{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T18:06:02Z","timestamp":1767204362956,"version":"build-2238731810"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    This case report describes a rare instance of pediatric meningitis caused by\n                    <jats:italic>Bacteroides uniformis (B. uniformis)<\/jats:italic>\n                    following rotavirus gastroenteritis in a 1-year-4-month-old boy, diagnosed using metagenomics next-generation sequencing (mNGS).\n                    <jats:italic>Bacterial<\/jats:italic>\n                    meningitis (BM) is a life-threatening disease in children, particularly those under 5\u202fyears old, and early identification of the pathogen is crucial for reducing mortality and improving prognosis.\n                    <jats:italic>B. uniformis<\/jats:italic>\n                    , a Gram-negative, non-spore-forming, obligate anaerobic bacillus and common gut commensal, is rarely implicated in human infections, particularly pediatric meningitis. The child presented with vomiting, diarrhea, convulsions, and syncope, and was initially treated for meningitis and rotavirus gastroenteritis. Despite negative bacterial cultures, mNGS identified\n                    <jats:italic>B. uniformis<\/jats:italic>\n                    in the cerebrospinal fluid (CSF). Treatment was switched from ceftriaxone to meropenem (0.45\u202fg, IV every 8\u202fh) based on its good blood\u2013brain barrier penetration and likely susceptibility of\n                    <jats:italic>B. uniformis<\/jats:italic>\n                    . The child\u2019s condition improved significantly, with follow-up lumbar puncture showing normal CSF parameters and no detectable pathogens. The case suggests that rare anaerobic meningitis may occur against the backdrop of rotavirus gastroenteritis and underscores the importance of using mNGS for accurate pathogen detection in bacterial meningitis, as well as the need for early initiation of appropriate antimicrobial therapy.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2025.1601953","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T05:24:28Z","timestamp":1757395468000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Rotavirus gastroenteritis complicating meningitis caused by Bacteroides uniformis detected using mNGS: a case report and literature review"],"prefix":"10.3389","volume":"12","author":[{"given":"Ze-zheng","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-mei","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu-wen","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sa","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1186\/s12879-025-10928-0","article-title":"Epidemiological characteristics and disease burden of bacterial meningitis in hospitalized children in China: a 6-year nationwide retrospective study","volume":"25","author":"Liu","year":"2025","journal-title":"BMC Infect 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