{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T17:46:29Z","timestamp":1755798389362,"version":"3.44.0"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to identify global hotspots and future trends within the research on posthepatectomy liver failure (PHLF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Bibliometric analysis through science mapping and performance analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data sources<\/jats:title><jats:p>The Web of Science Core Collection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data extraction and synthesis<\/jats:title><jats:p>The Web of Science Core Collection database was searched for literature related to PHLF from 2006 to 2024. The authors, publishing institutions, countries, cited literature, journals, and keywords of the included studies were utilized for bibliometric analysis using CiteSpace and VOSviewer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis included 986 publications authored by 296 researchers from 60 countries and 246 institutions across 292 journals. The most prolific authors were Aldrighetti Luca, Cescon Matteo and Sparrelid Ernesto. The institutions with the most publications were Naval Medical University, Ruprecht Karls University Heidelberg, and the University of Amsterdam. The countries with the largest number of publications were China, Japan, and the United States. The most commonly cited literature was \u201cposthepatectomy liver failure: a definition and grading\u201d by the International Study Group of Liver Surgery (ISGLS). Annals of Surgery ranked first in the number of co-citations among journals. Currently, the research hotspots of PHLF focus primarily on novel surgical procedures such as liver venous deprivation, associating liver partition and portal vein ligation for staged hepatectomy, and the prediction of PHLF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study elucidates the global research status of PHLF and clarifies the relevant research hotspots and trends, providing clinicians and researchers with a better understanding of the state of the art and directions for future research.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1598579","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T05:19:45Z","timestamp":1755580785000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["An in-depth analysis of research on posthepatectomy liver failure (2006-2024): exploring trends and future directions through a bibliometric approach"],"prefix":"10.3389","volume":"12","author":[{"given":"Yachen","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangtao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengliang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajid","family":"Ameer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xilin","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhangtao","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1007\/s11605-015-2872-6","article-title":"Defining post hepatectomy liver insufficiency: where do we stand?","volume":"19","author":"Lafaro","year":"2015","journal-title":"J Gastrointest Surg."},{"key":"B2","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1097\/JS9.0000000000000305","article-title":"Laparoscopic versus open repeat hepatectomy for recurrent hepatocellular carcinoma: a systematic review and meta-analysis of propensity score-matched cohort studies.","volume":"109","author":"Xiang","year":"2023","journal-title":"Int J Surg."},{"key":"B3","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s00464-023-10561-5","article-title":"Robotic versus laparoscopic liver resection for liver malignancy: a systematic review and meta-analysis of propensity score-matched studies.","volume":"38","author":"Long","year":"2024","journal-title":"Surg Endosc."},{"key":"B4","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.ejso.2023.02.010","article-title":"Laparoscopic versus open hepatectomy for intrahepatic cholangiocarcinoma: systematic review and meta-analysis of propensity score-matched studies.","volume":"49","author":"Li","year":"2023","journal-title":"Eur J Surg Oncol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1097\/SLA.0b013e31827241d5","article-title":"Incidence and risks of liver resection: an all-inclusive French nationwide study.","volume":"256","author":"Farges","year":"2012","journal-title":"Ann Surg."},{"key":"B6","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/s1072-7515(00)00261-1","article-title":"Seven hundred forty-seven hepatectomies in the 1990s: an update to evaluate the actual risk of liver resection.","volume":"191","author":"Belghiti","year":"2000","journal-title":"J Am Coll Surg."},{"key":"B7","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s13304-017-0421-4","article-title":"Meta-analysis of laparoscopic vs open liver resection for hepatocellular carcinoma.","volume":"69","author":"Sotiropoulos","year":"2017","journal-title":"Updates Surg."},{"key":"B8","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1016\/j.hpb.2020.03.013","article-title":"Systematic review of MARS treatment in post-hepatectomy liver failure.","volume":"22","author":"Sparrelid","year":"2020","journal-title":"HPB."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1080\/00365521.2018.1501604","article-title":"The impact of post-hepatectomy liver failure on mortality: a population-based study.","volume":"53","author":"Gilg","year":"2018","journal-title":"Scand J Gastroenterol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s00423-016-1512-2","article-title":"Mortality-related risk factors and long-term survival after 4460 liver resections in Sweden-a population-based study.","volume":"402","author":"Gilg","year":"2017","journal-title":"Langenbecks Arch Surg."},{"key":"B11","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1159\/000486906","article-title":"Postoperative liver failure criteria for predicting mortality after major hepatectomy with extrahepatic bile duct resection.","volume":"36","author":"Kawamura","year":"2019","journal-title":"Dig Surg."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.1007\/s11605-023-05834-2","article-title":"Postoperative liver failure: definitions, risk factors, prediction models and prevention strategies.","volume":"27","author":"Merath","year":"2023","journal-title":"J Gastrointest Surg."},{"key":"B13","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.hbpd.2023.03.001","article-title":"Post-hepatectomy liver failure: a timeline centered review.","volume":"22","author":"Bekheit","year":"2023","journal-title":"Hepatobiliary Pancreat Dis Int."},{"key":"B14","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.clinimag.2018.07.019","article-title":"The role of imaging in prediction of post-hepatectomy liver failure.","volume":"52","author":"Shen","year":"2018","journal-title":"Clin Imaging."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1007\/s00330-021-08297-8","article-title":"Predictive value of gadoxetic acid-enhanced MRI for posthepatectomy liver failure: a systematic review.","volume":"32","author":"Wang","year":"2022","journal-title":"Eur Radiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s12029-014-9646-3","article-title":"Post hepatectomy liver failure: concept of management.","volume":"45","author":"Yadav","year":"2014","journal-title":"J Gastrointest Cancer."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.1016\/j.ejso.2021.03.256","article-title":"Somatostatin perfusion and modulation of portal inflow after major liver resection: response to Post hepatectomy liver failure (PHLF)-recent advances in prevention and clinical management&quot.","volume":"47","author":"Rhaiem","year":"2021","journal-title":"Eur J Surg Oncol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"171","DOI":"10.14701\/ahbps.2021.25.2.171","article-title":"Role of liver support systems in the management of post hepatectomy liver failure: a systematic review of the literature.","volume":"25","author":"Pufal","year":"2021","journal-title":"Ann Hepatobiliary Pancreat Surg."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.4103\/1673-5374.255995","article-title":"Knowledge domain and emerging trends in Alzheimer\u2019s disease: a scientometric review based on CiteSpace analysis.","volume":"14","author":"Liu","year":"2019","journal-title":"Neural Regen Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s11192-009-0146-3","article-title":"Software survey: vosviewer, a computer program for bibliometric mapping.","volume":"84","author":"van Eck","year":"2010","journal-title":"Scientometrics."},{"key":"B21","doi-asserted-by":"publisher","first-page":"54","DOI":"10.4103\/0301-4738.151471","article-title":"Bibliometric trends in ophthalmology 1997-2009.","volume":"63","author":"Mansour","year":"2015","journal-title":"Indian J Ophthalmol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s40037-021-00695-4","article-title":"Bibliometrics: methods for studying academic publishing.","volume":"11","author":"Ninkov","year":"2022","journal-title":"Perspect Med Educ."},{"key":"B23","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s10495-023-01910-9","article-title":"A bibliometric and knowledge-map analysis of anoikis from 2003 to 2022.","volume":"29","author":"Hou","year":"2024","journal-title":"Apoptosis."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2788","DOI":"10.1097\/JS9.0000000000001202","article-title":"Global research status and frontiers on autophagy in hepatocellular carcinoma: a comprehensive bibliometric and visualized analysis.","volume":"110","author":"He","year":"2024","journal-title":"Int J Surg."},{"key":"B25","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.surg.2010.10.001","article-title":"Posthepatectomy liver failure: a definition and grading by the international study group of liver (ISGLS).","volume":"149","author":"Rahbari","year":"2011","journal-title":"Surgery."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.1097\/SLA.0000000000003496","article-title":"Intraoperative increase of portal venous pressure is an immediate predictor of posthepatectomy liver failure after major hepatectomy: a prospective study.","volume":"274","author":"Bogner","year":"2021","journal-title":"Ann Surg."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1093\/bjs\/znad233","article-title":"E-AHPBA-ESSO-ESSR Innsbruck consensus guidelines for preoperative liver function assessment before hepatectomy.","volume":"110","author":"Primavesi","year":"2023","journal-title":"Br J Surg."},{"key":"B28","doi-asserted-by":"publisher","first-page":"3640","DOI":"10.1245\/s10434-011-1829-6","article-title":"The predictive value of postoperative clinical risk scores for outcome after hepatic resection: a validation analysis in 807 patients.","volume":"18","author":"Rahbari","year":"2011","journal-title":"Ann Surg Oncol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.ijid.2022.06.017","article-title":"Trends in the disease burden of HBV and HCV infection in China from 1990-2019.","volume":"122","author":"Yue","year":"2022","journal-title":"Int J Infect Dis."},{"key":"B30","doi-asserted-by":"publisher","first-page":"67","DOI":"10.2222\/jsv.62.67","article-title":"[Present state and the future direction of HBV vaccine].","volume":"62","author":"Mizokami","year":"2012","journal-title":"Uirusu."},{"key":"B31","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/cac2.12393","article-title":"Cancer situation in China: what does the China cancer map indicate from the first national death survey to the latest cancer registration?","volume":"43","author":"Feng","year":"2023","journal-title":"Cancer Commun."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.14218\/JCTH.2023.00320","article-title":"Guidelines for the prevention and treatment of chronic Hepatitis B (version 2022).","volume":"11","author":"You","year":"2023","journal-title":"J Clin Transl Hepatol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1001\/jama.2019.2276","article-title":"Prevalence of alcoholic fatty liver disease among adults in the United States, 2001-2016.","volume":"321","author":"Wong","year":"2019","journal-title":"JAMA."},{"key":"B34","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.cld.2012.08.001","article-title":"Prevalence and natural history of alcoholic liver disease.","volume":"16","author":"Schwartz","year":"2012","journal-title":"Clin Liver Dis."},{"key":"B35","doi-asserted-by":"publisher","first-page":"269","DOI":"10.21037\/hbsn-23-96","article-title":"Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS)-a fine balance.","volume":"12","author":"Yeung","year":"2023","journal-title":"Hepatobiliary Surg Nutr."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1334661","DOI":"10.3389\/fmed.2023.1334661","article-title":"A systematic review and meta-analysis of liver venous deprivation versus portal vein embolization before hepatectomy: future liver volume, postoperative outcomes, and oncological safety.","volume":"10","author":"Chaouch","year":"2023","journal-title":"Front Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"732","DOI":"10.21037\/hbsn-22-357","article-title":"ALPPS and the endless pursuit of hepatic resectability.","volume":"11","author":"Byrne","year":"2022","journal-title":"Hepatobiliary Surg Nutr."},{"key":"B38","doi-asserted-by":"publisher","first-page":"350","DOI":"10.21037\/hbsn-20-394","article-title":"Optimization of the future remnant liver: review of the current strategies in Europe.","volume":"10","author":"Memeo","year":"2021","journal-title":"Hepatobiliary Surg Nutr."},{"key":"B39","doi-asserted-by":"publisher","first-page":"136","DOI":"10.21037\/hbsn.2019.09.10","article-title":"Preparing for liver surgery with Alphabet Soup: pve, ALPPS, TAE-PVE, LVD and RL.","volume":"9","author":"Kim","year":"2020","journal-title":"Hepatobiliary Surg Nutr."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.3390\/medicina59061099","article-title":"Predicting post-hepatectomy liver failure in HCC patients: a review of liver function assessment based on laboratory tests scores.","volume":"59","author":"Morandi","year":"2023","journal-title":"Medicina."},{"key":"B41","doi-asserted-by":"publisher","first-page":"e2877","DOI":"10.1097\/MD.0000000000002877","article-title":"Child-pugh versus MELD score for the assessment of prognosis in liver cirrhosis: a systematic review and meta-analysis of observational studies.","volume":"95","author":"Peng","year":"2016","journal-title":"Medicine."},{"key":"B42","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1200\/JCO.2014.57.9151","article-title":"Assessment of liver function in patients with hepatocellular carcinoma: a new evidence-based approach-the ALBI grade.","volume":"33","author":"Johnson","year":"2015","journal-title":"J Clin Oncol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2567","DOI":"10.1016\/j.cgh.2021.12.034.","article-title":"Low accuracy of FIB-4 and NAFLD fibrosis scores for screening for liver fibrosis in the population.","volume":"20","author":"Graupera","year":"2022","journal-title":"Clin Gastroenterol Hepatol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"109462","DOI":"10.1016\/j.ejso.2024.109462","article-title":"Preoperative prediction of post hepatectomy liver failure after surgery for hepatocellular carcinoma on CT-scan by machine learning and radiomics analyses.","volume":"51","author":"Famularo","year":"2025","journal-title":"Eur J Surg Oncol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"3197","DOI":"10.3390\/cancers15123197","article-title":"Unsupervised machine learning of mri radiomics features identifies two distinct subgroups with different liver function reserve and risks of post-hepatectomy liver failure in patients with hepatocellular carcinoma.","volume":"15","author":"Wang","year":"2023","journal-title":"Cancers."},{"key":"B46","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1159\/000513412","article-title":"Evolutions in the management of hepatocellular carcinoma over last 4 decades: an analysis from the 100 most influential articles in the field.","volume":"10","author":"Xu","year":"2021","journal-title":"Liver Cancer."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1436315","DOI":"10.3389\/fimmu.2024.1436315","article-title":"Research hotspots and trends in immunotherapy for cholangiocarcinoma: a bibliometric analysis (2014-2023).","volume":"15","author":"Qu","year":"2024","journal-title":"Front Immunol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"986867","DOI":"10.3389\/fonc.2022.986867","article-title":"Machine learning prediction model for post- hepatectomy liver failure in hepatocellular carcinoma: a multicenter study.","volume":"12","author":"Wang","year":"2022","journal-title":"Front Oncol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.2147\/JHC.S451025","article-title":"Utility of machine learning in the prediction of post-hepatectomy liver failure in liver cancer.","volume":"11","author":"Tashiro","year":"2024","journal-title":"J Hepatocell Carcinoma."},{"key":"B50","doi-asserted-by":"publisher","first-page":"7047","DOI":"10.1097\/JS9.0000000000001764","article-title":"Online interpretable dynamic prediction models for clinically significant posthepatectomy liver failure based on machine learning algorithms: a retrospective cohort study.","volume":"110","author":"Jin","year":"2024","journal-title":"Int J Surg."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1598579\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T05:19:45Z","timestamp":1755580785000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1598579\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,19]]},"references-count":50,"alternative-id":["10.3389\/fmed.2025.1598579"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1598579","relation":{},"ISSN":["2296-858X"],"issn-type":[{"type":"electronic","value":"2296-858X"}],"subject":[],"published":{"date-parts":[[2025,8,19]]},"article-number":"1598579"}}