{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:28:20Z","timestamp":1793330900020,"version":"4.5.0"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Pityriasis lichenoides et varioliformis acuta (PLEVA) is a relatively rare inflammatory skin disorder encountered in clinical practice. Stapokibart is a humanized monoclonal antibody drug targeting the interleukin receptor subunit \u03b1 (IL-4R\u03b1), and is primarily used for the treatment of atopic dermatitis. Currently, owing to the rarity of PLEVA in clinical practice, there have been no reports on the use of Stapokibart in its treatment. This article presents a case in which stapokibart was used to treat a patient with acute acneiform lichenoid pityriasis, demonstrating its clinical efficacy. Following treatment with biological agents, the patient\u2019s rash completely resolved, and their quality of life significantly improved, without any adverse reactions. This case provides a valuable reference for the clinical treatment of PLEVA.<\/jats:p>","DOI":"10.3389\/fmed.2025.1615108","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T11:26:30Z","timestamp":1756725990000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Successful treatment of pityriasis lichenoides et varioliformis acuta with stapokibart: a case report"],"prefix":"10.3389","volume":"12","author":[{"given":"Rongqiao","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zunfeng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengying","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1111\/pde.15645","article-title":"What is pityriasis lichenoides?","volume":"41","year":"2024","journal-title":"Pediatr Dermatol."},{"key":"B2","first-page":"481","article-title":"Le parapsoriasis ulc\u00e9ro-n\u00e9crotique hyperthermique. Forme suraigu\u00eb du parapsoriasis en gouttes [Hyperthermic ulcero-necrotic parapsoriasis. Subacute form of parapsoriasis guttata].","volume":"93","author":"Degos","year":"1966","journal-title":"Ann Dermatol Syphiligr."},{"key":"B3","author":"Fayven","year":"2023","journal-title":"Pityriasis Lichenoides Et Varioliformis Acuta (PLEVA)."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1111\/jdv.15813","article-title":"A systematic review of treatments for pityriasis lichenoides.","volume":"33","author":"Bellinato","year":"2019","journal-title":"J Eur Acad Dermatol Venereol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2953","DOI":"10.1007\/s12325-024-02887-w","article-title":"Pharmacokinetics, pharmacodynamics, safety, and tolerability of stapokibart in healthy volunteers and adult subjects with atopic dermatitis.","volume":"41","author":"Zhang","year":"2024","journal-title":"Adv Therapy."},{"key":"B6","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s40259-024-00668-z","article-title":"Long-term efficacy and safety of stapokibart in adults with moderate-to-severe atopic dermatitis: an open-label extension.","volume":"38","author":"Zhao","year":"2024","journal-title":"Nonrandomized Clinical Trial. BioDrugs."},{"key":"B7","doi-asserted-by":"crossref","first-page":"110721","DOI":"10.1016\/j.isci.2024.110721","article-title":"Stapokibart (CM310) targets IL-4R\u03b1 for the treatment of type 2 inflammation.","volume":"27","author":"Liu","year":"2024","journal-title":"iScience."},{"key":"B8","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1684\/ejd.2023.4483","article-title":"Successful therapy with dupilumab for pityriasis lichenoides et varioliformis acuta.","volume":"33","author":"Zheng","year":"2023","journal-title":"Eur J Dermatol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1053\/hupa.2002.125381","article-title":"Pityriasis lichenoides: a clonal T-cell lymphoproliferative disorder.","volume":"33","author":"Magro","year":"2002","journal-title":"Hum Pathol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.jaci.2014.11.001","article-title":"The 3 major types of innate and adaptive cell-mediated effector immunity.","volume":"135","author":"Annunziato","year":"2015","journal-title":"J Allergy Clin Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1111\/j.1365-2133.2004.05920.x","article-title":"Successful treatment of pityriasis lichenoides with topical tacrolimus.","volume":"150","author":"Simon","year":"2004","journal-title":"Br J Dermatol."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1615108\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T11:26:31Z","timestamp":1756725991000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1615108\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":11,"alternative-id":["10.3389\/fmed.2025.1615108"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1615108","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,1]]},"article-number":"1615108"}}