{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:06:25Z","timestamp":1753891585845,"version":"3.41.2"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>This open-label study evaluated the effects of a novel fiber supplement product, Relievance, on bowel movement regularity and symptoms of bloating and gas in 20 consecutive patients. The product is a commercially available combination of 8 natural fibers and the recommended dosage is approximately 6 grams per serving.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants, presenting with chronic bothersome gastrointestinal symptoms of bloating, gas or bowel irregularity were recruited from an outpatient primary care practice for the study. Participants consumed 6 g of the fiber blend (one heaping teaspoon), one to three times per day, over 6\u202fweeks, and kept diaries on symptoms and number of bowel movements per week. Symptoms were assessed via a 6-point analog scale at baseline and at 6\u202fweeks. Primary endpoints included changes in bowel movement frequency and symptom severity related to gas and bloating.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, participants averaged 1.7 bowel movements per week, which significantly increased to 3.2 per week by the study\u2019s conclusion. Symptom severity scores for bloating and gas also improved significantly, decreasing from 3.0 at baseline to 1.5 after 6\u202fweeks. These results demonstrated statistically significant improvements in both bowel regularity and symptom relief. No significant adverse events were reported during the study, highlighting the product\u2019s safety profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This small, non-randomized prospective trial suggests that Relievance, a proprietary blend of eight different fibers, may effectively enhance bowel movement frequency and alleviate symptoms of bloating and gas. Further randomized controlled trials are warranted to confirm these findings and explore broader applications.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1572261","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T12:37:29Z","timestamp":1743079049000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Open label study of a novel fiber product for bloating, gas, and bowel regularity"],"prefix":"10.3389","volume":"12","author":[{"given":"Alexander S.","family":"Ganz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brooke","family":"Greeley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Riggen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aundria","family":"Riggen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.3390\/nu5041417","article-title":"Fiber and prebiotics: mechanisms and health benefits","volume":"5","author":"Slavin","year":"2013","journal-title":"Nutrients"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1111\/j.1753-4887.2009.00189.x","article-title":"Health benefits of dietary fiber","volume":"67","author":"Anderson","year":"2009","journal-title":"Nutr Rev"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.3945\/jn.116.235358","article-title":"Gut microbiota richness and composition and dietary intake of overweight pregnant women are related to serum zonulin concentration, an index of intestinal permeability","volume":"146","author":"Mokkala","year":"2016","journal-title":"J Nutr"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/S0140-6736(18)31809-9","article-title":"Carbohydrate quality and human health: a series of systematic reviews and meta-analyses","volume":"393","author":"Reynolds","year":"2019","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.jand.2016.09.021","article-title":"Understanding the physics of functional fibers in the gastrointestinal tract: an evidence-based approach to resolving enduring misconceptions about insoluble and soluble fiber","volume":"117","author":"McRorie","year":"2017","journal-title":"J Acad Nutr Diet"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1093\/annonc\/mdr589","article-title":"Dietary fiber and breast cancer risk: a systematic review and meta-analysis of prospective studies","volume":"23","author":"Aune","year":"2011","journal-title":"Ann Oncol"},{"key":"ref7","first-page":"41","article-title":"The role of dietary fiber in colon cancer prevention: separating fact from fiction","volume":"4","author":"Kumar","year":"2012","journal-title":"World J Gastrointestinal Oncol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","article-title":"The international scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. 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