{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T18:45:48Z","timestamp":1781808348405,"version":"3.54.5"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This is the first comprehensive comparison between gonioscopy-assisted transluminal trabeculotomy (GATT) and GATT combined with ab interno canaloplasty (ABiC) in patients with OAG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of this study was to compare the efficacy and safety of gonioscopy-assisted transluminal trabeculotomy (GATT) combined with ab interno canaloplasty (ABiC) with those of GATT alone in patients with open-angle glaucoma (OAG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This was a retrospective, comparative case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Patients with primary open angle glaucoma who underwent GATT (27 eyes in Group 1) or GATT + ABiC (26 eyes in Group 2) were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Outcomes including intraocular pressure (IOP), glaucoma medications, and surgical complications were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Surgical success was defined in terms of IOP and medication use as follows: (1) a preoperative IOP\u202f&amp;gt;\u202f21\u202fmmHg and a postoperative IOP\u202f\u2264\u202f21\u202fmmHg with at least a 20% reduction from baseline with (qualified success) or without (complete success) glaucoma medications or (2) a preoperative IOP\u202f&amp;lt;\u202f21\u202fmmHg while taking 3 or more glaucoma medications and a postoperative IOP\u202f\u2264\u202f21\u202fmmHg with a reduction of more than two medications (qualified success) or with no medications (complete success).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 12\u202fmonths, the mean IOP was 14.8\u202f\u00b1\u202f2.2\u202fmmHg in Group 1 and 16.6\u202f\u00b1\u202f2.3\u202fmmHg in Group 2 (<jats:italic>p<\/jats:italic>\u202f=\u202f0.008). The number of medications was 0.6\u202f\u00b1\u202f1.0 in Group 1 and 0.9\u202f\u00b1\u202f1.3 in Group 2 (<jats:italic>p<\/jats:italic>\u202f=\u202f0.334). At 24\u202fmonths, the mean IOP was 15.3\u202f\u00b1\u202f2.0\u202fmmHg in Group 1 and 15.5\u202f\u00b1\u202f2.4\u202fmmHg in Group 2 (<jats:italic>p<\/jats:italic>\u202f=\u202f0.676). The number of medications was 0.5\u202f\u00b1\u202f0.9 in Group 1 and 0.9\u202f\u00b1\u202f1.1 in Group 2 (<jats:italic>p<\/jats:italic>\u202f=\u202f0.197). The complete success rates were 63.0% in Group 1 and 50.0% in Group 2 (<jats:italic>p<\/jats:italic>\u202f=\u202f0.16), and the qualified success rates were 81.5% in Group 1 and 76.9% in Group 2 (<jats:italic>p<\/jats:italic>\u202f=\u202f0.51).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The GATT procedure, with or without ABiC, is safe and effective in decreasing the IOP and the number of antiglaucoma medications used.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1581608","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T13:30:48Z","timestamp":1756215048000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparative effectiveness and safety of GATT with or without ABiC in patients with open-angle 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