{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:17:57Z","timestamp":1755217077511,"version":"3.43.0"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the prevalence of childhood trauma, depression, and anxiety disorders between patients with early arthritis (EA) and a control group (CG). We further aimed to explore the influence of these variables on EA diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p>This monocentric study included 60 prospectively recruited EA patients with at least one inflammatory joint with a symptom duration of 1\u201312\u202fmonths. The CG consisted of 60 individuals with no clinical signs of arthritis. The participants underwent a semi-structured interview screening for psychiatric disorders and completed standardized questionnaires, including the Hospital Anxiety and Depression Scale (HADS-A, HADS-D), the Childhood Trauma Questionnaire (CTQ), and the Posttraumatic Diagnostic Scale (PDS). For statistical analysis, we used SPPS\u00a9 \u03c7<jats:sup>2<\/jats:sup> test, T-test, Mann\u2013Whitney U-test, and binominal regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the CG, patients with EA had significantly higher rates of depression in the interview (41.7% vs. 16.7%; <jats:italic>p<\/jats:italic> =\u202f0.03) and PTSD (13.3% vs. 3.3%; <jats:italic>p<\/jats:italic> =\u202f0.048), and significantly higher HADS-D and CTQ childhood sexual abuse mean scores (HADS-D: 5.40\u202f\u00b1\u202f4.80 vs. 3.60\u202f\u00b1\u202f3.30; <jats:italic>p<\/jats:italic> =\u202f0.047; CTQ sexual abuse: 5.91\u202f\u00b1\u202f2.68 vs. 5.15\u202f\u00b1\u202f1.02; <jats:italic>p<\/jats:italic> =\u202f0.042). Binomial regression analysis revealed higher odds ratios for EA for CTQ emotional neglect (<jats:italic>p<\/jats:italic> =\u202f0.048, OR\u202f=\u202f1.12), CTQ sexual abuse (<jats:italic>p<\/jats:italic> =\u202f0.040, OR\u202f=\u202f1.4), HADS-D (<jats:italic>p<\/jats:italic> =\u202f0.025, OR\u202f=\u202f1.12), and lifetime depression (<jats:italic>p<\/jats:italic> =\u202f0.040, OR\u202f=\u202f4.00).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The high rates of depression and PTSD in EA emphasize a potential link between psychiatric disorders and arthritis. The presence of EA might be associated with present and lifetime depressive symptoms, childhood sexual abuse and emotional neglect.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1582075","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T05:25:41Z","timestamp":1754371541000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations between childhood trauma, depression, anxiety disorders and early arthritis presence"],"prefix":"10.3389","volume":"12","author":[{"given":"Ana","family":"Konjikusic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Ohrndorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Braun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivien","family":"Kluckow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"H\u00f6hne-Zimmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Schmittat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Heim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Uebelhack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Minden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Detert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerd-R\u00fcdiger","family":"Burmester","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desiree","family":"Schaumburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/PSY.0000000000001025","article-title":"Childhood maltreatment and psychiatric comorbidity in immune-mediated inflammatory disorders","volume":"84","author":"Wan","year":"2022","journal-title":"Psychosom Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"18001","DOI":"10.1038\/nrdp.2018.1","article-title":"Rheumatoid arthritis","volume":"4","author":"Smolen","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e15373","DOI":"10.1097\/MD.0000000000015373","article-title":"Psychological affection in rheumatoid arthritis patients in relation to disease activity","volume":"98","author":"Hassan","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"ref4","first-page":"575","article-title":"The psychogenic problem (endocrinal and metabolic) in chronic arthritis","volume":"214","author":"Ha","year":"1936","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1176\/appi.psy.51.4.338","article-title":"Prevalence and determinants of psychiatric disorders in patients with rheumatoid arthritis","volume":"51","author":"Lok","year":"2010","journal-title":"Psychosomatics"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1002\/acr.23539","article-title":"Increased burden of psychiatric disorders in rheumatoid arthritis","volume":"70","author":"Marrie","year":"2018","journal-title":"Arthritis Care Res"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1007\/s00393-018-0571-x","article-title":"Higher prevalence of depressive and anxiety symptoms in early arthritis patients in comparison to the normal population","volume":"78","author":"Freier","year":"2019","journal-title":"Z Rheumatol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e001376","DOI":"10.1136\/rmdopen-2020-001376","article-title":"Depression and anxiety in an early rheumatoid arthritis inception cohort. 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Res"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1093\/rheumatology\/keu371","article-title":"Psychological distress over time in early rheumatoid arthritis: results from a longitudinal study in an early arthritis cohort","volume":"54","author":"Bacconnier","year":"2015","journal-title":"Rheumatology (Oxford)"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"126","DOI":"10.5152\/eurjrheum.2019.18184","article-title":"Effects of childhood psychological trauma on rheumatic diseases","volume":"6","author":"Salihoglu","year":"2019","journal-title":"Eur J Rheumatol"},{"key":"ref45","first-page":"575","article-title":"Self-reported childhood maltreatment, lifelong traumatic events and mental disorders in American and Israeli rheumatoid arthritis patients","volume":"36","author":"Merdler-Rabinowicz","year":"2018","journal-title":"Clin Exp Rheumatol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.jpsychores.2012.10.007","article-title":"Gender-specific association between childhood trauma and rheumatoid arthritis: a case-control study","volume":"74","author":"Spitzer","year":"2013","journal-title":"J Psychosom Res"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/3865249","article-title":"Self-reported childhood maltreatment and traumatic events among Israeli patients suffering from fibromyalgia and rheumatoid arthritis","volume":"2017","author":"Hellou","year":"2017","journal-title":"Pain Res Manag"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1002\/acr.21778","article-title":"Prospective study of posttraumatic stress disorder and disease activity outcomes in US veterans with rheumatoid arthritis","volume":"65","author":"Mikuls","year":"2013","journal-title":"Arthritis Care 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