{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:17:04Z","timestamp":1758759424799,"version":"3.44.0"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Heterotopic occurrence of neuroglial tissue is an exceedingly rare phenomenon with unclear pathogenesis, often presenting as lesions outside the central nervous system (CNS). We report a unique case of heterotopic neuroglial tissue identified in the thoracic cavity of a fetus aborted at 14\u202fweeks due to a suspected Dandy\u2013Walker malformation. The fetus exhibited neuroglial tissue growth subpleurally, alongside a suspected Dandy\u2013Walker malformation and ventricular septal defect. While theories such as vascular embolisation, aspiration, and aberrant migration attempt to explain such occurrences, the exact etiology remains elusive. Our case suggests a potential association between triploidy and neuroglial heterotopia, supporting the aberrant migration and differentiation theory.<\/jats:p>","DOI":"10.3389\/fmed.2025.1598144","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T15:26:34Z","timestamp":1758727594000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["When neuroglial tissue wanders: a unique case report of subpleural heterotopia in a triploid foetus and review of the literature"],"prefix":"10.3389","volume":"12","author":[{"given":"Viktor","family":"Proch\u00e1zka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Skopelidou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricie","family":"Delongov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Hurn\u00edk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"\u0160pa\u010dek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Matura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Pavl\u00ed\u010dek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"G\u0159ego\u0159ov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Vaculov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jozef","family":"\u0160karda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/BF00589799","article-title":"Central nervous system heterotopia in the lung of a fetus with cranial malformation","volume":"391","author":"Campo","year":"1981","journal-title":"Virchows Arch A Pathol Anat Histol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"677","DOI":"10.24953\/turkjped.2020.04.021","article-title":"Two-year old girl with glial choristoma presented in a thyroglossal duct cyst","volume":"62","author":"\u015eal","year":"2020","journal-title":"Turk J Pediatr"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1002\/ppul.10292","article-title":"Pulmonary glial heterotopia in a monoamniotic twin","volume":"36","author":"Morgan","year":"2003","journal-title":"Pediatr Pulmonol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.annpat.2018.08.006","article-title":"Pulmonary glial heterotopia: unique lesion in an infant with anencephalic twin","volume":"39","author":"Tournier","year":"2019","journal-title":"Ann Pathol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1016\/j.jpedsurg.2009.07.033","article-title":"Bilateral cystic pulmonary glial heterotopia and palatinal teratoma causing respiratory distress in an infant","volume":"44","author":"Dettmer","year":"2009","journal-title":"J Pediatr Surg"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40748-021-00136-4","article-title":"CNS malformations in the newborn","volume":"8","author":"Bara\u00f1ano","year":"2022","journal-title":"Matern Health Neonatol Perinatol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1093\/ajcp\/aqv012","article-title":"Triploidy: variation of phenotype","volume":"145","author":"Toufaily","year":"2016","journal-title":"Am J Clin Pathol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1055\/s-0040-1716828","article-title":"Triploidy in a live-born extremely low birth weight twin: clinical aspects","volume":"11","author":"Vakrilova","year":"2022","journal-title":"J Pediatr Genet"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1097\/MPH.0b013e318215cef0","article-title":"Pulmonary glial heterotopia in a child diagnosed with Fanconi anemia and epilepsy","volume":"33","author":"Alonso","year":"2011","journal-title":"J Pediatr Hematol Oncol"},{"key":"ref10","first-page":"217","article-title":"Embolism of brain tissue to the lung in a neonate. 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