{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:49:12Z","timestamp":1790668152041,"version":"4.1.0"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify independent risk factors and predictive markers for acute pancreatitis (AP) in patients with diabetic ketoacidosis (DKA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Here, we reported a 11-year experience in a single tertiary medical center and conduct a systematic review of acute pancreatitis in diabetic ketoacidosis patients (DKA-AP). 1,941 cases were included. First retrospective cohort study analyzed clinical data from 45 patients with DKA-AP and 45 matched controls with DKA alone (DKA-nonAP) admitted to Yangzhou University Affiliated Hospital (2013\u20132024). Baseline characteristics included BMI, hyperlipidemia history, and serological profiles. Secondly we retrieved clinical studies of DKA-AP from PubMed database system and analyzed these clinical data in depth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant differences were observed in BMI: median [IQR]\u202f=\u202f26.30 [22.15\u201328.40] vs. 23.20 [20.70\u201325.35] kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.031, hyperlipidemia history (26.7% vs. 4.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.004), abdominal pain duration (3 vs. 0\u202fdays,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), and lipid profiles TC: median [IQR]\u202f=\u202f7.71 [5.60\u201311.66] vs. 4.86 [4.22\u20136.52] mmol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001; TG: median [IQR]\u202f=\u202f11.90 [4.71\u201315.84] vs. 1.60 [0.89\u20133.64] mmol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001. Logistic regression identified TC (OR\u202f=\u202f1.455, 95% CI: 1.196\u20131.769), TG (OR\u202f=\u202f2.046, 95% CI: 1.202\u20133.484), and abdominal pain duration (OR\u202f=\u202f3.892, 95% CI: 2.173\u20136.972) as independent risk factors. Receiver operating characteristic curve (ROC) analysis demonstrated strong predictive performance (combined AUC\u202f=\u202f0.933, sensitivity\u202f=\u202f93.3%, specificity\u202f=\u202f73.3%). Moreover, we found 11 clinical studies investigating DKA-AP. Cumulatively, 1,851 patients were studied, including 3 interventional studies, 1 genetic observational study, and 7 cohort studies exploring risk factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated TC, TG, and prolonged abdominal pain duration are key predictors of DKA-AP. These factors enhance early diagnosis and clinical management in Yangzhou, China.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1571631","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T01:18:57Z","timestamp":1743988737000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Risk factors associated with acute pancreatitis in diabetic ketoacidosis patients: a 11-year experience in a single tertiary medical center and comprehensive literature review"],"prefix":"10.3389","volume":"12","author":[{"given":"Yifei","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Bo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuanzhuan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2795","DOI":"10.1111\/j.1572-0241.2000.03188.x","article-title":"Association of diabetic ketoacidosis and acute pancreatitis: observations in 100 consecutive episodes of DKA","volume":"95","author":"Nair","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e14378","DOI":"10.1097\/MD.0000000000014378","article-title":"The triad of diabetes ketoacidosis, hypertriglyceridemia and acute pancreatitis. 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