{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T06:10:14Z","timestamp":1756447814451,"version":"3.44.0"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Eosinophilic gastroenteritis (EGE) is a rare chronic inflammatory disorder characterized by eosinophilic infiltration of the gastrointestinal tract. We report the case of a 42-year-old previously healthy man who presented with gradually worsening abdominal pain and bloating for approximately 1\u202fmonth. Initial laboratory tests showed elevated eosinophil counts, increased immunoglobulin E levels, and raised C-reactive protein. Enhanced CT revealed diffuse edema of the gastric wall, thickening of the gastric and duodenal walls, enlargement of the abdominal lymph nodes, and thickening of the peritoneum, which was suspected to be caused by malignant tumors. However, gastroscopic pathological examination and multiple ascites examinations showed no obvious malignant cells. To investigate the underlying cause, the combined <jats:sup>18<\/jats:sup>F-AlF-NOTA-FAPI-04 (<jats:sup>18<\/jats:sup>F-FAPI) positron emission tomography\/computed tomography (PET\/CT) and <jats:sup>18<\/jats:sup>F-Fluorodeoxyglucose (<jats:sup>18<\/jats:sup>F-FDG) PET\/CT were performed. The pattern of increased radionuclide uptake in these mentioned lesions differs from that of malignant neoplasms. Then, EGE was confirmed by diagnostic peritoneal biopsy. This case highlights that PET\/CT imaging combined with <jats:sup>18<\/jats:sup>F-FAPI and <jats:sup>18<\/jats:sup>F-FDG demonstrates potential utility in diagnosing EGE, particularly in distinguishing inflammatory processes from malignancies.<\/jats:p>","DOI":"10.3389\/fmed.2025.1602306","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T05:45:38Z","timestamp":1756446338000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined 18F-AlF-NOTA-FAPI-04 and 18F-Fluorodeoxyglucose PET\/CT in patients with eosinophilic gastroenteritis: a case report and literature review"],"prefix":"10.3389","volume":"12","author":[{"given":"Bo","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinghui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"100260","DOI":"10.1016\/j.jacig.2024.100260","article-title":"Challenging assumptions about the demographics of eosinophilic gastrointestinal diseases: a systematic review","volume":"3","author":"Chehade","year":"2024","journal-title":"J Allergy Clin Immunol Gl"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1097\/CM9.0000000000002511","article-title":"Eosinophilic gastroenteritis: pathogenesis, diagnosis, and treatment","volume":"136","author":"Li","year":"2023","journal-title":"Chin Med J"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1097\/ACI.0000000000000635","article-title":"Eosinophilic gastroenteritis: epidemiology, diagnosis, and treatment","volume":"20","author":"Kinoshita","year":"2020","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.3390\/diagnostics12061381","article-title":"Follow-up of a rare case of eosinophilic gastroenteritis associated with persistent blood eosinophilia and multiple food allergies","volume":"12","author":"Leru","year":"2022","journal-title":"Diagnostics (Basel)"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1159\/000369540","article-title":"Eosinophilic enteritis","volume":"33","author":"Pineton de Chambrun","year":"2015","journal-title":"Dig Dis"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/S0140-6736(22)01056-X","article-title":"Eosinophilic gastroenteritis with ascites: an enigmatic diagnosis","volume":"400","author":"Galere","year":"2022","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"111820","DOI":"10.1016\/j.ejrad.2024.111820","article-title":"Eosinophilic gastroenteritis: imaging spectrum on intestinal ultrasonography and CT enterography","volume":"181","author":"Ma","year":"2024","journal-title":"Eur J Radiol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1148\/rg.220004","article-title":"Eosinophilic disorders of the gastrointestinal tract and associated abdominal viscera: imaging findings and diagnosis","volume":"42","author":"Yalon","year":"2022","journal-title":"Radiographics"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1159\/000493668","article-title":"Eosinophilic gastrointestinal diseases in childhood","volume":"73","author":"Koutri","year":"2018","journal-title":"Ann Nutr Metab"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.gtc.2014.02.007","article-title":"Histopathologic features of eosinophilic esophagitis and eosinophilic gastrointestinal diseases","volume":"43","author":"Collins","year":"2014","journal-title":"Gastroenterol Clin N Am"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"43","DOI":"10.5114\/pg.2022.118634","article-title":"Eosinophilic gastroenteritis - a manifestation of an allergic disease in the gastrointestinal tract? 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