{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:00:16Z","timestamp":1753891216808,"version":"3.41.2"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Metastasis of rhabdomyosarcoma (RMS) from primary paranasal sinuses to the pancreas is rare. Herein, we present a rare case of diffuse pancreatic metastasis in a 44-year-old man. He was diagnosed with sinus RMS 1\u202fyear ago and the lesion disappeared after systematic treatment. The patient came to our hospital in November 2022 due to abdominal pain. Abdominal ultrasound showed diffuse enlargement of the pancreas, with enlarged lymph nodes visible around the pancreas and retroperitoneum. He then underwent positron emission tomography\/computed tomography (PET\/CT) imaging and the results showed that the pancreas had diffusely increased fluorine-18 fluorodeoxyglucose (<jats:sup>18<\/jats:sup>F-FDG) uptake, and the surrounding pancreas and retroperitoneal lymph nodes also had increased <jats:sup>18<\/jats:sup>F-FDG uptake, suggesting a possibility of malignant tumor. Ultimately, a pancreatic puncture biopsy confirmed RMS with pancreatic and abdominal lymph nodes metastasis. Our case suggests that although diffuse metastatic tumors of the pancreas are relatively rare, which should be considered as one of the differential diagnoses for diffuse pancreatic hypermetabolic lesions on PET\/CT imaging.<\/jats:p>","DOI":"10.3389\/fmed.2025.1609837","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T05:43:25Z","timestamp":1748583805000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: 18F-FDG PET\/CT revealed diffuse pancreatic metastasis in paranasal sinuses rhabdomyosarcoma after treatment improvement"],"prefix":"10.3389","volume":"12","author":[{"given":"Xianwen","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haojun","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongpeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongfeng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"155406","DOI":"10.1016\/j.prp.2024.155406","article-title":"Pathogenetic and molecular classifications of soft tissue and bone tumors: a 2024 update","volume":"260","author":"Patrichi","year":"2024","journal-title":"Pathol Res Pract"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.mayocp.2012.01.015","article-title":"Common musculoskeletal tumors of childhood and adolescence","volume":"87","author":"Arndt","year":"2012","journal-title":"Mayo Clin Proc"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00428-019-02676-9","article-title":"The current landscape of rhabdomyosarcomas: an update","volume":"476","author":"Leiner","year":"2020","journal-title":"Virchows Arch"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"CD012325","DOI":"10.1002\/14651858.CD012325.pub2","article-title":"Fluorine-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) computed tomography (CT) for the detection of bone, lung, and lymph node metastases in rhabdomyosarcoma","volume":"2021","author":"Vaarwerk","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"ref5","first-page":"50","article-title":"Metastatic tumors to the pancreas, a single center study","volume":"22","author":"Geramizadeh","year":"2019","journal-title":"Arch Iran Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1007\/s12328-023-01817-7","article-title":"Successful radiotherapy for recurrent obstructive pancreatitis secondary to pancreatic metastasis from cervical squamous-cell carcinoma","volume":"16","author":"Nakajima","year":"2023","journal-title":"Clin J Gastroenterol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"247","DOI":"10.5114\/wo.2022.120593","article-title":"Distant organ metastasis patterns in lung cancer patients with pancreatic metastasis - 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