{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T02:22:52Z","timestamp":1777083772222,"version":"3.51.4"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy with a poor prognosis. The value of 2-[<jats:sup>18<\/jats:sup>F]fluoro-2-deoxy-D-glucose positron emission tomography\/computed tomography (<jats:sup>18<\/jats:sup>F-FDG PET\/CT) in BPDCN has not been clarified. This study aimed to investigate the imaging findings of <jats:sup>18<\/jats:sup>F-FDG PET\/CT in patients with BPDCN based on cases from our institution and the literature. The clinical and radiological data were obtained from five patients with BPDCN from our institution between March 2014 and July 2023. Additionally, we complemented our dataset with 13 cases derived from the studies published in English to ascertain the potential efficacy of <jats:sup>18<\/jats:sup>F-FDG PET\/CT scan in identifying this malignancy. Information collected included age, sex, extent of lesion involvement, biopsy site, karyotype, immunophenotype, treatment, prognosis, and <jats:sup>18<\/jats:sup>F-FDG PET\/CT-features. A total of 18 cases of BPDCN featuring PET\/CT manifestations were assessed. We observed considerably increased <jats:sup>18<\/jats:sup>F-FDG uptake in lesions of all 18 cases [maximum standardized uptake value (SUV<jats:sub>max<\/jats:sub>), 9.1; range, 1.5\u20139.1]. The positive findings of <jats:sup>18<\/jats:sup>F-FDG PET\/CT mainly included skin (11\/18), lymph nodes (9\/18), bone (4\/18), and spleen (2\/18). Except for these organs, abnormal <jats:sup>18<\/jats:sup>F-FDG uptake lesions were detected in the lung and breast. The roles of <jats:sup>18<\/jats:sup>F-FDG PET\/CT in our study were initial staging (18\/18), selection of biopsy site (5\/18), and treatment evaluation (7\/18). Prognostic data were available in 16 patients. The median overall survival (OS) in this cohort was 12.0\u202fmonths, and the median follow-up time was 10.0\u202fmonths. Among these, 10 cases reported SUV<jats:sub>max<\/jats:sub> of lesions at the same time. Five out of eight patients with SUV<jats:sub>max<\/jats:sub>\u202f&amp;gt;\u202f2.5 died within 2\u202fmonths of diagnosis, whereas two other cases with SUV<jats:sub>max<\/jats:sub>\u202f&amp;lt;\u202f2.5 survived within 10 and 34\u202fmonths of follow-up. The data from our case series and those from the literature demonstrated the potential utility of <jats:sup>18<\/jats:sup>F-FDG PET\/CT in diagnosis, staging, prognosis, and treatment follow-up of BPDCN. Early identification of this rare malignancy on imaging can expedite diagnosis and facilitate early treatment.<\/jats:p>","DOI":"10.3389\/fmed.2025.1581760","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T05:31:39Z","timestamp":1758259899000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Imaging findings for 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography\/computed tomography in blastic plasmacytoid dendritic cell neoplasm: case series and literature review"],"prefix":"10.3389","volume":"12","author":[{"given":"Yujing","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyue","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lujie","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"3210","DOI":"10.1182\/blood.V97.10.3210","article-title":"Identification of a leukemic counterpart of the plasmacytoid dendritic cells","volume":"97","author":"Chaperot","year":"2001","journal-title":"Blood"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1182\/blood-2016-03-643544","article-title":"The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia","volume":"127","author":"Arber","year":"2016","journal-title":"Blood"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.clml.2019.06.002","article-title":"Blastic plasmacytoid dendritic cell neoplasm\u2013current insights","volume":"19","author":"Sangeetha","year":"2001","journal-title":"Clin Lymph Myeloma Leuk"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"4838","DOI":"10.1182\/bloodadvances.2020002474","article-title":"Blastic plasmacytoid dendritic cell neoplasms: results of an international survey on 398 adult patients","volume":"4","author":"Laribi","year":"2020","journal-title":"Blood Adv"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1186\/s13256-021-02939-7","article-title":"Venetoclax in relapsed\/refractory blastic plasmacytoid dendritic cell neoplasm with central nervous system involvement: a case report and review of the literature","volume":"15","author":"Albiol","year":"2021","journal-title":"J Med Case Rep"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1182\/blood.2022017308","article-title":"Blastic plasmacytoid dendritic cell neoplasm in ocular adnexa","volume":"140","author":"Zandi","year":"2022","journal-title":"Blood"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s00277-012-1557-4","article-title":"Lung involvement at initial presentation in blastic plasmacytoid dendritic cell neoplasm lacking cutaneous lesion","volume":"92","author":"Endo","year":"2013","journal-title":"Ann Hematol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1097\/md.0000000000025699","article-title":"Blastic plasmacytoid dendritic cell neoplasm of the breast a case report and review of the literature","volume":"100","author":"Lee","year":"2021","journal-title":"Medicine"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"27","DOI":"10.2298\/SARH191111027D","article-title":"Blastic plasmacytoid dendritic cell neoplasm of the uterus","volume":"148","author":"Djurdjevic","year":"2020","journal-title":"Srp Arh Celok Lek"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1148\/114.1.89","article-title":"A positron-emission transaxial tomograph for nuclear imaging (PETT)","volume":"114","author":"Ter-Pogossian","year":"1975","journal-title":"Radiology"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"5941","DOI":"10.3390\/cancers14235941","article-title":"Pet-ct in clinical adult oncology: I. 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