{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:47:00Z","timestamp":1765234020246,"version":"3.44.0"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Optimal timing of final intrauterine transfusion (IUT) and delivery in fetal anemia remains controversial, balancing procedural risks against prematurity complications. Our objective is to evaluate the safety and effectiveness of extending IUT beyond 34\u202fweeks gestation in appropriately selected cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study comparing pregnancies receiving late IUT (\u226534\u202fweeks, <jats:italic>n<\/jats:italic>\u202f=\u202f21) versus early IUT (&amp;lt;34\u202fweeks, <jats:italic>n<\/jats:italic>\u202f=\u202f31) at a single tertiary center (2005\u20132024). We analyzed 200 IUT procedures in 52 pregnancies. Late IUT was offered to stable cases without hydrops or previous significant complications. Primary outcomes included procedure-related complications and prematurity-related outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Late IUT showed no increase in procedure-related complications (0% vs. 20.0%, <jats:italic>p<\/jats:italic>\u202f=\u202f0.069). Mean gestational age at delivery was higher in the late IUT group (37.2\u202f\u00b1\u202f1.06 vs. 34.1\u202f\u00b1\u202f3.6\u202fweeks, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001), with reduced emergency cesarean rates (19% vs. 45%), higher birth weights (2,960\u202f\u00b1\u202f399\u202fg vs. 2,350\u202f\u00b1\u202f620\u202fg, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001), and lower NICU admission rates (29% vs. 71%, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.05). These benefits persisted after adjusting for maternal characteristics. Subgroup analysis of hemolytic disease cases showed similar improvements with additional benefits in neonatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Extending IUT beyond 34\u202fweeks in selected cases is safe and associated with improved obstetric and neonatal outcomes, supporting reconsideration of traditional gestational age limits for IUT.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1614989","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T06:06:54Z","timestamp":1757052414000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Late vs. early intrauterine blood transfusion in fetal anemia: impact on maternal and neonatal outcomes"],"prefix":"10.3389","volume":"12","author":[{"given":"Adva","family":"Cahen Peretz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilah","family":"Tsaitlin-Mor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gideon","family":"Leibner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah 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Gynecol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1111\/1471-0528.12063","article-title":"Increased perinatal loss after intrauterine transfusion for alloimmune anaemia before 20 weeks of gestation","volume":"120","author":"Lindenburg","year":"2013","journal-title":"BJOG"},{"key":"ref8","first-page":"400","article-title":"Outcome of infants receiving in-utero transfusions for haemolytic disease","volume":"114","author":"Farrant","year":"2001","journal-title":"N Z Med J"},{"year":"2018","key":"ref9","first-page":"e49"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1038\/s41372-023-01785-3","article-title":"Alloimmune hemolytic disease of the fetus and newborn: genetics, structure, and function of the commonly involved erythrocyte antigens","volume":"43","author":"Christensen","year":"2023","journal-title":"J 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