{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T01:07:26Z","timestamp":1779930446497,"version":"3.53.1"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Adult-onset Still\u2019s disease (AOSD) is a rare systemic inflammatory disorder marked by recurrent fever, rash, arthritis, and multi-organ involvement. Its occurrence with pregnancy complicates diagnosis and management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To present the diagnosis and treatment process of two pregnant patients with newly diagnosed AOSD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Cases<\/jats:title><jats:p>Two cases of AOSD were initially diagnosed during pregnancy. Case one involved a pregnant woman at 16 + 2 weeks of gestation with recurrent fevers, rash, and myalgia. She responded well to treatment with methylprednisolone and cyclosporine and subsequently had a normal vaginal delivery. Case two involved a pregnant woman at 30 + 6 weeks of gestation who presented with systemic joint pain and fever. After being diagnosed with AOSD, she underwent a cesarean section. Treatment included methylprednisolone, cyclosporine, and addition of methotrexate postpartum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adult-onset Still\u2019s disease can be triggered by pregnancy, requiring a multidisciplinary approach for optimal management and fetal outcomes.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1588300","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T05:46:37Z","timestamp":1752126397000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Adult-onset Still\u2019s disease during pregnancy: two case reports and a comprehensive literature 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