{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:16:56Z","timestamp":1791505016516,"version":"4.3.4"},"reference-count":91,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The pathogenesis of neurodegenerative diseases is complex, involving multiple factors, including genetic, environmental, and lifestyle elements. Recent studies have suggested that infectious agents may act as important triggers for neurodegenerative diseases. This study aimed to evaluate the association between <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) infection and the risk of neurodegenerative disorders through a systematic review and meta-analysis of existing literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search was conducted across the PubMed, Embase, and Cochrane Library databases for studies published up to December 2024. The combined effect sizes were expressed as odds ratios (OR) with 95% confidence intervals (CI) and were calculated using a random-effects model. Further exploratory analyses included sensitivity analyses, subgroup analyses, and assessment of publication bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty-one studies involving 159,220 participants were selected for the meta-analysis. We found that <jats:italic>H. pylori<\/jats:italic> infection was associated with an increased risk of Parkinson\u2019s disease (OR: 1.70; 95% CI: 1.36\u20132.13; <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001), all-cause dementia (OR: 1.56; 95% CI: 1.24\u20131.96; <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001), and Alzheimer\u2019s disease (OR: 1.43; 95% CI: 1.01\u20132.02; <jats:italic>p<\/jats:italic>\u202f=\u202f0.045). However, <jats:italic>H. pylori<\/jats:italic> infection was not associated with the risk of multiple sclerosis (OR: 0.81; 95% CI: 0.59\u20131.11; <jats:italic>p<\/jats:italic>\u202f=\u202f0.193). Sensitivity analysis suggested that <jats:italic>H. pylori<\/jats:italic> infection might play a protective role in the subsequent risk of multiple sclerosis. Subgroup analyses indicated that the association between <jats:italic>H. pylori<\/jats:italic> infection and neurodegenerative disorders may vary based on country, study design, <jats:italic>H. pylori<\/jats:italic> detection technique, and study quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study found that <jats:italic>H. pylori<\/jats:italic> infection may be associated with an elevated risk of Parkinson\u2019s disease, all-cause dementia, and Alzheimer\u2019s disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic review registration<\/jats:title><jats:p>INPLASY (INPLASY202510044).<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1573299","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T05:28:15Z","timestamp":1751606895000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of Helicobacter pylori infection with the risk of neurodegenerative disorders: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"12","author":[{"given":"Jiwen","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiting","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenting","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongyao","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"6367","DOI":"10.1097\/JS9.0000000000001609","article-title":"Recent advances in stem cell therapy: efficacy, ethics, safety concerns, and future directions focusing on neurodegenerative disorders - a review","volume":"110","author":"Khandia","year":"2024","journal-title":"Int J Surg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S2468-1253(19)30333-4","article-title":"The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990-2017: a systematic analysis for the global burden of disease study 2017","volume":"5","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref3","article-title":"The global impact of dementia: an analysis of prevalence, incidence, cost and trends. 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