{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:32:57Z","timestamp":1754145177783,"version":"3.41.2"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate the correlation between decreased partial pressure of arterial carbon dioxide (PaCO<jats:sub>2<\/jats:sub>) and thrombus location, as well as its association with 90-day prognosis in patients with acute pulmonary embolism (PE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective analysis was conducted on the risk factors, clinical characteristics, and diagnostic findings of PE patients presenting with decreased PaCO<jats:sub>2<\/jats:sub> at our hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate logistic regression analysis revealed that decreased PaCO<jats:sub>2<\/jats:sub> in PE was significantly associated with thrombosis in the right pulmonary artery, thrombosis in the left lower lobe pulmonary arteries, and pulmonary hypertension (PH). Pearson correlation analysis showed a weak negative correlation between decreased PaCO<jats:sub>2<\/jats:sub> and PASP and PVOI. Spearman correlation analysis indicated a weak negative correlation between decreased PaCO<jats:sub>2<\/jats:sub> and computed tomography severity (CTS)-defined risk PE. Kaplan\u2013Meier survival analysis demonstrated that decreased PaCO<jats:sub>2<\/jats:sub> was not associated with 90-day mortality (\u03c7<jats:sup>2<\/jats:sup>\u202f=\u202f0.263, <jats:italic>p<\/jats:italic>\u202f=\u202f0.608).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A significant proportion of PE patients presented with decreased PaCO<jats:sub>2<\/jats:sub>, which was correlated with thrombosis in the right pulmonary artery and left lower lobe pulmonary arteries. However, decreased PaCO<jats:sub>2<\/jats:sub> was not associated with 90-day mortality in PE patients.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1601169","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T01:27:54Z","timestamp":1750123674000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation between decreased PaCO2 and thrombus site and 90d prognosis in patients with acute pulmonary embolism"],"prefix":"10.3389","volume":"12","author":[{"given":"Danrong","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1055\/s-0044-1785487","article-title":"Epidemiology, etiology, and pathophysiology of pulmonary embolism","volume":"33","author":"Glazier","year":"2024","journal-title":"Int J Angiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"58","DOI":"10.7812\/TPP\/21.019","article-title":"Variation in positivity rates of computed tomography pulmonary angiograms for the evaluation of acute pulmonary embolism among emergency department physicians","volume":"26","author":"Higashiya","year":"2022","journal-title":"Perm 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mortality after acute pulmonary embolism","volume":"68","author":"Kotsiou","year":"2019","journal-title":"Eur J Intern Med"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/2213-0802-1-8","article-title":"The effect of high concentration oxygen therapy on PaCO2 in acute and chronic respiratory disorders","volume":"1","author":"Pilcher","year":"2013","journal-title":"Transl Respir Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"213","DOI":"10.2214\/AJR.04.1320","article-title":"Acute pulmonary embolism: correlation of CT pulmonary artery obstruction index with blood gas values","volume":"186","author":"Metafratzi","year":"2006","journal-title":"AJR Am J Roentgenol"}],"container-title":["Frontiers in 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