{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:50:25Z","timestamp":1793299825335,"version":"4.5.0"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Gastric cancer is still an important public health problem. Efforts have been made to lower its prevalence globally. The Operative Link on Gastritis Assessment (OLGA) and operating link for gastric intestinal metaplasia (OLGIM) histological grading systems have been proposed to identify individuals with types of gastritis that have the potential to become malignant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim of the study<\/jats:title><jats:p>Our study was conducted to assess the value of OLGA and OLGIM systems in the diagnosis of gastric precancerous lesions, in the Moldovan population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective study, 142 consecutive patients with chronic atrophic gastritis (CAG) from a larger group of patients referred to upper gastrointestinal endoscopy for dyspeptic symptoms or gastric cancer screening was investigated. The sample was divided into three groups: (a) CAG without intestinal metaplasia and gastric dysplasia; (b) CAG with intestinal metaplasia; (c) CAG with gastric dysplasia according to the morphological type of the lesion. GastroPanel biomarkers were correlated with OLGA and OLGIM stages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a direct, moderate and statistically significant correlation between types of CAG and OLGA stages (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001), a direct, weak and statistically significant correlation between forms of chronic atrophic gastritis and OLGIM stages (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001). A statistically significant reduction in Pepsinogen I and the Pepsinogen-I\/Pepsinogen-II ratio was observed alongside an increase in the stages of the OLGA and OLGIM systems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OLGA and OLGIM systems are useful tools in diagnosing CAG. This is the first study assessing the use of this systems in the Moldovan population.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1563889","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T07:05:27Z","timestamp":1742281527000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Assessing gastric cancer risk using the OLGA and OLGIM systems in Republic of Moldova"],"prefix":"10.3389","volume":"12","author":[{"given":"Adriana","family":"Botezatu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu-Alexandru","family":"Farcas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Grad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-Lucian","family":"Dumitra\u0219cu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolae","family":"Bodrug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Rugge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1136\/gut.2006.106666","article-title":"Gastritis staging in clinical practice: the OLGA staging system","volume":"56","author":"Rugge","year":"2007","journal-title":"Gut"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1055\/a-0996-0912","article-title":"Curriculum for endoscopic submucosal dissection training in Europe: European Society of Gastrointestinal Endoscopy (ESGE) position statement","volume":"51","author":"Pimentel-Nunes","year":"2019","journal-title":"Endoscopy"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.15386\/mpr-1887","article-title":"Chronic atrophic gastritis: an update on diagnosis","volume":"94","author":"Botezatu","year":"2021","journal-title":"Med Pharm Rep"},{"key":"ref4","first-page":"49","article-title":"Valoarea diagnostic\u0103 \u0219i prognostic\u0103 a clasific\u0103rii \u201cOLGA\u201d a gastritelor cronice","volume":"13","author":"Piciu","year":"2016","journal-title":"Med Intern"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1016\/j.dld.2019.09.016","article-title":"Chronic atrophic gastritis: natural history, diagnosis and therapeutic management. 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'OLGA\/OLGIM' and serum pepsinogen test in assessment of gastric atrophy\/intestinal metaplasia in China","volume":"52","author":"Wang","year":"2017","journal-title":"Scand J Gastroenterol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1097\/MEG.0b013e3283438ac3","article-title":"Gastric plasma biomarkers and operative link for gastritis assessment gastritis stage","volume":"23","author":"Daugule","year":"2011","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1097\/MEG.0000000000001015","article-title":"Gastritis staging as a clinical priority","volume":"30","author":"Mescoli","year":"2018","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"e18","DOI":"10.1136\/gutjnl-2023-331059","article-title":"Comparison of OLGA and OLGIM as predictors of gastric cancer in a Latin American population: the ECHOS study","volume":"73","author":"Latorre","year":"2023","journal-title":"Gut"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1080\/00365521.2020.1740777","article-title":"Use of endoscopic assessment of gastric atrophy for gastric cancer risk stratification to reduce the need for gastric mapping","volume":"55","author":"Quach","year":"2020","journal-title":"Scand J Gastroenterol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/j.1440-1746.2010.06474.x","article-title":"The severity of endoscopic gastric atrophy could help to predict operative link on gastritis assessment gastritis stage","volume":"26","author":"Quach","year":"2011","journal-title":"J Gastroenterol Hepatol"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1563889\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T07:05:30Z","timestamp":1742281530000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1563889\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,18]]},"references-count":28,"alternative-id":["10.3389\/fmed.2025.1563889"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1563889","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,18]]},"article-number":"1563889"}}