{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:10:18Z","timestamp":1772755818966,"version":"3.50.1"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Bladder endometriosis (BE) is an uncommon form of deep infiltrating endometriosis (DIE). This report aims to present two cases of BE with markedly contrasting clinical histories and presentations to highlight diagnostic challenges and discuss management strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We describe the clinical presentation, diagnostic workup including pelvic magnetic resonance imaging (MRI), surgical management (laparoscopic partial cystectomy), histopathological findings, and short-term follow-up of two young women diagnosed with BE. Relevant literature is reviewed to contextualize the findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both patients were accurately diagnosed preoperatively via MRI and underwent successful laparoscopic partial cystectomy, with histopathology confirming BE. Postoperative management involved a sequential protocol of gonadotropin-releasing hormone agonists (GnRH-a) followed by dienogest, which resulted in favorable short-term results, with no recurrence noted during follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Diagnosing BE is often straightforward when typical clinical and imaging findings align. However, diagnostic delays are common due to the condition\u2019s rarity and symptom overlap. Early diagnosis is crucial for achieving better outcomes. For women of reproductive age experiencing recurrent pelvic symptoms, even atypical ones, early pelvic imaging examinations are recommended. MRI plays a key role in diagnosing BE, guiding treatment decisions, and assisting with differential diagnosis. Enhancing awareness of BE among clinicians and radiologists is essential to expedite diagnosis and treatment.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1607689","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T05:33:27Z","timestamp":1756964007000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Can bladder endometriosis be hard to diagnose? A two-case report and literature review"],"prefix":"10.3389","volume":"12","author":[{"given":"Xingchen","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.1016\/j.cell.2021.04.041","article-title":"Endometriosis: Etiology, pathobiology, and therapeutic prospects","volume":"184","author":"Saunders","year":"2021","journal-title":"Cell"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/j.fertnstert.2006.11.090","article-title":"Bladder endometriosis: getting closer and closer to the unifying metastatic hypothesis","volume":"87","author":"Somigliana","year":"2007","journal-title":"Fertil Steril"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1093\/humupd\/dmy027","article-title":"Ureteral endometriosis: a systematic review of epidemiology, pathogenesis, diagnosis, treatment, risk of malignant transformation and fertility","volume":"24","author":"Barra","year":"2018","journal-title":"Hum Reprod Update"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/hropen\/hoab029","article-title":"An international terminology for endometriosis, 2021","volume":"2021","author":"Tomassetti","year":"2021","journal-title":"Hum Reprod Open"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/j.eururo.2017.01.020","article-title":"Bladder endometriosis: a rare but challenging condition","volume":"71","author":"Fauconnier","year":"2017","journal-title":"Eur Urol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"468","DOI":"10.23736\/s0026-4784.17.04059-x","article-title":"Bladder endometriosis: a summary of current evidence","volume":"69","author":"Saccardi","year":"2017","journal-title":"Minerva Ginecol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"102536","DOI":"10.1016\/j.bpobgyn.2024.102536","article-title":"Bladder endometriosis: what do we know and what is left to find out? 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