{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T21:43:43Z","timestamp":1777326223123,"version":"3.51.4"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder affecting reproductive-age women and is often associated with infertility challenges. Recent studies suggest that vitamin D levels play a significant role in reproductive outcomes, particularly in PCOS patients undergoing <jats:italic>in vitro<\/jats:italic> fertilization (IVF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review was conducted following PRISMA guidelines. Studies published between 2014 and 2024 were analyzed, focusing on the impact of pre-treatment vitamin D levels on IVF outcomes such as fertilization rates, implantation rates, clinical pregnancy, and live birth rates. Only studies on PCOS-related infertility were included, while non-PCOS infertility cases were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The review examined 59 studies, highlighting variations in outcomes based on study design and populations. Evidence generally supports the hypothesis that adequate vitamin D levels are associated with improved IVF success, though inconsistencies remain. Further research is recommended to standardize supplementation protocols and better understand vitamin D\u2019s biological mechanisms in reproductive health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The relationship between initial vitamin D levels and <jats:italic>in vitro<\/jats:italic> fertilization (IVF) outcomes in women with polycystic ovary syndrome (PCOS) suggests that vitamin D plays a crucial role in enhancing IVF success, although the findings remain somewhat inconsistent. Research generally points to a positive correlation between higher baseline vitamin D levels and improved reproductive results, including increased live birth rates, pregnancy rates, and better ovarian responses during IVF treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic review registration<\/jats:title><jats:p>CRD42024622381, <jats:ext-link>https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD42024622381<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1589193","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T05:27:20Z","timestamp":1757482040000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The relationship between initial vitamin D levels and in vitro fertilization (IVF) outcomes in PCOS patients: a systematic review"],"prefix":"10.3389","volume":"12","author":[{"given":"Leony","family":"Octavia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dwi","family":"Andhika Panjarwanto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Putri","family":"Nabila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Putri Lenggo","family":"Geany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Mohamad","family":"Javier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo Aulia","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vallexa Septina","family":"Yora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucky","family":"Sutanto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur 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