{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:56:02Z","timestamp":1780491362339,"version":"3.54.1"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Acute viral hepatitis (AVH) remains a global health concern, with significant variations in incidence, mortality, and DALYs across different regions, age groups, genders, and socioeconomic levels. This study explores AVH trends using data from the Global Burden of Disease (GBD) database (1990\u20132021).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed age-standardized incidence, mortality, and DALY rates across 204 countries and 27 super-regions. Trends were quantified using the estimated annual percentage change (EAPC) and decomposition analysis to assess the contributions of population growth, aging, and epidemiological shifts. Autoregressive integrated moving average (ARIMA) and age-period-cohort (APC) models were also applied, while global health inequalities were evaluated via the Slope Index of Inequality (SII) and Concentration Index (CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Incidence and mortality rates were notably higher in individuals under 20 and over 80\u202fyears, with males consistently at greater risk than females. Acute Hepatitis A predominates in low-SDI regions, whereas Acute Hepatitis B is more prevalent in high-SDI regions. Projections indicate a continued decline in AVH burden by 2031, driven by population dynamics and epidemiological changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While global AVH burden is decreasing, significant disparities persist, warranting tailored interventions to enhance resource equity in high-SDI regions and strengthen healthcare infrastructure in low-SDI areas.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1620371","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T05:27:09Z","timestamp":1757482029000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Global, regional, and national burden of acute hepatitis (1990\u20132021): a systematic analysis of the global burden of disease in 2021"],"prefix":"10.3389","volume":"12","author":[{"given":"Zhixun","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongping","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houze","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.jhep.2019.03.004","article-title":"Global liver disease burdens and research trends: analysis from a Chinese perspective","volume":"71","author":"Xiao","year":"2019","journal-title":"J Hepatol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the global burden of disease study 2019","volume":"396","year":"2020","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1007\/s12072-024-10640-2","article-title":"Global burden and trends of acute viral hepatitis among children and adolescents from 1990 to 2019: a systematic analysis of the global burden of disease study 2019","volume":"18","author":"Xiao","year":"2024","journal-title":"Hepatol Int"},{"key":"ref4","first-page":"102","article-title":"\u7518\u80c6\u9178\u5bf9\u6162\u6027\u809d\u75c5\u7684\u8bca\u65ad\u610f\u4e49","volume":"20","author":"\u5eb7","year":"2018","journal-title":"\u6e56\u5317\u4e2d\u533b\u836f\u5927\u5b66\u5b66\u62a5"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.jhep.2021.04.035","article-title":"Global burden of acute viral hepatitis and its association with socioeconomic development status, 1990-2019","volume":"75","author":"Zeng","year":"2021","journal-title":"J Hepatol"},{"key":"ref6","volume-title":"Acute hepatitis. 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