{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:46:18Z","timestamp":1791182778499,"version":"4.1.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Dysmenorrhea symptoms are frequent and often self-treated using non-prescription medicines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To further characterize women with dysmenorrhea using a combination of hyoscine butylbromide plus paracetamol (PLUS) for self-management of their complaints, we performed a secondary analysis of a published pharmacy-based patient survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 314 women (mean age: 32.3\u202fyears) with dysmenorrhea reported a pain and cramps intensity of 7.45\u202f\u00b1\u202f2.13 (means \u00b1 SD) on a 0\u201310 Likert scale, which was reduced to 2.86\u202f\u00b1\u202f1.81 upon treatment. Associated impairments of work\/daily chores, leisure activities, and sleep were improved by 64.6, 62.2, and 70.4%, respectively. The onset of symptom relief was within 60\u202fmin in 84.7%. Tolerability was rated as very good or good by 97.2%; 82.8% were repeat users, 97.5% reported their intention to purchase the product again, and 97.1% reported their intention to recommend it to relatives, friends, and colleagues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These findings confirm the efficacy and tolerability data on PLUS from randomized controlled trials in a larger group of women conducting self-management of their dysmenorrhea in a real-world setting. Future studies should compare PLUS to other non-prescription treatments.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1581059","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T15:58:16Z","timestamp":1744732696000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Real-world effects of hyoscine butylbromide combined with paracetamol in women with dysmenorrhea: a patient survey"],"prefix":"10.3389","volume":"12","author":[{"given":"Kathrin","family":"Stewen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina","family":"Miehle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Weigmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1093\/epirev\/mxt009","article-title":"The prevalence and risk factors of dysmenorrhea","volume":"36","author":"Ju","year":"2014","journal-title":"Epidemiol Rev"},{"key":"ref2","first-page":"341","article-title":"Diagnosis and initial management of dysmenorrhea","volume":"89","author":"Osayande","year":"2014","journal-title":"Am Fam Physician"},{"key":"ref3","first-page":"164","article-title":"Dysmenorrhea","volume":"104","author":"McKenna","year":"2021","journal-title":"Am Fam Physician"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1097\/AOG.0000000000004096","article-title":"Primary dysmenorrhea: diagnosis and therapy","volume":"136","author":"Ferries-Rowe","year":"2020","journal-title":"Obstet Gynecol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"169","DOI":"10.2147\/JPR.S30602","article-title":"Prevalence of menstrual pain in young women: what is dysmenorrhea?","volume":"5","author":"Grandi","year":"2012","journal-title":"J Pain Res"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e0256433","DOI":"10.1371\/journal.pone.0256433","article-title":"Pain experience and social support of endometriosis patients during the COVID-19 pandemic in Germany - 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