{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:23:38Z","timestamp":1791653018142,"version":"4.3.4"},"reference-count":84,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    Essential oils have emerged as popular natural alternatives to synthetic ingredients in cosmetic products, drawing attention for their therapeutic potential in treating skin conditions like acne, psoriasis, and atopic dermatitis. This systematic review analyzed 70 studies from the past decade across multiple databases to evaluate their effectiveness and safety in derma cosmetic applications. The research encompassed clinical trials,\n                    <jats:italic>in vitro<\/jats:italic>\n                    studies, and\n                    <jats:italic>in vivo<\/jats:italic>\n                    experiments examining various essential oils in different cosmetic formulations, including lavender (\n                    <jats:italic>Lavandula angustifolia<\/jats:italic>\n                    ), tea tree (\n                    <jats:italic>Melaleuca alternifolia<\/jats:italic>\n                    ), chamomile (\n                    <jats:italic>Matricaria chamomilla<\/jats:italic>\n                    ), peppermint (\n                    <jats:italic>Mentha piperita<\/jats:italic>\n                    ), hemp (\n                    <jats:italic>Cannabis sativa<\/jats:italic>\n                    ),\n                    <jats:italic>Euphorbia characias<\/jats:italic>\n                    , hierba de San Guillermo (\n                    <jats:italic>Agrimonia<\/jats:italic>\n                    <jats:italic>eupatoria<\/jats:italic>\n                    ) and eucalyptus (\n                    <jats:italic>Eucalyptus globulus<\/jats:italic>\n                    ). Key findings demonstrated that tea tree oil was particularly effective for acne treatment, while lavender and rosemary oils showed promising anti-inflammatory and anti-aging properties. Plant extracts from\n                    <jats:italic>Ocimum gratissimum<\/jats:italic>\n                    and\n                    <jats:italic>Matricaria chamomilla<\/jats:italic>\n                    also yielded positive results for skin health improvement. Various formulations such as gels, creams, and serums showed different levels of effectiveness in enhancing skin hydration, elasticity, and overall appearance. While the clinical evidence suggests significant potential for essential oils in cosmetic and dermatological applications, researchers emphasize the need for more comprehensive, longterm clinical trials to establish their efficacy and safety profiles fully.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2025.1589691","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T04:10:31Z","timestamp":1755749431000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Evaluating efficacy, safety, and innovation in skin care applications of essential oils: a systematic review"],"prefix":"10.3389","volume":"12","author":[{"given":"Camila","family":"Pezantes-Orellana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima","family":"German Berm\u00fadez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Montalvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Packer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Orellana-Manzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"666","DOI":"10.3390\/molecules26030666","article-title":"Essential oils as natural sources of fragrance compounds for cosmetics and cosmeceuticals.","volume":"26","author":"Sharmeen","year":"2021","journal-title":"Molecules"},{"key":"B2","doi-asserted-by":"publisher","first-page":"8999","DOI":"10.3390\/molecules27248999","article-title":"Applications of essential oils and plant extracts in different industries.","volume":"27","author":"Bolouri","year":"2022","journal-title":"Molecules"},{"key":"B3","doi-asserted-by":"publisher","first-page":"791","DOI":"10.2147\/CCID.S361051","article-title":"Prevalence of skin disease and its associated factors among primary schoolchildren: A cross-sectional study from a Northern Ethiopian Town.","volume":"15","author":"Mengist Dessie","year":"2022","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3390\/COSMETICS8040114","article-title":"Essential oils and their individual components in cosmetic products.","volume":"8","author":"Guzm\u00e1n","year":"2021","journal-title":"Cosmetics."},{"key":"B5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3390\/cosmetics5010011","article-title":"Essential oils and their single compounds in cosmetics\u2014A critical review.","volume":"5","author":"Sarkic","year":"2018","journal-title":"Cosmetics."},{"key":"B6","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1080\/08927014.2024.2332709","article-title":"Antimicrobial activity of essential oils against biofilms formed in dental acrylic resin: A systematic review of in vitro studies.","volume":"40","author":"Carvalho-Silva","year":"2024","journal-title":"Biofouling"},{"key":"B7","doi-asserted-by":"publisher","first-page":"253","DOI":"10.4274\/tjps.galenos.2022.78010","article-title":"Evaluation of marketed rosemary essential oils (Rosmarinus officinalis L.) in terms of European pharmacopoeia 10.0 criteria.","volume":"20","author":"Barak","year":"2023","journal-title":"Turk J Pharm Sci"},{"key":"B8","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/ajd.12465","article-title":"Tea tree oil gel for mild to moderate acne; 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