{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:17:00Z","timestamp":1789636620133,"version":"4.0.0"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to elucidate the global research dynamics of brucellosis through bibliometric visualization analysis. The findings have major implications for advancing academic progress in the field of brucellosis research, fostering interdisciplinary collaboration, and strengthening disease prevention and control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Web of Science Core Collection database was utilized as the data source for this study, and literature published between January 1, 1901, and December 31, 2024 was retrieved. CiteSpace and VOSviewer software tools were employed to conduct a visual analysis of the publication volume, countries, institutions, authors, journals, and keywords.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 12,810 articles were included in this analysis, with the first publication dating back to 1901.The annual publication volume has increased over the years. The United States had the highest volume of publications and intermediary centrality. The United States Department of Agriculture (USDA) and the journal\n                      <jats:italic>Infection and Immunity<\/jats:italic>\n                      were found to be the most influential. Professors Kim S. and Pappas G. have made the most significant contributions to the field of brucellosis. Keyword analysis indicated that the top five high-frequency keywords were \u201c\n                      <jats:italic>brucella abortus<\/jats:italic>\n                      ,\u201d \u201cinfection,\u201d \u201c\n                      <jats:italic>brucella melitensis<\/jats:italic>\n                      ,\u201d \u201cdiagnosis,\u201d and \u201ccattle.\u201d Among the five formed clusters, cluster #0 (virulence) was larger and newer, with persisting research hotspots. In the keyword burst analysis, the keyword \u201celisa\u201d exhibited the highest burst strength of 41.47. Recent emerging keywords include \u201cone health,\u201d \u201crisk factors,\u201d and \u201cseroprevalence.\u201d\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study indicates that brucellosis research is predominantly concentrated in developed countries such as the United States. Professor Pappas is a key contributor in this research area. The \u201cone health\u201d approach to brucellosis is a current research hotspot. Based on these findings, future studies focused on content, methods, and value may represent a new trend in brucellosis research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1617217","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T05:16:56Z","timestamp":1763356616000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Global research hotspots and trends in brucellosis: a bibliometric and visualization analysis based on CiteSpace and VOSviewer"],"prefix":"10.3389","volume":"12","author":[{"given":"Wen","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghai","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimeng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"531","DOI":"10.3390\/bios12070531","article-title":"Gold nanoparticles prepared with cyclodextrin applied to rapid vertical flow technology for the detection of brucellosis","volume":"12","author":"Fang","year":"2022","journal-title":"Biosensors (Basel)."},{"key":"B2","doi-asserted-by":"publisher","first-page":"151","DOI":"10.21307\/pjm-2018-029","article-title":"Brucella - virulence factors, pathogenesis and treatment","volume":"67","author":"Glowacka","year":"2018","journal-title":"Pol J Microbiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1089\/vbz.2023.0092","article-title":"Risk factors associated with human brucellosis: a systematic review and meta-analysis","volume":"24","author":"Narimisa","year":"2024","journal-title":"Vector Borne ZoonoticDis"},{"key":"B4","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1089\/vbz.2021.0015","article-title":"Congenital brucellosis: a case report","volume":"21","author":"Xu","year":"2021","journal-title":"Vector Borne Zoonotic Dis."},{"key":"B5","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s00284-025-04063-x","article-title":"Human brucellosis in the rural and urban population of Pakistan: seroprevalence, risk factors, and clinical manifestations","volume":"82","author":"Abbas","year":"2025","journal-title":"Curr Microbiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e8164","DOI":"10.1371\/journal.pntd.0008164","article-title":"Occupational exposure to Brucella spp","volume":"14","author":"Pereira","year":"2020","journal-title":"PLoS Negl Trop Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e41378","DOI":"10.7759\/cureus.41378","article-title":"Seroprevalence of brucellosis in patients having complained of joint pain: a case control","volume":"15","author":"Kumari","year":"2023","journal-title":"Cureus."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e11704","DOI":"10.1097\/MD.0000000000011704","article-title":"One-stage surgical management for lumber Brucella spondylitis with anterior debridement, autogenous graft, and instrumentation","volume":"97","author":"Yin","year":"2018","journal-title":"Medicine (Baltimore)."},{"key":"B9","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.jfo.2023.02.017","article-title":"Ophthalmological findings in brucellosis","volume":"46","author":"Karakurt","year":"2023","journal-title":"J Fr Ophtalmol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.3201\/eid2909.230052","article-title":"Global estimate of human brucellosis incidence","volume":"29","author":"Laine","year":"2023","journal-title":"Emerg Infect Dis."},{"key":"B11","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1186\/s40001-025-03068-3","article-title":"Progress in brucellosis immune regulation inflammatory mechanisms and diagnostic advances","volume":"30","author":"Lu","year":"2025","journal-title":"Eur J Med Res."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaf522","article-title":"Single-cell transcriptome profiling reveals the immune dysregulation characteristics of mice infected by Brucella abortus","author":"Zhang","year":"2025"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e260072","DOI":"10.1136\/bcr-2024-260072","article-title":"Misidentification of Brucella melitensis as Ochrobactrum species: potential pitfalls in the diagnosis of brucellosis","volume":"17","author":"Howley","year":"2024","journal-title":"BMJ Case Rep."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e13185","DOI":"10.1371\/journal.pntd.0013185","article-title":"What do we really know about brucellosis diagnosis in livestock worldwide? 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