{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:30:27Z","timestamp":1789475427835,"version":"build-2803163510"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:italic>Coxiella burnetii<\/jats:italic> is a bacterial pathogen of Q fever. <jats:italic>Coxiella burnetii<\/jats:italic> infection in the lumbar vertebra is a rare form of chronic Q fever, which poses significant obstacles in both diagnostic processes and therapeutic interventions. A 57-year-old male patient with a previous diagnosis of lumbar infection with unknown pathogen at another institution was admitted for treatment. At our institution, the patient underwent surgical interventions, including decompression through total laminectomy, lesion excision, intervertebral bone graft fusion, and fixation. Intraoperative pathological samples were analyzed using a specific multiplex quantitative polymerase chain reaction (qPCR) pathogenic microorganism detection, confirming the presence of <jats:italic>Coxiella burnetii<\/jats:italic>. Postoperatively, the patient received long-term antibiotic therapy by oral doxycycline and ciprofloxacin for a duration plan of 18 months. At the 6-month post-operative evaluation, the patient exhibited complete resolution of clinical symptoms, and imaging results revealed no evidence of infection recurrence, suggesting a clinical cure. The combination of decompression through total laminectomy, lesion excision, intervertebral bone graft fusion, and fixation alongside oral doxycycline and ciprofloxacin treatment has been demonstrated to be an effective therapeutic strategy for managing <jats:italic>Coxiella burnetii<\/jats:italic> infection in the lumbar vertebra.<\/jats:p>","DOI":"10.3389\/fmed.2025.1618670","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T05:32:15Z","timestamp":1754026335000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Coxiella burnetii infection in the lumbar vertebra: a rare case report and review of literature"],"prefix":"10.3389","volume":"12","author":[{"given":"Xingguo","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjia","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dashuai","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanpeng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songkai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1128\/cmr.00045-16","article-title":"From Q Fever to Coxiella burnetii infection: a paradigm change.","volume":"30","author":"Eldin","year":"2017","journal-title":"Clin Microbiol Rev."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1099\/00207713-47-4-1255","article-title":"Reassessment of the taxonomic position of Rickettsiella grylli.","volume":"47","author":"Roux","year":"1997","journal-title":"Int J Syst Bacteriol"},{"key":"B3","doi-asserted-by":"crossref","DOI":"10.1128\/9781555816728","author":"Versalovic","year":"2011","journal-title":"Manual of Clinical Microbiology."},{"key":"B4","doi-asserted-by":"publisher","first-page":"299","DOI":"10.5694\/j.1326-5377.1937.tb43744.x","article-title":"Experimental studies on the virus of \u201cQ\u201d fever.","volume":"2","author":"Burnet","year":"1937","journal-title":"Med J Aust."},{"key":"B5","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1093\/clinids\/5.4.790","article-title":"Fever, a new fever entity: Clinical features, diagnosis and laboratory investigation.","volume":"5","author":"Derrick","year":"1983","journal-title":"Rev Infect Dis"},{"key":"B6","doi-asserted-by":"publisher","first-page":"655715","DOI":"10.3389\/fvets.2021.655715","article-title":"The prevalence of Coxiella burnetii in hard ticks in Europe and their role in Q Fever transmission revisited-a systematic review.","volume":"8","author":"K\u00f6rner","year":"2021","journal-title":"Front Vet Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1097\/00005792-200003000-00005","article-title":"Q fever 1985-1998. 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