{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:29:33Z","timestamp":1789172973032,"version":"build-2803163510"},"reference-count":173,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Diabetic kidney disease (DKD), a major microvascular complication of diabetes, is closely associated with functional imbalances in ion channels regulating sodium (Na<jats:sup>+<\/jats:sup>), calcium (Ca<jats:sup>2+<\/jats:sup>), potassium (K<jats:sup>+<\/jats:sup>), and chloride (Cl<jats:sup>\u2013<\/jats:sup>). This review systematically examines the roles of ion channels in glomerular filtration barrier dysfunction, tubular reabsorption, and fibrotic processes in DKD, with emphasis on the pathological relevance of sodium-glucose cotransporter 2 (SGLT2), epithelial sodium channels (ENaC), transient receptor potential (TRP) channels, chloride channels, aquaporins (AQPs), and PIEZO channels. We further evaluate the clinical efficacy and challenges of ion channel-targeted therapies, including SGLT2 inhibitors and mineralocorticoid receptor antagonists. Emerging strategies integrating ion channel omics, machine learning, engineered biomaterials, and exosome-based delivery systems are proposed to shift DKD treatment paradigms from disease progression delay to pathological reversal. Interdisciplinary collaboration is critical to achieving personalized precision medicine, offering novel perspectives for DKD diagnosis and management.<\/jats:p>","DOI":"10.3389\/fmed.2025.1607701","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T05:29:17Z","timestamp":1750915757000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Targeting ion channel networks in diabetic kidney disease: from molecular crosstalk to precision therapeutics and clinical innovation"],"prefix":"10.3389","volume":"12","author":[{"given":"Wenfeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyuan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.mcna.2023.03.004","article-title":"Diabetic kidney disease: An update.","volume":"107","author":"Gupta","year":"2023","journal-title":"Med Clin North Am."},{"key":"B2","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s12882-025-03953-3","article-title":"New insights in the treatment of DKD: Recent advances and future prospects.","volume":"26","author":"Zhao","year":"2025","journal-title":"BMC Nephrol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"3307594","DOI":"10.1155\/jdr\/3307594","article-title":"The prevalence and progression of microvascular complications and the interaction with ethnicity and socioeconomic status in people with type 2 diabetes: A systematic review and meta-analysis.","volume":"2025","author":"Alobaid","year":"2025","journal-title":"J Diabetes Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"101463","DOI":"10.1016\/j.lanwpc.2024.101463","article-title":"China National Diabetic Chronic Complications (DiaChronic) Study Group. Prevalence of chronic kidney disease among Chinese adults with diabetes: A nationwide population-based cross-sectional study.","volume":"55","author":"Jia","year":"2025","journal-title":"Lancet Reg Health West Pac."},{"key":"B5","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/dom.15765","article-title":"Chronic kidney disease in type 2 diabetes: The size of the problem, addressing residual renal risk and what we have learned from the credence trial.","volume":"26","author":"Chaudhry","year":"2024","journal-title":"Diabetes Obes Metab."},{"key":"B6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/dom.15683","article-title":"What every clinician needs to know about chronic kidney disease: Detection, classification and epidemiology.","volume":"26","author":"Selby","year":"2024","journal-title":"Diabetes Obes Metab."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e15402","DOI":"10.1111\/dme.15402","article-title":"Management of diabetes in people with advanced chronic kidney disease.","volume":"42","author":"Chowdhury","year":"2025","journal-title":"Diabet Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"10882","DOI":"10.3390\/ijms252010882","article-title":"Crosstalk of hyperglycaemia and cellular mechanisms in the pathogenesis of diabetic kidney disease.","volume":"25","author":"Efiong","year":"2024","journal-title":"Int J Mol Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.kint.2022.05.012","article-title":"Molecular mechanisms and therapeutic targets for diabetic kidney disease.","volume":"102","author":"Tuttle","year":"2022","journal-title":"Kidney Int."},{"key":"B10","doi-asserted-by":"publisher","first-page":"570","DOI":"10.3390\/ijms24010570","article-title":"What\u2019s new in the molecular mechanisms of diabetic kidney disease: Recent advances.","volume":"24","author":"Watanabe","year":"2022","journal-title":"Int J Mol Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"958790","DOI":"10.3389\/fimmu.2022.958790","article-title":"Immune responses in diabetic nephropathy: Pathogenic mechanisms and therapeutic target.","volume":"13","author":"Chen","year":"2022","journal-title":"Front Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1111\/1753-0407.13304","article-title":"Glomerular cell cross talk in diabetic kidney diseases.","volume":"14","author":"Dong","year":"2022","journal-title":"J Diabetes."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1526090","DOI":"10.3389\/fmed.2025.1526090","article-title":"Advances in kidney disease: Pathogenesis and therapeutic targets.","volume":"12","author":"Boima","year":"2025","journal-title":"Front Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"387","DOI":"10.3390\/cells14050387","article-title":"Insights into the Roles of GLP-1, DPP-4, and SGLT2 at the crossroads of cardiovascular, renal, and metabolic pathophysiology.","volume":"6","author":"Gaggini","year":"2025","journal-title":"Cells."},{"key":"B15","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1146\/annurev-physiol-022724-105050","article-title":"Epithelial Na+ channels, immune cells, and salt.","volume":"87","author":"Kirabo","year":"2025","journal-title":"Annu Rev Physiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"17563","DOI":"10.3390\/ijms242417563","article-title":"Proteolytic activation of the epithelial sodium channel (ENaC): Its mechanisms and implications.","volume":"24","author":"Aufy","year":"2023","journal-title":"Int J Mol Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1178410","DOI":"10.3389\/fimmu.2023.1178410","article-title":"Role of epithelial sodium channel-related inflammation in human diseases.","volume":"14","author":"Chen","year":"2023","journal-title":"Front Immunol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"102112","DOI":"10.1016\/j.cpcardiol.2023.102112","article-title":"The multifunctional TRPC6 protein: Significance in the field of cardiovascular studies.","volume":"49","author":"Khan","year":"2024","journal-title":"Curr Probl Cardiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1019028","DOI":"10.3389\/fphys.2022.1019028","article-title":"Ion channels as a therapeutic target for renal fibrosis.","volume":"13","author":"Yan","year":"2022","journal-title":"Front Physiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"e23","DOI":"10.1097\/IMNA-D-23-00029","article-title":"Update on the pathogenesis, diagnosis, and treatment of diabetic tubulopathy.","volume":"11","author":"Liu","year":"2024","journal-title":"Integr Med Nephrol Androl."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1213473","DOI":"10.3389\/fimmu.2023.1213473","article-title":"Role and mechanisms of SGLT-2 inhibitors in the treatment of diabetic kidney disease.","volume":"14","author":"Dai","year":"2023","journal-title":"Front Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1159\/000527274","article-title":"The vascular disease of diabetic kidney disease.","volume":"13","author":"Lentini","year":"2023","journal-title":"Cardiorenal Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1038\/s41401-022-01031-0","article-title":"SGLT2 inhibitor empagliflozin promotes revascularization in diabetic mouse hindlimb ischemia by inhibiting ferroptosis.","volume":"44","author":"Han","year":"2023","journal-title":"Acta Pharmacol Sin."},{"key":"B24","doi-asserted-by":"publisher","first-page":"e032463","DOI":"10.1161\/JAHA.123.032463","article-title":"Potential mediators for treatment effects of novel diabetes medications on cardiovascular and renal outcomes: A meta-regression analysis.","volume":"13","author":"Rodriguez-Valadez","year":"2024","journal-title":"J Am Heart Assoc."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1093\/ndt\/gfae106","article-title":"The long-term effects of dapagliflozin in chronic kidney disease: A time-to-event analysis.","volume":"39","author":"McEwan","year":"2024","journal-title":"Nephrol Dial Transplant."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1093\/ndt\/gfab335","article-title":"Safety and efficacy of dapagliflozin in patients with focal segmental glomerulosclerosis: A prespecified analysis of the dapagliflozin and prevention of adverse outcomes in chronic kidney disease (DAPA-CKD) trial.","volume":"37","author":"Wheeler","year":"2022","journal-title":"Nephrol Dial Transplant."},{"key":"B27","doi-asserted-by":"publisher","first-page":"9998891","DOI":"10.1155\/2022\/9998891","article-title":"Risk factors for fracture in patients with coexisting chronic kidney disease and type 2 diabetes: An observational analysis from the CREDENCE trial.","volume":"2022","author":"Young","year":"2022","journal-title":"J Diabetes Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"116565","DOI":"10.1016\/j.ejmech.2024.116565","article-title":"Discovery of pyridazinone derivatives bearing tetrahydroimidazo[1,2-a]pyrazine scaffold as potent inhibitors of transient receptor potential canonical 5 to ameliorate hypertension-induced renal injury in rats.","volume":"275","author":"Xu","year":"2024","journal-title":"Eur J Med Chem."},{"key":"B29","doi-asserted-by":"publisher","first-page":"e23372","DOI":"10.1002\/jbt.23372","article-title":"Clemizole hydrochloride, a potent TRPC5 calcium channel inhibitor, prevents cisplatin-induced nephrotoxicity in Spraque-Dawley rats.","volume":"37","author":"Kuma\u015f-Kulualp","year":"2023","journal-title":"J Biochem Mol Toxicol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"98","DOI":"10.5414\/CP204645","article-title":"Sodium-glucose cotransporter-2 inhibitor treatment has differential effects on the incidence of various malignancies: Evidence from a spontaneous adverse reaction database.","volume":"63","author":"Inose","year":"2025","journal-title":"Int J Clin Pharmacol Ther."},{"key":"B31","doi-asserted-by":"publisher","first-page":"20406223241239775","DOI":"10.1177\/20406223241239775","article-title":"Comparison of different medical treatments for primary hyperaldosteronism: A systematic review and network meta-analysis.","volume":"15","author":"Ho","year":"2024","journal-title":"Ther Adv Chronic Dis."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1578400","DOI":"10.3389\/fphar.2025.1578400","article-title":"mTOR-mediated nutrient sensing and oxidative stress pathways regulate autophagy: A key mechanism for traditional Chinese medicine to improve diabetic kidney disease.","volume":"16","author":"Li","year":"2025","journal-title":"Front Pharmacol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"2146512","DOI":"10.1080\/0886022X.2022.2146512","article-title":"Advances in oxidative stress in pathogenesis of diabetic kidney disease and efficacy of TCM intervention.","volume":"45","author":"Ma","year":"2023","journal-title":"Ren Fail."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1559026","DOI":"10.3389\/fphar.2025.1559026","article-title":"An update on renal tubular injury as related to glycolipid metabolism in diabetic kidney disease.","volume":"16","author":"Feng","year":"2025","journal-title":"Front Pharmacol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.ekir.2024.10.035","article-title":"The role of mitochondria in diabetic kidney disease and potential therapeutic targets.","volume":"10","author":"Takasu","year":"2024","journal-title":"Kidney Int Rep."},{"key":"B36","doi-asserted-by":"publisher","first-page":"3386","DOI":"10.1016\/j.ekir.2024.09.019","article-title":"Unraveling diabetic kidney disease: The roles of mitochondrial dysfunction and immunometabolism.","volume":"9","author":"Narongkiatikhun","year":"2024","journal-title":"Kidney Int Rep."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1142805","DOI":"10.3389\/fendo.2023.1142805","article-title":"Chinese herbal medicine and its active compounds in attenuating renal injury via regulating autophagy in diabetic kidney disease.","volume":"14","author":"Liu","year":"2023","journal-title":"Front Endocrinol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"758","DOI":"10.3390\/nu17050758","article-title":"The potential role of advanced glycation end products in the development of kidney disease.","volume":"17","author":"Ma","year":"2025","journal-title":"Nutrients."},{"key":"B39","doi-asserted-by":"publisher","first-page":"856","DOI":"10.2337\/dbi23-0032","article-title":"Glucose regulation of \u03b2-Cell KATP channels: It is time for a new model!","volume":"73","author":"Merrins","year":"2024","journal-title":"Diabetes."},{"key":"B40","doi-asserted-by":"publisher","first-page":"e76498","DOI":"10.7759\/cureus.76498","article-title":"The pathophysiology and vascular complications of diabetes in chronic kidney disease: A comprehensive review.","volume":"16","author":"Hauwanga","year":"2024","journal-title":"Cureus."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2474203","DOI":"10.1080\/0886022X.2025.2474203","article-title":"Role of macrophages in peritoneal dialysis-associated peritoneal fibrosis.","volume":"47","author":"Chu","year":"2025","journal-title":"Ren Fail."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1534823","DOI":"10.3389\/fimmu.2024.1534823","article-title":"The role of M1\/M2 macrophage polarization in the pathogenesis of obesity-related kidney disease and related pathologies.","volume":"15","author":"Dousdampanis","year":"2025","journal-title":"Front Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1232790","DOI":"10.3389\/fendo.2023.1232790","article-title":"Advances in understanding and treating diabetic kidney disease: Focus on tubulointerstitial inflammation mechanisms.","volume":"14","author":"Xu","year":"2023","journal-title":"Front Endocrinol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"F877","DOI":"10.1152\/ajprenal.00415.2023","article-title":"Mechanisms and implications of podocyte autophagy in chronic kidney disease.","volume":"326","author":"Njeim","year":"2024","journal-title":"Am J Physiol Renal Physiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1335936","DOI":"10.3389\/fimmu.2023.1335936","article-title":"Understanding the podocyte immune responses in proteinuric kidney diseases: From pathogenesis to therapy.","volume":"14","author":"Jiang","year":"2024","journal-title":"Front Immunol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"112302","DOI":"10.1016\/j.celrep.2023.112302","article-title":"DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation.","volume":"42","author":"Nakamichi","year":"2023","journal-title":"Cell Rep."},{"key":"B47","doi-asserted-by":"publisher","first-page":"e2406532","DOI":"10.1002\/advs.202406532","article-title":"LncRNA evf-2 exacerbates podocyte injury in diabetic nephropathy by inducing cell cycle re-entry and inflammation through distinct mechanisms triggered by hnRNPU.","volume":"11","author":"Zhang","year":"2024","journal-title":"Adv Sci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"102733","DOI":"10.1016\/j.ceca.2023.102733","article-title":"Calcium signaling in polycystic kidney disease- cell death and survival.","volume":"112","author":"M\u00e1rquez-Nogueras","year":"2023","journal-title":"Cell Calcium."},{"key":"B49","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/s41581-024-00835-z","article-title":"Calcium signalling and transport in the kidney.","volume":"20","author":"Staruschenko","year":"2024","journal-title":"Nat Rev Nephrol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1681\/ASN.0000000000000212","article-title":"Podocyte injury in diabetic kidney disease in mouse models involves TRPC6-mediated calpain activation impairing autophagy.","volume":"34","author":"Salemkour","year":"2023","journal-title":"J Am Soc Nephrol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"e13810","DOI":"10.1002\/jcsm.13810","article-title":"Transcriptional intermediary factor 1\u03b3-induced irisin in skeletal muscle attenuates renal fibrosis in diabetic nephropathy.","volume":"16","author":"Kim","year":"2025","journal-title":"J Cachexia Sarcopenia Muscle."},{"key":"B52","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.nefroe.2025.02.005","article-title":"Diabetic kidney disease and polymorphisms of the ELMO1 and AGTR1 genes: Systematic review.","volume":"45","author":"Mart\u00ednez-Nava","year":"2025","journal-title":"Nefrologia."},{"key":"B53","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1186\/s12933-024-02544-0","article-title":"Genetic predisposition to nephropathy and associated cardiovascular disease in people with type 1 diabetes: Role of the angiotensinI-converting enzyme (ACE), and beyond; A narrative review.","volume":"23","author":"Mohammedi","year":"2024","journal-title":"Cardiovasc Diabetol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1210\/clinem\/dgad704","article-title":"Genetic risk scores identify people at high risk of developing diabetic kidney disease: A systematic review.","volume":"109","author":"Ali","year":"2024","journal-title":"J Clin Endocrinol Metab."},{"key":"B55","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s11255-022-03319-w","article-title":"The genetic side of diabetic kidney disease: A review.","volume":"55","author":"Song","year":"2023","journal-title":"Int Urol Nephrol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"101509","DOI":"10.1016\/j.gendis.2024.101509","article-title":"The role of lncRNAs in AKI and CKD: Molecular mechanisms, biomarkers, and potential therapeutic targets.","volume":"12","author":"Zheng","year":"2024","journal-title":"Genes Dis."},{"key":"B57","doi-asserted-by":"publisher","first-page":"155783","DOI":"10.1016\/j.prp.2024.155783","article-title":"LncRNA MALAT1 as a potential diagnostic and therapeutic target in kidney diseases.","volume":"266","author":"Puri","year":"2025","journal-title":"Pathol Res Pract."},{"key":"B58","doi-asserted-by":"publisher","first-page":"116922","DOI":"10.1016\/j.biopha.2024.116922","article-title":"A systematic review of epigenetic interplay in kidney diseases: Crosstalk between long noncoding RNAs and methylation, acetylation of chromatin and histone.","volume":"176","author":"Tan","year":"2024","journal-title":"Biomed Pharmacother."},{"key":"B59","doi-asserted-by":"publisher","first-page":"e3901","DOI":"10.1002\/cbf.3901","article-title":"Long noncoding RNA: An emerging diagnostic and therapeutic target in kidney diseases.","volume":"42","author":"Ramanathan","year":"2024","journal-title":"Cell Biochem Funct."},{"key":"B60","doi-asserted-by":"publisher","first-page":"108709","DOI":"10.1016\/j.pharmthera.2024.108709","article-title":"microRNAs in kidney diseases: Regulation, therapeutics, and biomarker potential.","volume":"262","author":"Liu","year":"2024","journal-title":"Pharmacol Ther."},{"key":"B61","doi-asserted-by":"publisher","first-page":"8474","DOI":"10.3390\/ijms25158474","article-title":"Pathogenesis of sarcopenia in chronic kidney disease-the role of inflammation, metabolic dysregulation, gut dysbiosis, and microRNA.","volume":"25","author":"Bakinowska","year":"2024","journal-title":"Int J Mol Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s11033-023-09127-4","article-title":"Interaction of estradiol and renin-angiotensin system with microRNAs-21 and -29 in renal fibrosis: Focus on TGF-\u03b2\/smad signaling pathway.","volume":"51","author":"Rajabi","year":"2024","journal-title":"Mol Biol Rep."},{"key":"B63","doi-asserted-by":"publisher","first-page":"121687","DOI":"10.1016\/j.lfs.2023.121687","article-title":"RhoA\/ROCK inhibition attenuates endothelin-1-induced glomerulopathy in the rats.","volume":"323","author":"Saleh","year":"2023","journal-title":"Life Sci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"e2404151","DOI":"10.1002\/advs.202404151","article-title":"Podocyte pathogenic bone morphogenetic protein-2 pathway and immune cell behaviors in primary membranous nephropathy.","volume":"11","author":"Cai","year":"2024","journal-title":"Adv Sci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"C292","DOI":"10.1152\/ajpcell.00382.2021","article-title":"LncRNA NEAT1 accelerates renal fibrosis progression via targeting miR-31 and modulating RhoA\/ROCK signal pathway.","volume":"324","author":"Chen","year":"2023","journal-title":"Am J Physiol Cell Physiol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/s41401-023-01148-w","article-title":"Sirtuin 6 protects against podocyte injury by blocking the renin-angiotensin system by inhibiting the Wnt1\/\u03b2-catenin pathway.","volume":"45","author":"Miao","year":"2024","journal-title":"Acta Pharmacol Sin."},{"key":"B67","doi-asserted-by":"publisher","first-page":"2680","DOI":"10.1016\/j.apsb.2023.03.019","article-title":"Overexpressed SIRT6 ameliorates doxorubicin-induced cardiotoxicity and potentiates the therapeutic efficacy through metabolic remodeling.","volume":"13","author":"Peng","year":"2023","journal-title":"Acta Pharm Sin B."},{"key":"B68","doi-asserted-by":"publisher","first-page":"115661","DOI":"10.1016\/j.biopha.2023.115661","article-title":"Finerenone protects against progression of kidney and cardiovascular damage in a model of type 1 diabetes through modulation of proinflammatory and osteogenic factors.","volume":"168","author":"Sanz-G\u00f3mez","year":"2023","journal-title":"Biomed Pharmacother."},{"key":"B69","doi-asserted-by":"publisher","first-page":"12179","DOI":"10.1038\/s41598-025-91281-9","article-title":"Predicting diabetic kidney disease with serum metabolomics and gut microbiota.","volume":"15","author":"Hu","year":"2025","journal-title":"Sci Rep."},{"key":"B70","doi-asserted-by":"publisher","first-page":"100315","DOI":"10.1016\/j.crmicr.2024.100315","article-title":"Gut microbiota and bile acids: Metabolic interactions and impacts on diabetic kidney disease.","volume":"7","author":"Liu","year":"2024","journal-title":"Curr Res Microb Sci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1026040","DOI":"10.3389\/fendo.2023.1026040","article-title":"Sodium glucose co-transporter 2 (SGLT2) inhibition via dapagliflozin improves diabetic kidney disease (DKD) over time associatied with increasing effect on the gut microbiota in db\/db mice.","volume":"14","author":"Wu","year":"2023","journal-title":"Front Endocrinol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"e23","DOI":"10.1097\/IMNA-D-23-00024","article-title":"Gut microbiota-derived metabolites: A new perspective of traditional Chinese medicine against diabetic kidney disease.","volume":"11","author":"Zhao","year":"2024","journal-title":"Integr Med Nephrol Androl."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1356176","DOI":"10.3389\/fmicb.2024.1356176","article-title":"A multi-omics approach to investigate characteristics of gut microbiota and metabolites in hypertension and diabetic nephropathy SPF rat models.","volume":"15","author":"Lu","year":"2024","journal-title":"Front Microbiol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"156037","DOI":"10.1016\/j.metabol.2024.156037","article-title":"Disruption of branched-chain amino acid homeostasis promotes the progression of DKD via enhancing inflammation and fibrosis-associated epithelial-mesenchymal transition.","volume":"162","author":"Deng","year":"2025","journal-title":"Metabolism."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1441415","DOI":"10.3389\/fendo.2024.1441415","article-title":"Intestinal flora and bile acid interactions impact the progression of diabetic kidney disease.","volume":"15","author":"Xu","year":"2024","journal-title":"Front Endocrinol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"177021","DOI":"10.1016\/j.ejphar.2024.177021","article-title":"TRPV1: A novel target for the therapy of diabetes and diabetic complications.","volume":"984","author":"Shen","year":"2024","journal-title":"Eur J Pharmacol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"F249","DOI":"10.1152\/ajprenal.00130.2024","article-title":"Non-voltage-gated Ca2+ channel signaling in glomerular cells in kidney health and disease.","volume":"327","author":"Ma","year":"2024","journal-title":"Am J Physiol Renal Physiol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"240","DOI":"10.31083\/j.fbl2810240","article-title":"The physiopathologic roles of calcium signaling in podocytes.","volume":"28","author":"Tu","year":"2023","journal-title":"Front Biosci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3892\/etm.2022.11726","article-title":"Role of ion channels in the mechanism of proteinuria (Review).","volume":"25","author":"Liu","year":"2022","journal-title":"Exp Ther Med."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.3390\/biom12111710","article-title":"The Effects of TRPC6 knockout in animal models of kidney disease.","volume":"12","author":"Dryer","year":"2022","journal-title":"Biomolecules."},{"key":"B81","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1152\/physrev.00013.2022","article-title":"Ion channels and channelopathies in glomeruli.","volume":"103","author":"Staruschenko","year":"2023","journal-title":"Physiol Rev."},{"key":"B82","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/s41581-024-00908-z","article-title":"Endothelin receptor antagonists in chronic kidney disease.","volume":"21","author":"Smeijer","year":"2025","journal-title":"Nat Rev Nephrol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.3390\/neurolint16060124","article-title":"New Insights into the Role of SGLT-2 inhibitors in the prevention of dementia.","volume":"16","author":"Hung","year":"2024","journal-title":"Neurol Int."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.3390\/jcm14041241","article-title":"SGLT2 Inhibitors: The first endothelial-protector for diabetic nephropathy.","volume":"14","author":"Viggiano","year":"2025","journal-title":"J Clin Med."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1281107","DOI":"10.3389\/fendo.2023.1281107","article-title":"Narrative review investigating the nephroprotective mechanisms of sodium glucose cotransporter type 2 inhibitors in diabetic and nondiabetic patients with chronic kidney disease.","volume":"14","author":"Speedtsberg","year":"2023","journal-title":"Front Endocrinol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3390\/antiox13010016","article-title":"Anti-Inflammation and anti-oxidation: The key to unlocking the cardiovascular potential of SGLT2 inhibitors and GLP1 receptor agonists.","volume":"13","author":"Myasoedova","year":"2023","journal-title":"Antioxidants."},{"key":"B87","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3390\/medicina61020202","article-title":"Update on the efficacy and safety of sodium-glucose co-transporter 2 inhibitors in patients with chronic diseases: a systematic review and meta-analysis.","volume":"61","author":"Liang","year":"2025","journal-title":"Medicina."},{"key":"B88","doi-asserted-by":"publisher","first-page":"e225","DOI":"10.1016\/S2542-5196(24)00026-3","article-title":"Ambient heat exposure and kidney function in patients with chronic kidney disease: A post-hoc analysis of the DAPA-CKD trial.","volume":"8","author":"Zhang","year":"2024","journal-title":"Lancet Planet Health."},{"key":"B89","doi-asserted-by":"publisher","first-page":"386","DOI":"10.4093\/dmj.2025.0220","article-title":"SGLT2 Inhibitors and GLP-1 receptor agonists in diabetic kidney disease: Evolving evidence and clinical application.","volume":"49","author":"Bae","year":"2025","journal-title":"Diabetes Metab J."},{"key":"B90","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1016\/S0140-6736(23)02230-4","article-title":"Zibotentan in combination with dapagliflozin compared with dapagliflozin in patients with chronic kidney disease (ZENITH-CKD): A multicentre, randomised, active-controlled, phase 2b, clinical trial.","volume":"402","author":"Heerspink","year":"2023","journal-title":"Lancet."},{"key":"B91","doi-asserted-by":"publisher","first-page":"e003666","DOI":"10.1136\/bmjdrc-2023-003666","article-title":"Euglycemic diabetic ketoacidosis in the era of SGLT-2 inhibitors.","volume":"11","author":"Chow","year":"2023","journal-title":"BMJ Open Diabetes Res Care."},{"key":"B92","doi-asserted-by":"publisher","first-page":"e58341","DOI":"10.7759\/cureus.58341","article-title":"Sodium-glucose cotransporter 2 inhibitor-induced euglycemic diabetic ketoacidosis: The other side of the coin!","volume":"16","author":"Kamath","year":"2024","journal-title":"Cureus."},{"key":"B93","doi-asserted-by":"publisher","first-page":"e088687","DOI":"10.1136\/bmjopen-2024-088687","article-title":"Efficacy and safety of 11 sodium-glucose cotransporter-2 inhibitors at different dosages in type 2 diabetes mellitus patients inadequately controlled with metformin: A Bayesian network meta-analysis.","volume":"15","author":"Xu","year":"2025","journal-title":"BMJ Open."},{"key":"B94","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1007\/s13300-025-01696-w","article-title":"Cardiovascular outcomes in patients with complex type 2 diabetes mellitus treated with the dual sglt inhibitor sotagliflozin: A meta-analysis.","volume":"16","author":"Wang","year":"2025","journal-title":"Diabetes Ther."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1002\/ehf2.15136","article-title":"Effects of sodium-glucose co-transporter inhibitors on individual clinical endpoints and quality of life.","volume":"12","author":"Liao","year":"2025","journal-title":"ESC Heart Fail."},{"key":"B96","doi-asserted-by":"publisher","first-page":"F158","DOI":"10.1152\/ajprenal.00240.2023","article-title":"Impaired distal renal potassium handling in streptozotocin-induced diabetic mice.","volume":"327","author":"Wu","year":"2024","journal-title":"Am J Physiol Renal Physiol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"F519","DOI":"10.1152\/ajprenal.00135.2024","article-title":"The mineralocorticoid receptor in diabetic kidney disease.","volume":"327","author":"Jia","year":"2024","journal-title":"Am J Physiol Renal Physiol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S2213-8587(24)00309-7","article-title":"Finerenone and new-onset diabetes in heart failure: A prespecified analysis of the FINEARTS-HF trial.","volume":"13","author":"Butt","year":"2025","journal-title":"Lancet Diabetes Endocrinol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1002\/ejhf.2469","article-title":"Finerenone in patients with chronic kidney disease and type 2 diabetes with and without heart failure: A prespecified subgroup analysis of the FIDELIO-DKD trial.","volume":"24","author":"Filippatos","year":"2022","journal-title":"Eur J Heart Fail."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.7326\/M23-1023","article-title":"Impact of finerenone-induced albuminuria reduction on chronic kidney disease outcomes in type 2 diabetes : A mediation analysis.","volume":"176","author":"Agarwal","year":"2023","journal-title":"Ann Intern Med."},{"key":"B101","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1111\/dom.15387","article-title":"Pharmacokinetics and pharmacodynamics of finerenone in patients with chronic kidney disease and type 2 diabetes: Insights based on FIGARO-DKD and FIDELIO-DKD.","volume":"26","author":"Eissing","year":"2024","journal-title":"Diabetes Obes Metab."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1159\/000542621","article-title":"Aldosterone synthase inhibitors for cardiorenal protection: Ready for prime time?","volume":"49","author":"Mazzieri","year":"2024","journal-title":"Kidney Blood Press Res."},{"key":"B103","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3390\/cells14050337","article-title":"Finerenone alleviates over-activation of complement C5a-C5aR1 axis of macrophages by regulating G protein subunit alpha i2 to improve diabetic nephropathy.","volume":"14","author":"Li","year":"2025","journal-title":"Cells."},{"key":"B104","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s12882-025-03985-9","article-title":"Finerenone in the management of diabetes kidney disease.","volume":"26","author":"De","year":"2025","journal-title":"BMC Nephrol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"637","DOI":"10.2147\/DMSO.S503133","article-title":"Finerenone ameliorates high glucose-induced podocytes epithelial-mesenchymal transition through the regulation of kr\u00fcppel-like factor 5 in diabetic nephropathy.","volume":"18","author":"Shu","year":"2025","journal-title":"Diabetes Metab Syndr Obes."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1329380","DOI":"10.1155\/2022\/1329380","article-title":"Klotho ameliorates podocyte injury through targeting TRPC6 channel in diabetic nephropathy.","volume":"2022","author":"Yao","year":"2022","journal-title":"J Diabetes Res."},{"key":"B107","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3892\/mmr.2023.13136","article-title":"Trpc6 knockout protects against renal fibrosis by restraining the CN-NFAT2 signaling pathway in T2DM mice.","volume":"29","author":"Sun","year":"2024","journal-title":"Mol Med Rep."},{"key":"B108","doi-asserted-by":"publisher","first-page":"2281714","DOI":"10.1080\/19336950.2023.2281714","article-title":"Voltage gated sodium and calcium channels: Discovery, structure, function, and Pharmacology.","volume":"17","author":"Catterall","year":"2023","journal-title":"Channels."},{"key":"B109","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/s41401-022-00948-w","article-title":"Low-dose nifedipine rescues impaired endothelial progenitor cell-mediated angiogenesis in diabetic mice.","volume":"44","author":"Peng","year":"2023","journal-title":"Acta Pharmacol Sin."},{"key":"B110","doi-asserted-by":"publisher","first-page":"14048","DOI":"10.3390\/ijms241814048","article-title":"New insights into the nephroprotective potential of lercanidipine.","volume":"24","author":"Hajdys","year":"2023","journal-title":"Int J Mol Sci."},{"key":"B111","doi-asserted-by":"publisher","first-page":"156046","DOI":"10.1016\/j.phymed.2024.156046","article-title":"Geniposide ameliorates diabetic nephropathy in type 2 diabetic mice by targeting AGEs-RAGE-dependent inflammatory pathway.","volume":"135","author":"Zhu","year":"2024","journal-title":"Phytomedicine."},{"key":"B112","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1016\/j.cmet.2022.05.010","article-title":"Mapping the single-cell transcriptomic response of murine diabetic kidney disease to therapies.","volume":"34","author":"Wu","year":"2022","journal-title":"Cell Metab."},{"key":"B113","doi-asserted-by":"publisher","first-page":"2387428","DOI":"10.1080\/0886022X.2024.2387428","article-title":"Single-cell RNA sequencing in diabetic kidney disease: A literature review.","volume":"46","author":"Tan","year":"2024","journal-title":"Ren Fail."},{"key":"B114","doi-asserted-by":"publisher","first-page":"F479","DOI":"10.1152\/ajprenal.00365.2021","article-title":"Functional characterization of ion channels expressed in kidney organoids derived from human induced pluripotent stem cells.","volume":"323","author":"Montalbetti","year":"2022","journal-title":"Am J Physiol Renal Physiol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1038\/s41401-022-00997-1","article-title":"Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXR\u03b1 expression and activation.","volume":"44","author":"Zhang","year":"2023","journal-title":"Acta Pharmacol Sin."},{"key":"B116","doi-asserted-by":"publisher","first-page":"e174848","DOI":"10.1172\/jci.insight.174848","article-title":"The CLCA1\/TMEM16A\/Cl- current axis associates with H2S deficiency in diabetic kidney injury.","volume":"10","author":"Lee","year":"2025","journal-title":"JCI Insight."},{"key":"B117","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.3390\/ijms24021313","article-title":"Emerging perspectives on the rare tubulopathy dent disease: Is glomerular damage a direct consequence of ClC-5 dysfunction?","volume":"24","author":"Priante","year":"2023","journal-title":"Int J Mol Sci."},{"key":"B118","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/164-2023-635","article-title":"ClC-K kidney chloride channels: From structure to pathology.","volume":"283","author":"Andrini","year":"2024","journal-title":"Handb Exp Pharmacol."},{"key":"B119","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.amjms.2021.10.029","article-title":"Deciphering the role of aquaporins in metabolic diseases: A mini review.","volume":"364","author":"Dutta","year":"2022","journal-title":"Am J Med Sci."},{"key":"B120","doi-asserted-by":"publisher","first-page":"676","DOI":"10.23876\/j.krcp.22.247","article-title":"Autophagy and regulation of aquaporins in the kidneys.","volume":"42","author":"Guo","year":"2023","journal-title":"Kidney Res Clin Pract."},{"key":"B121","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1159\/000538107","article-title":"Activation of TGR5 increases urine concentration by inducing AQP2 and AQP3 expression in renal medullary collecting ducts.","volume":"10","author":"Guo","year":"2024","journal-title":"Kidney Dis."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1021\/acssensors.4c03149","article-title":"Novel dual-emissive up-conversion fluorescent probe for imaging ectopic lipid accumulation in diabetes mellitus.","volume":"10","author":"Zhang","year":"2025","journal-title":"ACS Sens."},{"key":"B123","doi-asserted-by":"publisher","first-page":"117300","DOI":"10.1016\/j.biopha.2024.117300","article-title":"Hirudin delays the progression of diabetic kidney disease by inhibiting glomerular endothelial cell migration and abnormal angiogenesis.","volume":"179","author":"Zhang","year":"2024","journal-title":"Biomed Pharmacother."},{"key":"B124","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/s41419-023-05947-1","article-title":"Single-cell transcriptomic profiles in the pathophysiology within the microenvironment of early diabetic kidney disease.","volume":"14","author":"Tsai","year":"2023","journal-title":"Cell Death Dis."},{"key":"B125","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1093\/ndt\/gfae027","article-title":"Glomerular hyperfiltration as a therapeutic target for CKD.","volume":"39","author":"Kanbay","year":"2024","journal-title":"Nephrol Dial Transplant."},{"key":"B126","doi-asserted-by":"publisher","first-page":"BST20240419","DOI":"10.1042\/BST20240419","article-title":"PIEZO channels as multimodal mechanotransducers.","volume":"53","author":"Lacroix","year":"2025","journal-title":"Biochem Soc Trans."},{"key":"B127","doi-asserted-by":"publisher","first-page":"izaf041","DOI":"10.1093\/ibd\/izaf041","article-title":"Mechanosensitive ion channel PIEZO1 as a key regulator of intestinal fibrosis in Crohn\u2019s Disease.","volume":"7","author":"Zhang","year":"2025","journal-title":"Inflamm Bowel Dis."},{"key":"B128","doi-asserted-by":"publisher","first-page":"5418","DOI":"10.7150\/thno.86103","article-title":"Piezo1 specific deletion in macrophage protects the progression of liver fibrosis in mice.","volume":"13","author":"Luo","year":"2023","journal-title":"Theranostics."},{"key":"B129","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.3390\/ijms25031718","article-title":"Mechanosensitive cation channel piezo1 is involved in renal fibrosis induction.","volume":"25","author":"Drobnik","year":"2024","journal-title":"Int J Mol Sci."},{"key":"B130","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/s41440-023-01536-z","article-title":"Roles of the mechanosensitive ion channel Piezo1 in the renal podocyte injury of experimental hypertensive nephropathy.","volume":"47","author":"Ogino","year":"2024","journal-title":"Hypertens Res."},{"key":"B131","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1111\/bph.17434","article-title":"Involvement of Piezo 1 in inhibition of shear-induced platelet activation and arterial thrombosis by ginsenoside Rb1.","volume":"182","author":"Wang","year":"2025","journal-title":"Br J Pharmacol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"118639","DOI":"10.1016\/j.jep.2024.118639","article-title":"Effects of Panax notoginseng saponins on alleviating low shear induced endothelial inflammation and thrombosis via Piezo1 signalling.","volume":"335","author":"Liu","year":"2024","journal-title":"J Ethnopharmacol."},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.0000000634","article-title":"PIEZO1-mediated calcium signaling and podocyte injury in diabetic kidney disease.","author":"Li","year":"2025","journal-title":"J Am Soc Nephrol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"2415519","DOI":"10.1080\/0886022X.2024.2415519","article-title":"Piezo1 facilitates the initiation and progression of renal fibrosis by mediating cell apoptosis and mitochondrial dysfunction.","volume":"46","author":"Zhang","year":"2024","journal-title":"Ren Fail."},{"key":"B135","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1134\/S0006297924060075","article-title":"Pore-forming VDAC proteins of the outer mitochondrial membrane: Regulation and pathophysiological role.","volume":"89","author":"Belosludtseva","year":"2024","journal-title":"Biochemistry."},{"key":"B136","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.kint.2022.02.038","article-title":"Reticulon-1A mediates diabetic kidney disease progression through endoplasmic reticulum-mitochondrial contacts in tubular epithelial cells.","volume":"102","author":"Xie","year":"2022","journal-title":"Kidney Int."},{"key":"B137","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1080\/1061186X.2024.2412142","article-title":"A comprehensive review on recent advancements in drug delivery via selenium nanoparticles.","volume":"33","author":"Waqar","year":"2025","journal-title":"J Drug Target."},{"key":"B138","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ajpath.2024.07.007","article-title":"Single-cell advances in investigating and understanding chronic kidney disease and diabetic kidney disease.","volume":"195","author":"Bhayana","year":"2025","journal-title":"Am J Pathol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"3969","DOI":"10.3390\/ijms25073969","article-title":"Molecular targets of novel therapeutics for diabetic kidney disease: A new era of nephroprotection.","volume":"25","author":"Mazzieri","year":"2024","journal-title":"Int J Mol Sci."},{"key":"B140","doi-asserted-by":"publisher","first-page":"1521554","DOI":"10.3389\/fimmu.2025.1521554","article-title":"Unveiling macrophage dynamics and efferocytosis-related targets in diabetic kidney disease: Insights from single-cell and bulk RNA-sequencing.","volume":"16","author":"Zhang","year":"2025","journal-title":"Front Immunol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"101538","DOI":"10.4239\/wjd.v16.i2.101538","article-title":"Transcriptome and single-cell profiling of the mechanism of diabetic kidney disease.","volume":"16","author":"Zhou","year":"2025","journal-title":"World J Diabetes."},{"key":"B142","doi-asserted-by":"publisher","first-page":"949","DOI":"10.2147\/JIR.S482047","article-title":"Identifying key biomarkers related to immune response in the progression of diabetic kidney disease: Mendelian randomization combined with comprehensive transcriptomics and single-cell sequencing analysis.","volume":"18","author":"Hu","year":"2025","journal-title":"J Inflamm Res."},{"key":"B143","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s12967-025-06074-5","article-title":"Single-cell atlas reveals multi-faced responses of losartan on tubular mitochondria in diabetic nephropathy.","volume":"23","author":"Zhu","year":"2025","journal-title":"J Transl Med."},{"key":"B144","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1038\/s41467-025-56257-3","article-title":"Barcoded screening identifies nanocarriers for protein delivery to kidney.","volume":"16","author":"Wang","year":"2025","journal-title":"Nat Commun."},{"key":"B145","doi-asserted-by":"publisher","first-page":"tkae044","DOI":"10.1093\/burnst\/tkae044","article-title":"Nanomedicine embraces the treatment and prevention of acute kidney injury to chronic kidney disease transition: Evidence, challenges, and opportunities.","volume":"12","author":"Li","year":"2024","journal-title":"Burns Trauma."},{"key":"B146","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.2217\/nnm-2023-0023","article-title":"Exosomal microRNAs: Potential nanotherapeutic targets for diabetic kidney disease.","volume":"18","author":"Han","year":"2023","journal-title":"Nanomedicine."},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.09.021","article-title":"DeSUMOylation of RBMX regulates exosomal sorting of cargo to promote renal tubulointerstitial fibrosis in diabetic kidney disease.","volume":"26","author":"Yang","year":"2024","journal-title":"J Adv Res"},{"key":"B148","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1093\/ndt\/gfac040","article-title":"Design, recruitment, and baseline characteristics of the EMPA-KIDNEY trial.","volume":"37","year":"2022","journal-title":"Nephrol Dial Transplant."},{"key":"B149","doi-asserted-by":"publisher","first-page":"e35","DOI":"10.59556\/japi.72.0759","article-title":"SGLT2 inhibitors and finerenone: A friendly duo in the treatment of diabetic kidney disease?","volume":"72","author":"Asirvatham","year":"2024","journal-title":"J Assoc Physicians India."},{"key":"B150","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/s41421-022-00410-5","article-title":"Structural identification of riluzole-binding site on human TRPC5.","volume":"8","author":"Yang","year":"2022","journal-title":"Cell Discov."},{"key":"B151","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3.","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature."},{"key":"B152","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/s41592-024-02204-x","article-title":"An optogenetic method for the controlled release of single molecules.","volume":"21","author":"Kashyap","year":"2024","journal-title":"Nat Methods."},{"key":"B153","doi-asserted-by":"publisher","first-page":"e2412953","DOI":"10.1002\/adma.202412953","article-title":"Highly stretchable 3D microelectrode array for noninvasive functional evaluation of cardiac spheroids and midbrain organoids.","volume":"37","author":"Kim","year":"2025","journal-title":"Adv Mater."},{"key":"B154","doi-asserted-by":"publisher","first-page":"134782","DOI":"10.1016\/j.ijbiomac.2024.134782","article-title":"Polysaccharides from Alpinia oxyphylla fruit prevent hyperuricemia by inhibiting uric acid synthesis, modulating intestinal flora and reducing renal inflammation.","volume":"278","author":"Ren","year":"2024","journal-title":"Int J Biol Macromol."},{"key":"B155","doi-asserted-by":"publisher","first-page":"1424644","DOI":"10.3389\/fmed.2024.1424644","article-title":"Integrating serum pharmacochemistry and network pharmacology to explore potential compounds and mechanisms of Alpiniae oxyphyllae fructus in the treatment of cellular senescence in diabetic kidney disease.","volume":"11","author":"Yan","year":"2024","journal-title":"Front Med."},{"key":"B156","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1038\/s41401-024-01404-7","article-title":"Poria cocos: Traditional uses, triterpenoid components and their renoprotective pharmacology.","volume":"46","author":"Guo","year":"2025","journal-title":"Acta Pharmacol Sin."},{"key":"B157","doi-asserted-by":"publisher","first-page":"1346168","DOI":"10.3389\/fphar.2024.1346168","article-title":"Effects of Bifidobacterium bifidum tetragonum tablets and Jin Gui Ren Qi Pill on intestinal flora and metabolism in patients with diabetic kidney disease.","volume":"15","author":"Zhang","year":"2024","journal-title":"Front Pharmacol."},{"key":"B158","doi-asserted-by":"publisher","first-page":"e24-00018","DOI":"10.1097\/IMNA-D-24-00018","article-title":"New insights into the use of traditional chinese medicine for treating diabetic kidney disease by regulating DNA methylation.","volume":"11","author":"Ma","year":"2024","journal-title":"Integr Med Nephrol Androl"},{"key":"B159","doi-asserted-by":"publisher","first-page":"e00004","DOI":"10.1016\/j.biopha.2019.108904","article-title":"Use of chinese herbal medicine to inhibit podocyte damage as therapeutic strategy for membranous nephropathy.","volume":"10","author":"Zhang","year":"2023","journal-title":"Integr Med Nephrol Androl."},{"key":"B160","doi-asserted-by":"publisher","first-page":"e23-00014","DOI":"10.1097\/IMNA-D-23-00014","article-title":"Diagnosis and treatment of membranous nephropathy in integrative medicine.","volume":"11","author":"Bi","year":"2024","journal-title":"Integr Med Nephrol Androl."},{"key":"B161","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/IMNA-D-22-00010","article-title":"The combination therapy of glucocorticoids, tacrolimus, and mycophenolate mofetil in primary membranous nephropathy coexisting with type 2 diabetes mellitus: A retrospective study.","volume":"10","author":"Wang","year":"2023","journal-title":"Integr Med Nephrol Androl."},{"key":"B162","doi-asserted-by":"publisher","first-page":"F76","DOI":"10.1152\/ajprenal.00296.2021","article-title":"Transient receptor potential cation channel 6 contributes to kidney injury induced by diabetes and hypertension.","volume":"322","author":"Wang","year":"2022","journal-title":"Am J Physiol Renal Physiol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.freeradbiomed.2025.04.028","article-title":"Dapagliflozin attenuates diabetes-induced podocyte lipotoxicity via ERR\u03b1-Mediated lipid metabolism.","volume":"234","author":"Hu","year":"2025","journal-title":"Free Radic Biol Med."},{"key":"B164","doi-asserted-by":"publisher","first-page":"7117","DOI":"10.1038\/s41598-025-91278-4","article-title":"Dapagliflozin inhibits ferroptosis and ameliorates renal fibrosis in diabetic C57BL\/6J mice.","volume":"15","author":"Zhang","year":"2025","journal-title":"Sci Rep."},{"key":"B165","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/s41419-025-07396-4","article-title":"REDD1 expression in podocytes facilitates renal inflammation and pyroptosis in streptozotocin-induced diabetic nephropathy.","volume":"16","author":"Sunilkumar","year":"2025","journal-title":"Cell Death Dis."},{"key":"B166","doi-asserted-by":"publisher","first-page":"C452","DOI":"10.1152\/ajpcell.00651.2024","article-title":"Gut-kidney interaction reinforces dapagliflozin-mediated alleviation in diabetic nephropathy.","volume":"328","author":"Ni","year":"2025","journal-title":"Am J Physiol Cell Physiol."},{"key":"B167","doi-asserted-by":"publisher","first-page":"115840","DOI":"10.1016\/j.biopha.2023.115840","article-title":"Central administration of Dapagliflozin alleviates a hypothalamic neuroinflammatory signature and changing tubular lipid metabolism in type 2 diabetic nephropathy by upregulating MCPIP1.","volume":"168","author":"Da","year":"2023","journal-title":"Biomed Pharmacother."},{"key":"B168","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s00018-025-05688-8","article-title":"SGLT2 inhibitor empagliflozin ameliorates tubulointerstitial fibrosis in DKD by downregulating renal tubular PKM2.","volume":"82","author":"Cai","year":"2025","journal-title":"Cell Mol Life Sci."},{"key":"B169","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s10020-025-01138-0","article-title":"Empagliflozin ameliorates renal and metabolic derangements in obese type 2 diabetic mice by blocking advanced glycation end product-receptor axis.","volume":"31","author":"Matsui","year":"2025","journal-title":"Mol Med."},{"key":"B170","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1021\/acsptsci.4c00552","article-title":"Sodium-glucose cotransporter-2 inhibitor improves renal injury by regulating the redox profile, inflammatory parameters, and pyroptosis in an experimental model of diabetic kidney disease.","volume":"8","author":"Machado-Junior","year":"2025","journal-title":"ACS Pharmacol Transl Sci."},{"key":"B171","doi-asserted-by":"publisher","first-page":"116821","DOI":"10.1016\/j.bcp.2025.116821","article-title":"Empagliflozin attenuates renal damage in diabetic nephropathy by modulating mitochondrial quality control via Prdx3-PINK1 pathway.","volume":"235","author":"Guo","year":"2025","journal-title":"Biochem Pharmacol."},{"key":"B172","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1186\/s12964-024-01914-1","article-title":"Inhibition of SGLT2 protects podocytes in diabetic kidney disease by rebalancing mitochondria-associated endoplasmic reticulum membranes.","volume":"22","author":"Li","year":"2024","journal-title":"Cell Commun Signal."},{"key":"B173","doi-asserted-by":"publisher","first-page":"102946","DOI":"10.1016\/j.redox.2023.102946","article-title":"Non-steroidal mineralocorticoid receptor antagonist finerenone ameliorates mitochondrial dysfunction via PI3K\/Akt\/eNOS signaling pathway in diabetic tubulopathy.","volume":"68","author":"Yao","year":"2023","journal-title":"Redox Biol."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1607701\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T05:29:18Z","timestamp":1750915758000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1607701\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,26]]},"references-count":173,"alternative-id":["10.3389\/fmed.2025.1607701"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1607701","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,26]]},"article-number":"1607701"}}