{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T14:44:56Z","timestamp":1774449896465,"version":"3.50.1"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Menarche is one of the important indicators of girls\u2019 physical, nutritional, and reproductive health. This study aims to identify the relationship between the age at menarche and the risk of myopia at the age of 15.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Girls aged 15 were recruited when they visited the hospital for physical examination required for enrollment in the high school. Eligible participants underwent anthropometric measurements and an ocular examination, and they completed a questionnaire to gather personal information, including age at menarche. Ocular indexes were compared across early, normal, and late menarche groups, and multivariate regression was performed to analyze the relationships between age at menarche and myopia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 376 participants around the age of 15, 115 girls were classified into the early menarche group, 185 into the normal menarche group, and 76 into the late menarche group. The prevalence of myopia was 95.7, 87.6, and 86.6% for the right eye (<jats:italic>p<\/jats:italic>\u202f=\u202f0.048) and 89.6, 77.8, and 68.4% (<jats:italic>p<\/jats:italic>\u202f=\u202f0.001) for the left eye in the early, middle, and late menarche groups, respectively. Age at menarche was negatively and significantly associated with myopia, particularly with moderate to severe myopia in 15-year-old girls (<jats:italic>p<\/jats:italic>\u202f=\u202f0.039 for the right eye, <jats:italic>p<\/jats:italic>\u202f=\u202f0.001 for the left eye).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Age at menarche, as a marker of the onset of puberty, was identified as an independent risk factor of myopia in teenage girls, particularly for moderate to severe myopia. This implies that accelerated physical development during puberty may contribute to the onset and progression of myopia in the context of modern lifestyles in urban China. Additional interventions should be considered for this subgroup of children.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1590463","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T05:26:10Z","timestamp":1752557170000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between age at menarche and the risk of myopia at the age of 15 in Chongqing, China: a cross-sectional study"],"prefix":"10.3389","volume":"12","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruili","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"OuYang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Ao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LiYan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoya","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiyuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1016\/S0140-6736(12)60272-4","article-title":"Myopia","volume":"379","author":"Morgan","year":"2012","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1136\/bjophthalmol-2015-307724","article-title":"Global 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cross-sectional study","volume":"11","author":"Xu","year":"2020","journal-title":"J Dev Orig Health Dis"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"7961","DOI":"10.1167\/iovs.12-10402","article-title":"The relationship between growth spurts and myopia in Singapore children","volume":"53","author":"Yip","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1007\/s12519-023-00723-9","article-title":"Secular trends and urban-rural disparities in the median age at menarche among Chinese han girls from 1985 to 2019","volume":"19","author":"Ma","year":"2023","journal-title":"World J Pediatr"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1136\/bjophthalmol-2015-307871","article-title":"Cycloplegic autorefraction versus subjective refraction: the Tehran eye study","volume":"100","author":"Hashemi","year":"2016","journal-title":"Br J 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Zhi"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1167\/iovs.01-1276","article-title":"Regulation of estrogen receptors and MMP-2 expression by estrogens in human retinal pigment epithelium","volume":"44","author":"Marin-Casta\u00f1o","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.survophthal.2005.02.005","article-title":"Sex hormone receptors in the human eye","volume":"50","author":"Gupta","year":"2005","journal-title":"Surv Ophthalmol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1471-2415-7-9","article-title":"Corneal topographic changes in premenopausal and postmenopausal women","volume":"7","author":"Aydin","year":"2007","journal-title":"BMC Ophthalmol"},{"key":"ref21","first-page":"1380","article-title":"Form-deprivation myopia induces activation of scleral matrix metalloproteinase-2 in tree shrew","volume":"37","author":"Guggenheim","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1016\/j.exer.2009.01.012","article-title":"Inhibiting the neuronal isoform of nitric oxide synthase has similar effects on the compensatory choroidal and axial responses to myopic defocus in chicks as does the non-specific inhibitor L-NAME","volume":"88","author":"Nickla","year":"2009","journal-title":"Exp Eye Res"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"e66098","DOI":"10.1371\/journal.pone.0066098","article-title":"Physical activity and lung function growth in a cohort of Chinese school children: a prospective study","volume":"8","author":"Ji","year":"2013","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.4103\/IJO.IJO_387_23","article-title":"Prevention and management of childhood progressive myopia: national consensus 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