{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T01:28:13Z","timestamp":1755221293064,"version":"3.43.0"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>A 29-year-old woman with muscle weakness at 26\u202f+\u202f5\u202fweeks of pregnancy was hospitalized for heart failure, and genetic testing revealed that she had R9 limb-girdle muscular dystrophy (LGMDR9). Since LGMDR9 is associated with cardiac and respiratory dysfunction, we promoted fetal lung maturation and performed an emergency cesarean section at 29\u202f+\u202f2\u202fweeks to prevent further deterioration of cardiac function and muscle weakness. This case highlights the importance of choosing the right mode of delivery, timing of delivery, and early genetic testing for LGMDR9 patients.<\/jats:p>","DOI":"10.3389\/fmed.2025.1576161","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T14:21:47Z","timestamp":1754662907000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful perinatal management in pregnant women with R9 limb-girdle muscular dystrophy and left ventricular ejection fraction of 27%: a case report"],"prefix":"10.3389","volume":"12","author":[{"given":"Wenchi","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lok Chong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Landan","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koubihan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Mei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.jacc.2016.05.048","article-title":"High-risk cardiac disease in pregnancy: part I","volume":"68","author":"Elkayam","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"681","DOI":"10.2169\/internalmedicine.1673-23","article-title":"Successful Management of a Pregnant Patient with Danon cardiomyopathy","volume":"63","author":"Inoue","year":"2024","journal-title":"Intern Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/3710814","article-title":"Magnetic resonance imaging findings in the muscle tissue of patients with limb girdle muscular dystrophy type 2I harboring the founder mutation c.545A>G in the FKRP gene","volume":"2018","author":"Xie","year":"2018","journal-title":"Biomed Res Int"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.nmd.2016.08.012","article-title":"216th ENMC international workshop: clinical readiness in FKRP related myopathies January 15\u201317, 2016 Naarden, the Netherlands","volume":"26","author":"Richard","year":"2016","journal-title":"Neuromuscul Disord"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"615","DOI":"10.3233\/jnd-221618","article-title":"Phenotype genotype characterization of FKRP-related muscular dystrophy among Indian patients","volume":"10","author":"Unnikrishnan","year":"2023","journal-title":"J Neuromuscul Dis"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1177\/1753495x18814622","article-title":"Obstetric management of a woman with limb-girdle muscular dystrophy type 2I and dilated cardiomyopathy","volume":"12","author":"von Guionneau","year":"2018","journal-title":"Obstet Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1002\/mus.27052","article-title":"Cardiomyopathy in limb girdle muscular dystrophy R9, FKRP related","volume":"62","author":"Libell","year":"2020","journal-title":"Muscle Nerve"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1002\/mus.27184","article-title":"The outcomes and experience of pregnancy in limb girdle muscular dystrophy type R9","volume":"63","author":"Libell","year":"2021","journal-title":"Muscle Nerve"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1258\/om.2010.090052","article-title":"Normal vaginal delivery in a patient with autosomal recessive limb-girdle muscular dystrophy","volume":"3","author":"Black","year":"2010","journal-title":"Obstet Med"},{"key":"ref10","first-page":"243","article-title":"Pregnancy and delivery in Leyden-M\u00f6bius muscular dystrophy. Case report","volume":"36","author":"Vavrinkova","year":"2015","journal-title":"Neuro Endocrinol Lett"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1051\/medsci\/2020239","article-title":"La dystrophie musculaire des ceintures de type R9 li\u00e9e au g\u00e8ne FKRP","volume":"36","author":"Villar Quiles","year":"2021","journal-title":"Med Sci"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"3165","DOI":"10.1093\/eurheartj\/ehy340","article-title":"2018 ESC guidelines for the management of cardiovascular diseases during pregnancy","volume":"39","author":"Regitz-Zagrosek","year":"2018","journal-title":"Eur Heart J"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.ijoa.2007.03.003","article-title":"Anaesthetic management of a woman with autosomal recessive limb-girdle muscular dystrophy for emergency caesarean section","volume":"16","author":"Allen","year":"2007","journal-title":"Int J Obstet Anesth"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.jacc.2016.05.050","article-title":"High-risk cardiac disease in pregnancy: part II","volume":"68","author":"Elkayam","year":"2016","journal-title":"J Am Coll Cardiol"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1576161\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T14:21:48Z","timestamp":1754662908000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1576161\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,8]]},"references-count":14,"alternative-id":["10.3389\/fmed.2025.1576161"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1576161","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,8]]},"article-number":"1576161"}}