{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:46:17Z","timestamp":1791625577688,"version":"4.3.4"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Despite the widespread use of lung-protective ventilation in general anesthesia, the optimal positive end-expiratory pressure (PEEP) remains uncertain. This study aimed to investigate the effects of driving pressure-guided individualized PEEP in patients undergoing robot-assisted laparoscopic radical prostatectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty-two male patients undergoing robot-assisted laparoscopic radical prostatectomy were randomized to receive conventional fixed PEEP of 5 cmH<jats:sub>2<\/jats:sub>O (<jats:italic>n<\/jats:italic>\u202f=\u202f21, PEEP<jats:sub>5<\/jats:sub>) or driving pressure-guided individualized PEEP (<jats:italic>n<\/jats:italic>\u202f=\u202f21, PEEP<jats:sub>IND<\/jats:sub>). The primary outcome was the ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub>). The secondary outcomes included respiratory mechanics, hemodynamics, optic nerve sheath diameter (ONSD), and the incidence of postoperative delirium (POD) and postoperative pulmonary complications (PPCs) within a 7-day period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In comparison with the PEEP<jats:sub>5<\/jats:sub> group, the PEEP<jats:sub>IND<\/jats:sub> group showed significantly higher (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001) PEEP values during pneumoperitoneum in the Trendelenburg position (mean [standard deviation], 11.29 cmH<jats:sub>2<\/jats:sub>O [1.01 cmH<jats:sub>2<\/jats:sub>O]) and after deflation and repositioning to the supine position (mean [standard deviation], 7.05 cmH<jats:sub>2<\/jats:sub>O [1.20 cmH<jats:sub>2<\/jats:sub>O]). The PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> values in the PEEP<jats:sub>IND<\/jats:sub> group were significantly higher than those in the PEEP<jats:sub>5<\/jats:sub> group 120\u202fmin after pneumoperitoneum in the Trendelenburg position (<jats:italic>p<\/jats:italic>\u202f=\u202f0.023) and at the end of the operation (<jats:italic>p<\/jats:italic>\u202f=\u202f0.028). The groups showed no differences in ONSD, hemodynamics, and incidence of POD and PPCs (<jats:italic>p<\/jats:italic>\u202f&amp;gt;\u202f0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In comparison with a fixed PEEP of 5 cmH<jats:sub>2<\/jats:sub>O, driving pressure-guided individualized PEEP improves intraoperative respiratory mechanics and oxygenation without causing deterioration in hemodynamics, further escalation in intracranial pressure, or an increase in the incidence of POD. Nevertheless, this procedure requires meticulous monitoring. Unfortunately, individualized PEEP did not result in a reduction in the incidence of PPCs in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trial Registration<\/jats:title><jats:p><jats:uri>http:\/\/www.chictr.org.cn<\/jats:uri>, ChiCTR2400081338.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1573150","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T04:10:20Z","timestamp":1745295020000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Individualized positive end-expiratory pressure guided by driving pressure in robot-assisted laparoscopic radical prostatectomy: a prospective, randomized controlled clinical trial"],"prefix":"10.3389","volume":"12","author":[{"given":"Yanfang","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1097\/JS9.0000000000000193","article-title":"Robotic 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guided by electrical impedance tomography for robot-assisted laparoscopic radical prostatectomy: a prospective, randomised controlled clinical trial","volume":"125","author":"Girrbach","year":"2020","journal-title":"Br J Anaesth"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1097\/EJA.0000000000001901","article-title":"Individualised positive end-expiratory pressure titrated intra-operatively by electrical impedance tomography optimises pulmonary mechanics and reduces postoperative atelectasis: a randomised controlled trial","volume":"40","author":"Ma","year":"2023","journal-title":"Eur J Anaesthesiol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1093\/bja\/aew188","article-title":"Perioperative assessment of regional ventilation during changing body positions and ventilation conditions by electrical impedance tomography","volume":"117","author":"Ukere","year":"2016","journal-title":"Br J 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