{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T16:26:00Z","timestamp":1758039960227,"version":"3.44.0"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the diagnostic prediction of cranial ultrasound hemodynamics in children with neonatal hyperbilirubinemia combined with germinal matrix-intraventricular hemorrhage (GMH-IVH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 148 hyperbilirubinemic neonates who underwent cranial ultrasound to obtain hemodynamic parameter indexes, and constructed a nomogram visual prediction model through unifactorial and multifactorial analyses to study the role of cranial ultrasound hemodynamic parameters in the diagnostic prediction of neonatal hyperbilirubinemia combined with GMH-IVH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 148 patients eligible for enrollment were included in this study, of which 40 children developed GMH-IVH, with an incidence rate of 27.03%. Multifactorial logistic stepwise regression analysis showed that mothers suffering from gestational hypertension, total bilirubin \u226515 mg\/dl, anterior cerebral artery third day to first day resistance index ratio of \u22651, and middle cerebral artery third day to first day resistance index ratio of \u22651 were the independent risk factors for the development of GMH-IVH in neonatal hyperbilirubinemic infants (<jats:italic>P<\/jats:italic> &amp;lt; 0.05); and ROC analysis showed that the area under the ROC curve (AUC) of the prediction model was 0.821 (95% CI: 0.746\u20130.897, <jats:italic>P<\/jats:italic> &amp;lt; 0.001), indicating good predictive efficacy of the model (discrimination), and the Hosmer-Lemeshow test (\u03c7<jats:sup>2<\/jats:sup> = 7.779, <jats:italic>P<\/jats:italic> = 0.255) and the calibration curve showed that the model had a good goodness-of-fit (calibration). The predictive model was visualized by plotting nomogram.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Craniocerebral ultrasound hemodynamics-related parameters combined with clinical features to construct a predictive model for early and effective prediction of the occurrence and prognosis of GMH-IVH in neonates with hyperbilirubinemia.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1606892","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T05:25:31Z","timestamp":1757568331000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic prediction of neonatal hyperbilirubinemia combined with germinal matrix-intraventricular hemorrhage based on cranial ultrasound hemodynamics: a retrospective case-control study"],"prefix":"10.3389","volume":"12","author":[{"given":"Zhaolan","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daoming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiantao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"486","DOI":"10.3174\/ajnr.A7434","article-title":"Comparison of papile versus laterality-based Al-Abdi system to predict neurodevelopmental impairment in extreme preterm infants after 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infants with intracranial hemorrhage during the first four days of life and analysis of perinatal factors.","volume":"4","author":"Li","year":"2004","journal-title":"Pediatr Emerg Med."},{"key":"B12","first-page":"340","article-title":"Early transcranial ultrasound Doppler monitoring of cerebral hemodynamics predicts intraventricular hemorrhage and neurodevelopmental prognosis in preterm infants.","volume":"3","author":"Liu","year":"2006","journal-title":"Fudan J Med Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/j.1469-8749.2008.03256.x","article-title":"Infection in pregnancy and cerebral palsy.","volume":"51","author":"Nelson","year":"2009","journal-title":"Dev Med Child Neurol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"25903","DOI":"10.1038\/srep25903","article-title":"Reduced cerebral blood flow and oxygen metabolism in extremely preterm neonates with low-grade germinal matrix- intraventricular 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