187","article-title":"Elizabethkingia miricola: a rare non-fermenter causing urinary tract infection","volume":"5","author":"Gupta","year":"2017","journal-title":"World J Clin Cases"},{"volume-title":"Performance standards for antimicrobial susceptibility 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