{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T12:44:56Z","timestamp":1765370696027,"version":"3.41.2"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Stable vitiligo significantly impacts patients\u2019 quality of life and presents a considerable challenge to healthcare providers. In recent years, cell therapy has emerged as a promising treatment for stable vitiligo, which is demonstrated encouraging results. Among current cell-based therapies, autologous epidermal cell transplantation is regarded as a safe and cost-effective strategy. However, the therapeutic outcome critically depends on the retention and viability of the transplanted cells at the target site. Therefore, there is an urgent need to develop novel strategies to improve cell retention and maintain cell viability for improving therapeutic efficacy. In this work, a novel cell extraction method was first developed with deal with 2\u202fh at 37\u00b0C to obtain epidermal cells while maintaining high cell viability. Subsequently, the crosslinked hyaluronic acid (HA) by BDDE was utilized as 3D scaffold for cell delivery to treat stable vitiligo. By combining the new extraction method with the HA-based hydrogel scaffold, we achieved prolonged cell retention without compromising cell viability. This approach provides a promising, time-saving strategy for treating stable vitiligo using autologous epidermal cells.<\/jats:p>","DOI":"10.3389\/fmed.2025.1583271","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T04:13:21Z","timestamp":1747023201000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Injectable crosslinked HA hydrogel: a promising carrier for cell transplantation to treat stable vitiligo"],"prefix":"10.3389","volume":"12","author":[{"given":"Qianren","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weikai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiqin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youguo","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiulin","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunli","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"333","DOI":"10.5021\/ad.23.065","article-title":"Understanding of Pathomechanisms and clinical practice for vitiligo","volume":"35","author":"Tanemura","year":"2023","journal-title":"Ann Dermatol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s00403-025-03846-3","article-title":"Stable vitiligo treated by transplantation of autologous melanocytes: a meta-analysis","volume":"317","author":"Cao","year":"2025","journal-title":"Arch Dermatol Res"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1007\/s00403-025-03813-y","article-title":"Comparative study between combined follicular and epidermal cell suspension versus epidermal cell suspension in treatment of stable vitiligo","volume":"317","author":"Eleslam Shaker","year":"2025","journal-title":"Arch Dermatol Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.2147\/ccid.S485421","article-title":"Sustained Repigmentation in vitiligo and leukodermas using melanocyte-keratinocyte transplantation: 7 years of data","volume":"17","author":"Nuntawisuttiwong","year":"2024","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"984","DOI":"10.3390\/jcm12051984","article-title":"Management of Stable Vitiligo-a Review of the surgical approach. 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