{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T15:07:47Z","timestamp":1776438467077,"version":"3.51.2"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by chronic infection with human papillomavirus (HPV), leading to disseminated flat-topped papules and pityriasis versicolor-like lesions. Patients with EV are predisposed to developing non-melanoma skin cancers, particularly squamous cell carcinoma (SCC) in sun-exposed areas. Currently, there is no definitive cure for EV, and management remains largely supportive and symptomatic. We report a case of EV in a 38-year-old male, presenting with classical clinical features and histopathological findings, complicated by the simultaneous development of squamous cell carcinoma(SCC) and basal cell carcinoma (BCC). This case highlights the oncogenic potential of EV-associated HPV subtypes and the importance of regular dermatologic surveillance in affected individuals.<\/jats:p>","DOI":"10.3389\/fmed.2025.1565977","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:14:37Z","timestamp":1748996077000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Epidermodysplasia verruciformis with multiple squamous and basal cell carcinomas"],"prefix":"10.3389","volume":"12","author":[{"given":"Zijing","family":"Zhang","sequence":"first","affiliation":[{"name":"The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou First People's Hospital","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanbo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Plastic and Cosmetic Surgery, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University","place":["Hangzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinsheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Plastic and Cosmetic Surgery, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University","place":["Hangzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/s0001-4079(19)32253-8","article-title":"Genetics and susceptibility to human papillomaviruses: epidermodysplasia verruciformis, a disease model","volume":"194","author":"Orth","year":"2010","journal-title":"Bull Acad Natl Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"18s","DOI":"10.1111\/1523-1747.ep12281128","article-title":"Clinical observations, virologic studies, and treatment trials in patients with epidermodysplasia verruciformis, a disease induced by specific human papillomaviruses","volume":"83","author":"Lutzner","year":"1984","journal-title":"J Invest Dermatol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.smim.2006.07.008","article-title":"Genetics of epidermodysplasia verruciformis: insights into host defense against papillomaviruses","volume":"18","author":"Orth","year":"2006","journal-title":"Semin Immunol"},{"key":"B4","first-page":"169","article-title":"Epidermodysplasia verruciformis. 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