{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:00:14Z","timestamp":1792688414637,"version":"4.5.0"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To explore the clinical anesthesia effect of different doses of fospropofol disodium for painless colonoscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>\n                      A total of 69 patients undergoing colonoscopy under general intravenous anesthesia were included in this study. They were divided into three groups: fospropofol disodium 10\u202fmg\/kg group (P1 group,\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f23), fospropofol disodium 12.5\u202fmg\/kg group (P2 group,\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f23), and fospropofol disodium 15\u202fmg\/kg group (P3 group,\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f23). All patients were first injected with 5\u202f\u03bcg\/kg of alfentanil intravenously at the time of anesthesia induction, 1\u202fmin later, group P1, group P2 and group P3 were given 10\u202fmg\/kg, 12.5\u202fmg\/kg and 15\u202fmg\/kg of fospropofol disodium, respectively. The success rate of the first sedation, the time of sedation start, the time of awakening, hemodynamic changes and adverse reactions were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The success rate of first sedation in the P2 and P3 groups was significantly higher than that in the P1 group (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). The onset time of sedation was significantly shorter in the P2 and P3 groups than in the P1 group (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). The awakening time of the P2 group and the P3 group (9\u202fmin vs. 7\u202fmin) was significantly longer than that of the P1 group (5\u202fmin) (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). The incidence of hypotension in the P3 group was significantly higher than that in the P1 and P2 groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). At T2, the MAP of the P3 group decreased significantly compared with the P1 and P2 groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). There were no significant differences in adverse reactions such as injection pain, abnormal sensation\/itching between the three groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;gt;\u202f0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In painless colonoscopy, fospropofol disodium 12.5\u202fmg\/kg combined with alfentanil 5\u202f\u03bcg\/kg has a high success rate of first-time sedation and low hemodynamic impact, which has some clinical advantages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>ChiCTR2400090788.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1562592","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T03:08:19Z","timestamp":1741921699000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Anesthesia effects of different doses of fospropofol disodium for painless colonoscopy diagnosis and 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