{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:06:08Z","timestamp":1782399968257,"version":"3.54.5"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Patient-level ultrasound joint inflammation outcomes, derived from the European Alliance of Associations for Rheumatology-Outcome Measures in Rheumatology (EULAR-OMERACT) joint-level scoring of elementary components and the combined score (CS), were compared with measures of disease activity and joint damage in patients with rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical joint assessment and a 22-joint (bilateral hands\/wrists) ultrasonography were performed independently during the same patient study visit. Patient-level ultrasound joint inflammation outcomes [total power Doppler (PD) score, total grayscale (GS) score, total CS, number of joint(s) with CS\u202f\u2265\u202f2 (at least moderate synovitis), and number of joint(s) with ultrasound synovitis defined as PD\u202f&amp;gt;\u202f0 or GS\u202f\u2265\u202f2] derived from the EULAR-OMERACT joint-level scoring system were correlated with Clinical Disease Activity Index (CDAI), 28-joint disease activity score (DAS28), and ultrasound-detected joint damage, i.e., total bone erosion score (TBES). The relationship between the variables was studied using simple linear regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 83 RA patients underwent scanning of 1,826 joints in this cross-sectional study. All patient-level ultrasound joint inflammation outcomes showed significant correlations (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.01) with CDAI, DAS28, and TBES (with correlation coefficients ranging from 0.45 to 0.48, 0.38 to 0.45, and 0.66 to 0.83, respectively). A linear regression analysis revealed statistically significant relationships (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.01) for all patient-level ultrasound joint inflammation outcomes in relation to CDAI, DAS28, and TBES (with regression coefficients ranging from 0.603 to 1.260, 0.066 to 0.149, and 0.416 to 0.818, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patient-level ultrasound joint inflammation outcomes, derived from the EULAR-OMERACT joint-level scoring system, showed good construct validity when compared to both disease activity and joint damage in patients with RA.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1564381","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T04:10:59Z","timestamp":1747282259000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["The EULAR-OMERACT joint-level scoring of ultrasound synovitis demonstrates good construct validity when tested at the patient-level in comparison with measures of disease activity and joint damage in patients with rheumatoid arthritis"],"prefix":"10.3389","volume":"12","author":[{"given":"York Kiat","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Thumboo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s11926-020-00911-w","article-title":"The role of musculoskeletal Ultrasound in the rheumatoid arthritis continuum","volume":"22","author":"Di Matteo","year":"2020","journal-title":"Curr Rheumatol Rep"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1756-185X.2011.01677.x","article-title":"Insights into osteoarthritis from 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